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Phylodynamics of avian influenza A(H5N1) viruses from outbreaks in Brazil.

التفاصيل البيبلوغرافية
العنوان: Phylodynamics of avian influenza A(H5N1) viruses from outbreaks in Brazil.
المؤلفون: Rivetti AV Jr; Ministério da Agricultura e Pecuária, Laboratório Federal de Defesa Agropecuária/MG, Minas Gerais 33250220, Brazil. Electronic address: anselmo.rivetti@agro.gov.br., Reischak D; Ministério da Agricultura e Pecuária, Laboratório Federal de Defesa Agropecuária/SP, São Paulo 13100-105, Brazil., de Oliveira CHS; Ministério da Agricultura e Pecuária, Laboratório Federal de Defesa Agropecuária/GO, Goiás 74.674-025, Brazil., Otaka JNP; Ministério da Agricultura e Pecuária, Laboratório Federal de Defesa Agropecuária/SP, São Paulo 13100-105, Brazil., Domingues CS; Ministério da Agricultura e Pecuária, Laboratório Federal de Defesa Agropecuária/SP, São Paulo 13100-105, Brazil., Freitas TL; Ministério da Agricultura e Pecuária, Laboratório Federal de Defesa Agropecuária/SP, São Paulo 13100-105, Brazil., Cardoso FG; Ministério da Agricultura e Pecuária, Laboratório Federal de Defesa Agropecuária/SP, São Paulo 13100-105, Brazil., Montesino LO; Ministério da Agricultura e Pecuária, Laboratório Federal de Defesa Agropecuária/SP, São Paulo 13100-105, Brazil., da Silva ALS; Ministério da Agricultura e Pecuária, Laboratório Federal de Defesa Agropecuária/SP, São Paulo 13100-105, Brazil., Camillo SCA; Ministério da Agricultura e Pecuária, Laboratório Federal de Defesa Agropecuária/SP, São Paulo 13100-105, Brazil., Malta F; Hospital Israelita Albert Einstein, São Paulo 05652-900, Brazil., Amgarten D; Hospital Israelita Albert Einstein, São Paulo 05652-900, Brazil., Goés-Neto A; Universidade Federal de Minas Gerais, Instituto de Ciências Biológicas, Minas Gerais 31270-901, Brazil., Aguiar ERGR; Universidade Federal de Minas Gerais, Instituto de Ciências Biológicas, Minas Gerais 31270-901, Brazil., de Almeida IG; Pan American Health Organization: PAHO/WHO - Panaftosa, Minas Gerais 33250220, Brazil., Pinto CA; Ministério da Agricultura e Pecuária, Laboratório Federal de Defesa Agropecuária/MG, Minas Gerais 33250220, Brazil., Fonseca AA Jr; Ministério da Agricultura e Pecuária, Laboratório Federal de Defesa Agropecuária/MG, Minas Gerais 33250220, Brazil., Camargos MF; Ministério da Agricultura e Pecuária, Laboratório Federal de Defesa Agropecuária/MG, Minas Gerais 33250220, Brazil.
المصدر: Virus research [Virus Res] 2024 Sep; Vol. 347, pp. 199415. Date of Electronic Publication: 2024 Jun 19.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Elsevier Science Country of Publication: Netherlands NLM ID: 8410979 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1872-7492 (Electronic) Linking ISSN: 01681702 NLM ISO Abbreviation: Virus Res Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Amsterdam : Elsevier Science, c1984-
مواضيع طبية MeSH: Influenza in Birds*/virology , Influenza in Birds*/epidemiology , Phylogeny* , Influenza A Virus, H5N1 Subtype*/genetics , Influenza A Virus, H5N1 Subtype*/classification , Influenza A Virus, H5N1 Subtype*/isolation & purification , Phylogeography* , Disease Outbreaks*, Animals ; Brazil/epidemiology ; Birds/virology ; Mammals/virology ; Poultry/virology ; Humans ; Genotype ; Neuraminidase/genetics ; Viral Proteins/genetics ; Mutation ; Animals, Wild/virology
مستخلص: Our study identified strains of the A/H5N1 virus in analyzed samples of subsistence poultry, wild birds, and mammals, belonging to clade 2.3.4.4b, genotype B3.2, with very high genetic similarity to strains from Chile, Uruguay, and Argentina. This suggests a migratory route for wild birds across the Pacific, explaining the phylogenetic relatedness. The Brazilian samples displayed similarity to strains that had already been previously detected in South America. Phylogeographic analysis suggests transmission of US viruses from Europe and Asia, co-circulating with other lineages in the American continent. As mutations can influence virulence and host specificity, genomic surveillance is essential to detect those changes, especially in critical regions, such as hot spots in the HA, NA, and PB2 sequences. Mutations in the PB2 gene (D701N and Q591K) associated with adaptation and transmission in mammals were detected suggesting a potential zoonotic risk. Nonetheless, resistance to neuraminidase inhibitors (NAIs) was not identified, however, continued surveillance is crucial to detect potential resistance. Our study also mapped the spread of the virus in the Southern hemisphere, identifying possible entry routes and highlighting the importance of surveillance to prevent outbreaks and protect both human and animal populations.
Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2024. Published by Elsevier B.V.)
فهرسة مساهمة: Keywords: Complete genetic characterization, Phylodynamics, Point mutations; Highly pathogenic avian influenza virus; Outbreaks
المشرفين على المادة: EC 3.2.1.18 (Neuraminidase)
0 (Viral Proteins)
تواريخ الأحداث: Date Created: 20240616 Date Completed: 20240725 Latest Revision: 20240725
رمز التحديث: 20240726
مُعرف محوري في PubMed: PMC11239711
DOI: 10.1016/j.virusres.2024.199415
PMID: 38880334
قاعدة البيانات: MEDLINE
الوصف
تدمد:1872-7492
DOI:10.1016/j.virusres.2024.199415