دورية أكاديمية
أعرض في EDS

Prospective study on health-related quality of life, oral mucositis and oral health on during treatment of head and neck cancer.

التفاصيل البيبلوغرافية
العنوان: Prospective study on health-related quality of life, oral mucositis and oral health on during treatment of head and neck cancer.
المؤلفون: Karlsson C; Section 4- Oral Health, Malmö University, Malmö, Sweden. charlott.karlsson@mau.se.; Department of Oral and Maxillofacial Surgery, Institute for Postgraduate Dental Education, Jönköping, Sweden. charlott.karlsson@mau.se., Bohm N; Deptartment of Oral Microbiology and Immunology, Institute of Odontology, Sahlgrenska Academy, University of Gothenburg, Göteborg, Sweden., Andersson JS; Deptartment of Periodontology, Institute of Odontology, Sahlgrenska Academy, University of Gothenburg, Göteborg, Sweden., Finizia C; Department of Otorhinolaryngology, Head and Neck Surgery, Institute of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg, Göteborg, Sweden.; Department of Otorhinolaryngology, Head and Neck Surgery, Region Västra Götaland, Sahlgrenska University Hospital, Gothenburg, Sweden., Almståhl A; Section 4- Oral Health, Malmö University, Malmö, Sweden.; Deptartment of Oral Microbiology and Immunology, Institute of Odontology, Sahlgrenska Academy, University of Gothenburg, Göteborg, Sweden.
المصدر: BMC oral health [BMC Oral Health] 2024 Jun 15; Vol. 24 (1), pp. 697. Date of Electronic Publication: 2024 Jun 15.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: BioMed Central Country of Publication: England NLM ID: 101088684 Publication Model: Electronic Cited Medium: Internet ISSN: 1472-6831 (Electronic) Linking ISSN: 14726831 NLM ISO Abbreviation: BMC Oral Health Subsets: MEDLINE
أسماء مطبوعة: Original Publication: London : BioMed Central, [2001-
مواضيع طبية MeSH: Quality of Life* , Stomatitis*/etiology , Stomatitis*/psychology , Head and Neck Neoplasms*/psychology , Head and Neck Neoplasms*/complications , Head and Neck Neoplasms*/therapy , Oral Health*, Humans ; Prospective Studies ; Male ; Female ; Middle Aged ; Aged ; Adult ; Xerostomia/psychology ; Xerostomia/etiology ; Follow-Up Studies ; Saliva/metabolism ; Saliva/chemistry ; Salivation/drug effects ; Surveys and Questionnaires
مستخلص: Background: Few studies have examined health related Quality of Life (HR-QoL) during the treatment of head and neck cancer (HNC) with even fewer focusing on the impact of oral mucositis (OM) on HR-QoL. Studies performed during treatment of HNC makes it possible to follow fluctuations in HR-QoL, OM and other treatment related side effects. The aim was to prospectively analyze HR-QoL, changes in clinical variables and the impact of OM on HR-QoL during HNC treatment.
Materials and Methods: Patients were recruited before commencing curative cancer treatment and were given professional oral care weekly during oncologic treatment. HR-QoL was reported before, during (week 2, 4 and 6) and three months after treatment using the EORTC Quality of Life questionnaires C30 and H&N35 and the stimulated whole salivary secretion rate was determined at the same time-points. OM (erythema and ulceration) was registered using the Oral Mucositis Assessment Scale (OMAS), at baseline, weekly during treatment and post treatment. Differences in HR-QoL between different timepoints were analyzed. To analyze the impact of OM on HR-QoL the patients were categorized into two groups: no/mild OM (OMAS ulceration score 0-1) or severe OM (OMAS ulceration score ≥ 2) and HR-QoL was compared between the two OM groups at three timepoints during treatment.
Results: Fifty-seven patients (43 men, 14 women), with a mean age of 58 years were included. Patients reported progressively impaired HR-QoL, with peak issues noted at weeks 4 and 6, particularly in social eating, senses, appetite loss, sticky saliva, and decreasing salivary secretion rates were determined. Patients with severe OM reported worse HR-QoL compared to those with no/mild OM. Persistent problems 3 months post treatment were appetite loss, dry mouth, senses (smell and taste) and problems with social eating.
Conclusion: Patients experienced exacerbated symptoms and problems weeks 4 and 6 of oncological treatment, especially among those with severe OM, stressing the importance of clinically monitoring the patients to reduce and alleviate their symptoms. Persistent problems three months post treatment are likely associated with the reduced salivary secretion rate indicating that patients should be monitored also after completed oncological treatment.
(© 2024. The Author(s).)
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معلومات مُعتمدة: 868801,844011,675141,652921 Futurum - Akademin för Hälsa och Vård, Region Jönköpings läns; 171109-1 Stiftelsen klinisk cancerforskning i Jönköping; CAN2017-477,20 0750 PjF Swedish Cancer Foundation; TUAGBG-918281 TUA Research Funding
فهرسة مساهمة: Keywords: Head and neck cancer; Health related quality of life; Oral hygiene; Oral mucositis; Radiotherapy; Saliva
تواريخ الأحداث: Date Created: 20240615 Date Completed: 20240616 Latest Revision: 20240618
رمز التحديث: 20240618
مُعرف محوري في PubMed: PMC11180409
DOI: 10.1186/s12903-024-04466-5
PMID: 38879501
قاعدة البيانات: MEDLINE
الوصف
تدمد:1472-6831
DOI:10.1186/s12903-024-04466-5