دورية أكاديمية
Structure-activity relationship studies of pyrogallol as a calcineurin/NFAT signaling suppressor.
| العنوان: | Structure-activity relationship studies of pyrogallol as a calcineurin/NFAT signaling suppressor. |
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| المؤلفون: | Mizuguchi H; Laboratory of Pharmacology Faculty of Pharmacy Osaka Ohtani University, Osaka, 584-8540, Japan. Electronic address: mizuguhiro@osaka-ohtani.ac.jp., Ito T; Department of Molecular Pharmacology, Tokushima University, Tokushima, 770-8505, Japan., Nishida K; Department of Molecular Pharmacology, Tokushima University, Tokushima, 770-8505, Japan., Wakugawa T; Department of Molecular Pharmacology, Tokushima University, Tokushima, 770-8505, Japan., Nakano T; Department of Molecular Pharmacology, Tokushima University, Tokushima, 770-8505, Japan., Tanabe A; Laboratory of Pharmacology Faculty of Pharmacy Osaka Ohtani University, Osaka, 584-8540, Japan., Watano T; Laboratory of Pharmacology Faculty of Pharmacy Osaka Ohtani University, Osaka, 584-8540, Japan., Kitamura N; Allergy and Immunology Project, The Tokyo Metropolitan Institute of Medical Science, Tokyo, 156-8506, Japan., Kaminuma O; Department of Disease Model Research Institute of Radiation Biology and Medicine, Hiroshima University, Hiroshima, 734-8553, Japan., Kimura K; Food Microbiology and Function Research Laboratories, R & D Division. Meiji Co., Ltd., Tokyo, 192-0919, Japan., Ishida T; Faculty of Health and Sports Sciences, Toyo University, Tokyo, 115-8650, Japan., Matsunaga A; Ohkita Medical Clinic, Osaka, 530-0001, Japan., Ohta K; Ohta Child Allergy Clinic, Kyoto, 607-8152, Japan., Shimono R; Pure Med LTd., Osaka, 530-0001, Japan., Kutsuna H; Medical Corporation Kinshukai, Osaka, 558-0011, Japan., Yasuda T; Medical Corporation Kinshukai, Osaka, 558-0011, Japan., Yabumoto M; Medical Corporation Kinshukai, Osaka, 558-0011, Japan., Kitamura Y; Department of Otolaryngology, Institute of Biomedical Sciences, Tokushima University Graduate School, Tokushima, 770-8505, Japan., Takeda N; Department of Otolaryngology, Institute of Biomedical Sciences, Tokushima University Graduate School, Tokushima, 770-8505, Japan., Fukui H; Laboratory of Pharmacology Faculty of Pharmacy Osaka Ohtani University, Osaka, 584-8540, Japan; Medical Corporation Kinshukai, Osaka, 558-0011, Japan. |
| المصدر: | Journal of pharmacological sciences [J Pharmacol Sci] 2024 Aug; Vol. 155 (4), pp. 140-147. Date of Electronic Publication: 2024 Jun 03. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Japanese Pharmacological Society Country of Publication: Japan NLM ID: 101167001 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1347-8648 (Electronic) Linking ISSN: 13478613 NLM ISO Abbreviation: J Pharmacol Sci Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Kyoto, Japan : Japanese Pharmacological Society, c2003- |
| مواضيع طبية MeSH: | Pyrogallol*/pharmacology , Calcineurin*/metabolism , Signal Transduction*/drug effects , NFATC Transcription Factors*/metabolism , Antioxidants*/pharmacology, Structure-Activity Relationship ; Humans ; Gallic Acid/pharmacology ; Gene Expression/drug effects ; Animals ; Phosphorylation/drug effects ; Up-Regulation/drug effects ; Rats |
| مستخلص: | Previously, we have shown that pyrogallol alleviated nasal symptoms and suppressed IL-9 gene up-regulation in allergy model rats by inhibiting calcineurin/NFAT signaling. As pyrogallol has antioxidative activity, it may be responsible for inhibiting calcineurin/NFAT signaling-mediated IL-9 gene expression. However, the relationship between antioxidative activity and suppression of IL-9 gene expression has not been elucidated yet. Here, we conducted the structure-activity relationship studies of pyrogallol and its structurally related compounds to understand the mechanism of IL-9 gene suppression by pyrogallol. 2, 2-Diphenyl-1-picrylhydrazyl radical scavenging assay showed that the antioxidative activity of catechol, resorcinol, phloroglucinol, and gallic acid is 60.1%, 10.4%, 18.8%, and 113.5% of pyrogallol, respectively. Catechol, resorcinol, and phloroglucinol did not suppress NFAT dephosphorylation. Gallic acid suppressed dephosphorylation of NFAT. Gallic acid also suppressed ionomycin-induced up-regulation of IL-9 gene expression with the IC Competing Interests: Declaration of competing interest The authors declare no conflicts of interest. (Copyright © 2024 The Authors. Production and hosting by Elsevier B.V. All rights reserved.) |
| فهرسة مساهمة: | Keywords: Anti-allergic activity; Antioxidative activity; Calcineurin/NFAT signaling; Dephosphorylation of NFAT; IL-9 gene expression |
| المشرفين على المادة: | 01Y4A2QXY0 (Pyrogallol) EC 3.1.3.16 (Calcineurin) 0 (NFATC Transcription Factors) 0 (Antioxidants) 632XD903SP (Gallic Acid) |
| تواريخ الأحداث: | Date Created: 20240616 Date Completed: 20240616 Latest Revision: 20240616 |
| رمز التحديث: | 20240617 |
| DOI: | 10.1016/j.jphs.2024.06.002 |
| PMID: | 38880548 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1347-8648 |
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| DOI: | 10.1016/j.jphs.2024.06.002 |