دورية أكاديمية
Spontaneous remission of a pulmonary sclerosing epithelioid fibrosarcoma: a case report of a possible abscopal effect.
| العنوان: | Spontaneous remission of a pulmonary sclerosing epithelioid fibrosarcoma: a case report of a possible abscopal effect. |
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| المؤلفون: | Campos Ramírez SE; Department of Medical Oncology, University Hospital Miguel Servet, Zaragoza, Spain., Gómez Mateo MC; Department of Pathology, University Hospital Miguel Servet, Zaragoza, Spain., Ruffini Egea SE; Department of Medical Oncology, University Hospital Miguel Servet, Zaragoza, Spain., Monreal Cepero ML; Department of Medical Oncology, University Hospital Miguel Servet, Zaragoza, Spain., Gómez Mugarza P; Department of Medical Oncology, University Hospital Miguel Servet, Zaragoza, Spain., Barriendos Sanz S; Department of Medical Oncology, University Hospital Miguel Servet, Zaragoza, Spain., Martinez Trufero J; Department of Medical Oncology, University Hospital Miguel Servet, Zaragoza, Spain. |
| المصدر: | Translational cancer research [Transl Cancer Res] 2024 May 31; Vol. 13 (5), pp. 2564-2570. Date of Electronic Publication: 2024 May 21. |
| نوع المنشور: | Case Reports; Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Pioneer Bioscience Publishing Company Country of Publication: China NLM ID: 101585958 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2219-6803 (Electronic) Linking ISSN: 2218676X NLM ISO Abbreviation: Transl Cancer Res Subsets: PubMed not MEDLINE |
| أسماء مطبوعة: | Original Publication: [Hong Kong] : Pioneer Bioscience Publishing Company, [2012]- |
| مستخلص: | Background: Spontaneous remission (SR) is defined as the complete or partial disappearance of a diagnosed malignant disease in the absence of known active medical treatment. The role of the immune system is thought to be important, but has not yet been elucidated. On this matter, there are studies that suggest that the abscopal effect (AE), which is defined as the remission of untreated lesions beyond the irradiated area, may be explained by the activation of a systemic immune response against the tumor. Sclerosing epithelioid fibrosarcoma (SEF) is a rare variant of soft tissue sarcoma that is characterized by a slow evolution, with local recurrences and late metastases. The treatment is based on surgery, leaving a minimal role to chemotherapy (ChT) and radiotherapy (RT) for metastatic unresectable disease, and no cases of SR have been reported in the literature so far. Case Description: We present the case of a patient with a lung metastatic recurrence of SEF, diagnosed and treated with surgery 8 years before. After progression to pazopanib and other ChT drugs, because of the chest pain associated with a pleural mass invading the second costal arch, the patient received antalgic local RT treatment. Months later, and without any further treatment, a partial remission of all the tumoral lesions was presented, and she is alive 25 years after the first diagnosis. Conclusions: As far as reported in the literature, this is the first case of SR in SEF. Among the possible causes of this SR, we think that the most plausible is that palliative treatment with RT of the pleural mass induced an AE, leading to a reduction of all tumoral lesions, even those outside the irradiated region. Competing Interests: Conflicts of Interest: All authors have completed the ICMJE uniform disclosure form (available at https://tcr.amegroups.com/article/view/10.21037/tcr-23-2276/coif). J.M.T. is currently serving as an unpaid editorial board member of Translational Cancer Research from June 2023 to May 2025. The other authors have no conflicts of interest to declare. (2024 Translational Cancer Research. All rights reserved.) |
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| فهرسة مساهمة: | Keywords: Sclerosing epithelioid fibrosarcoma (SEF); abscopal effect (AE); case report; spontaneous remission (SR) |
| تواريخ الأحداث: | Date Created: 20240617 Latest Revision: 20240618 |
| رمز التحديث: | 20240618 |
| مُعرف محوري في PubMed: | PMC11170534 |
| DOI: | 10.21037/tcr-23-2276 |
| PMID: | 38881927 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 2219-6803 |
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| DOI: | 10.21037/tcr-23-2276 |