دورية أكاديمية
Enhanced identification of endocrine disruptors through integration of science-based regulatory practices and innovative methodologies: The MERLON Project.
| العنوان: | Enhanced identification of endocrine disruptors through integration of science-based regulatory practices and innovative methodologies: The MERLON Project. |
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| المؤلفون: | Svingen T; National Food Institute, Technical University of Denmark, Kgs. Lyngby, Region Hovedstaden, 2800, Denmark., Andersson AM; Department of Growth and Reproduction, Copenhagen University Hospital (Rigshospitalet), Copenhagen, Denmark.; International Center for Research and Training in Endocrine Disruption of Male Reproduction and Child Health (EDMaRC), Copenhagen University Hospital (Rigshospitalet), Copenhagen, Denmark., Angelova J; Health and Environment Alliance (HEAL), Brussels, Belgium., Axelstad M; National Food Institute, Technical University of Denmark, Kgs. Lyngby, Region Hovedstaden, 2800, Denmark., Bakker J; Neuroendocrinology Laboratory, GIGA-Neurosciences, University of Liege, Liege, Belgium., Baumann L; Environmental Health and Toxicology, Amsterdam Institute for Life and Environment, Vrije Universiteit Amsterdam, Amsterdam, North Holland, 2800, The Netherlands., Beronius A; Institute of Environmental Medicine, Karolinska Institutet, Stockholm, 17177, Sweden., Bouftas N; Environmental Health and Toxicology, Amsterdam Institute for Life and Environment, Vrije Universiteit Amsterdam, Amsterdam, North Holland, 2800, The Netherlands., Chalmel F; Univ Rennes, Inserm, Irset (Institut de recherche en santé, environnement et travail), Rennes, F-25000, France., Christiansen S; National Food Institute, Technical University of Denmark, Kgs. Lyngby, Region Hovedstaden, 2800, Denmark., Cornil C; Neuroendocrinology Laboratory, GIGA-Neurosciences, University of Liege, Liege, Belgium., Damdimopoulou P; Department of Clinical Science, Intervention and Technology, Karolinska Institutet, Huddinge, 14186, Sweden.; Department of Gynecology and Reproductive Medicine, Karolinska Institutet, Huddinge, 14186, Sweden., Deepika D; IISPV, Departament d' Enginyeria Quimica, Universitat Rovira i Virgili, Tarragona, Catalonia, 43007, Spain., Dollé MET; Centre for Health Protection, National Institute for Public Health and the Environment (RIVM), Bilthoven, The Netherlands., Draskau MK; National Food Institute, Technical University of Denmark, Kgs. Lyngby, Region Hovedstaden, 2800, Denmark., Fischer MB; Department of Growth and Reproduction, Copenhagen University Hospital (Rigshospitalet), Copenhagen, Denmark.; International Center for Research and Training in Endocrine Disruption of Male Reproduction and Child Health (EDMaRC), Copenhagen University Hospital (Rigshospitalet), Copenhagen, Denmark., Hagen CP; Department of Growth and Reproduction, Copenhagen University Hospital (Rigshospitalet), Copenhagen, Denmark.; International Center for Research and Training in Endocrine Disruption of Male Reproduction and Child Health (EDMaRC), Copenhagen University Hospital (Rigshospitalet), Copenhagen, Denmark., Hessel E; Centre for Health Protection, National Institute for Public Health and the Environment (RIVM), Bilthoven, The Netherlands., Holmer ML; National Food Institute, Technical University of Denmark, Kgs. Lyngby, Region Hovedstaden, 2800, Denmark., Hughes S; Environmental Health and Toxicology, Amsterdam Institute for Life and Environment, Vrije Universiteit Amsterdam, Amsterdam, North Holland, 2800, The Netherlands., Jensen G; Health and Environment Alliance (HEAL), Brussels, Belgium., Johansson HKL; National Food Institute, Technical University of Denmark, Kgs. Lyngby, Region Hovedstaden, 2800, Denmark., Juul A; Department of Growth and Reproduction, Copenhagen University Hospital (Rigshospitalet), Copenhagen, Denmark.; International Center for Research and Training in Endocrine Disruption of Male Reproduction and Child Health (EDMaRC), Copenhagen University Hospital (Rigshospitalet), Copenhagen, Denmark.; Department of Clinical Medicine, Copenhagen University Hospital (Rigshospitalet), Copenhagen, Denmark., Kumar V; IISPV, Departament d' Enginyeria Quimica, Universitat Rovira i Virgili, Tarragona, Catalonia, 43007, Spain., Kumar S; IISPV, Departament d' Enginyeria Quimica, Universitat Rovira i Virgili, Tarragona, Catalonia, 43007, Spain., Lardenois A; Univ Rennes, Inserm, Irset (Institut de recherche en santé, environnement et travail), Rennes, F-25000, France., Main KM; Department of Growth and Reproduction, Copenhagen University Hospital (Rigshospitalet), Copenhagen, Denmark.; International Center for Research and Training in Endocrine Disruption of Male Reproduction and Child Health (EDMaRC), Copenhagen University Hospital (Rigshospitalet), Copenhagen, Denmark.; Department of Clinical Medicine, Copenhagen University Hospital (Rigshospitalet), Copenhagen, Denmark., Mazaud-Guittot S; Univ Rennes, Inserm, Irset (Institut de recherche en santé, environnement et travail), Rennes, F-25000, France., Moe SJ; Norwegian Institute for Water Research (NIVA), Oslo, 0579, Norway., Mola G; Department of Growth and Reproduction, Copenhagen University Hospital (Rigshospitalet), Copenhagen, Denmark.; International Center for Research and Training in Endocrine Disruption of Male Reproduction and Child Health (EDMaRC), Copenhagen University Hospital (Rigshospitalet), Copenhagen, Denmark., Parent AS; Neuroendocrinology Laboratory, GIGA-Neurosciences, University of Liege, Liege, Belgium., Pineda R; Department of Cell Biology, Physiology and Immunology / IMIBIC., University of Cordoba, Cordoba, 14012, Spain., Rolland A; Institute of Environmental Medicine, Karolinska Institutet, Stockholm, 17177, Sweden., Rosenmai AK; National Food Institute, Technical University of Denmark, Kgs. Lyngby, Region Hovedstaden, 2800, Denmark., Song Y; Norwegian Institute for Water Research (NIVA), Oslo, 0579, Norway., Suglia A; Univ Rennes, Inserm, Irset (Institut de recherche en santé, environnement et travail), Rennes, F-25000, France., Tena-Sempere M; Department of Cell Biology, Physiology and Immunology / IMIBIC., University of Cordoba, Cordoba, 14012, Spain., Wehrli L; Department of Clinical Science, Intervention and Technology, Karolinska Institutet, Huddinge, 14186, Sweden.; Department of Gynecology and Reproductive Medicine, Karolinska Institutet, Huddinge, 14186, Sweden., Zilliacus J; Institute of Environmental Medicine, Karolinska Institutet, Stockholm, 17177, Sweden., van Duursen M; Environmental Health and Toxicology, Amsterdam Institute for Life and Environment, Vrije Universiteit Amsterdam, Amsterdam, North Holland, 2800, The Netherlands. |
| المصدر: | Open research Europe [Open Res Eur] 2024 Apr 12; Vol. 4, pp. 68. Date of Electronic Publication: 2024 Apr 12 (Print Publication: 2024). |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: European Commission Country of Publication: Belgium NLM ID: 9918230081006676 Publication Model: eCollection Cited Medium: Internet ISSN: 2732-5121 (Electronic) Linking ISSN: 27325121 NLM ISO Abbreviation: Open Res Eur Subsets: PubMed not MEDLINE |
| أسماء مطبوعة: | Original Publication: [Brussels] : European Commission, [2021]- |
| مستخلص: | The prevalence of hormone-related health issues caused by exposure to endocrine disrupting chemicals (EDCs) is a significant, and increasing, societal challenge. Declining fertility rates together with rising incidence rates of reproductive disorders and other endocrine-related diseases underscores the urgency in taking more action. Addressing the growing threat of EDCs in our environment demands robust and reliable test methods to assess a broad variety of endpoints relevant for endocrine disruption. EDCs also require effective regulatory frameworks, especially as the current move towards greater reliance on non-animal methods in chemical testing puts to test the current paradigm for EDC identification, which requires that an adverse effect is observed in an intact organism. Although great advances have been made in the field of predictive toxicology, disruption to the endocrine system and subsequent adverse health effects may prove particularly difficult to predict without traditional animal models. The MERLON project seeks to expedite progress by integrating multispecies molecular research, new approach methodologies (NAMs), human clinical epidemiology, and systems biology to furnish mechanistic insights and explore ways forward for NAM-based identification of EDCs. The focus is on sexual development and function, from foetal sex differentiation of the reproductive system through mini-puberty and puberty to sexual maturity. The project aims are geared towards closing existing knowledge gaps in understanding the effects of EDCs on human health to ultimately support effective regulation of EDCs in the European Union and beyond. Competing Interests: No competing interests were disclosed. (Copyright: © 2024 Svingen T et al.) |
| References: | Neuroendocrinology. 2023;113(12):1215-1231. (PMID: 37903467) J Clin Endocrinol Metab. 2022 May 17;107(6):1560-1568. (PMID: 35225342) Environ Int. 2020 Nov;144:106025. (PMID: 32798799) ALTEX. 2022 Oct 12;40(2):287-298. (PMID: 36317504) Endocrinology. 2022 Oct 1;163(10):. (PMID: 35939362) Best Pract Res Clin Endocrinol Metab. 2021 Sep;35(5):101579. (PMID: 34563408) J Clin Invest. 2008 Apr;118(4):1479-90. (PMID: 18340380) Front Endocrinol (Lausanne). 2022 Dec 01;13:1048660. (PMID: 36531497) Lancet Diabetes Endocrinol. 2020 Aug;8(8):719-730. (PMID: 32707119) Front Toxicol. 2023 May 09;5:1183824. (PMID: 37229356) Acta Obstet Gynecol Scand. 2021 Oct;100(10):1800-1805. (PMID: 34296426) Sci Rep. 2016 Jan 27;6:19789. (PMID: 26813099) Biochem Soc Trans. 2020 Aug 28;48(4):1725-1735. (PMID: 32779695) Lancet Diabetes Endocrinol. 2023 Mar;11(3):203-216. (PMID: 36620967) Arch Sex Behav. 2014 Feb;43(2):377-85. (PMID: 23857516) Integr Environ Assess Manag. 2021 Jan;17(1):147-164. (PMID: 32965776) Sci Rep. 2021 Aug 9;11(1):16168. (PMID: 34373498) Environ Pollut. 2022 Jul 1;304:119242. (PMID: 35378198) Hum Reprod. 2001 May;16(5):972-8. (PMID: 11331648) Horm Res Paediatr. 2014;82(2):73-80. (PMID: 25012863) Neurosci Biobehav Rev. 2021 Feb;121:29-46. (PMID: 33248148) Environ Health Perspect. 2018 Sep;126(9):97004. (PMID: 30203993) Curr Res Toxicol. 2021 Apr 01;2:179-191. (PMID: 34345859) J Neuroendocrinol. 2022 Feb;34(2):e13050. (PMID: 34708466) Front Toxicol. 2024 Mar 26;6:1357717. (PMID: 38601197) J Clin Endocrinol Metab. 2022 Aug 18;107(9):2598-2605. (PMID: 35704034) Vitam Horm. 2014;94:327-48. (PMID: 24388196) Int J Transgend Health. 2022 Sep 6;23(Suppl 1):S1-S259. (PMID: 36238954) Toxicol Sci. 2014 Dec;142(2):312-20. (PMID: 25466378) Arch Sex Behav. 2015 Jul;44(5):1281-7. (PMID: 25588709) Eur J Endocrinol. 2006 Jan;154(1):125-9. (PMID: 16382001) Arch Toxicol. 2019 Feb;93(2):253-272. (PMID: 30430187) Hum Reprod Update. 2022 Aug 25;28(5):687-716. (PMID: 35466359) Asian J Androl. 2015 May-Jun;17(3):415-20. (PMID: 25652637) J Clin Endocrinol Metab. 2022 Jun 16;107(7):1965-1975. (PMID: 35323957) Handb Clin Neurol. 2021;181:427-443. (PMID: 34238476) EFSA J. 2018 Jun 07;16(6):e05311. (PMID: 32625944) Sci Total Environ. 2021 May 15;769:145119. (PMID: 33477047) J Clin Endocrinol Metab. 2011 Nov;96(11):3432-9. (PMID: 21900380) Mol Reprod Dev. 2022 Dec;89(12):608-631. (PMID: 36580349) Physiol Rev. 2016 Jan;96(1):55-97. (PMID: 26582516) J Clin Endocrinol Metab. 2000 Dec;85(12):4905-7. (PMID: 11134160) Nat Rev Endocrinol. 2017 Jul;13(7):400-414. (PMID: 28450750) |
| فهرسة مساهمة: | Keywords: adverse outcome pathways; endocrine disruption; gender; new approach methodologies; regulatory toxicology; reproduction; sexual development; systems biology |
| تواريخ الأحداث: | Date Created: 20240617 Latest Revision: 20240618 |
| رمز التحديث: | 20240618 |
| مُعرف محوري في PubMed: | PMC11179054 |
| DOI: | 10.12688/openreseurope.17319.1 |
| PMID: | 38883262 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 2732-5121 |
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| DOI: | 10.12688/openreseurope.17319.1 |