دورية أكاديمية
Donor site wound healing following free gingival graft surgery using platelet rich fibrin: A randomized controlled trial.
| العنوان: | Donor site wound healing following free gingival graft surgery using platelet rich fibrin: A randomized controlled trial. |
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| المؤلفون: | Scott SMH; Department of Periodontics, UT Health San Antonio School of Dentistry, San Antonio, Texas, USA., Lacy JA; Department of Periodontics, UT Health San Antonio School of Dentistry, San Antonio, Texas, USA., Palaiologou AA; Department of Periodontics, UT Health San Antonio School of Dentistry, San Antonio, Texas, USA., Kotsakis GA; Rutgers School of Dental Medicine, Newark, New Jersey, USA., Deas DE; Department of Periodontics, UT Health San Antonio School of Dentistry, San Antonio, Texas, USA., Mealey BL; Department of Periodontics, UT Health San Antonio School of Dentistry, San Antonio, Texas, USA. |
| المصدر: | Journal of periodontology [J Periodontol] 2024 Jul; Vol. 95 (7), pp. 632-639. Date of Electronic Publication: 2024 Jun 17. |
| نوع المنشور: | Journal Article; Randomized Controlled Trial; Comparative Study |
| اللغة: | English |
| بيانات الدورية: | Publisher: American Academy of Periodontology Country of Publication: United States NLM ID: 8000345 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1943-3670 (Electronic) Linking ISSN: 00223492 NLM ISO Abbreviation: J Periodontol Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: [Chicago] American Academy of Periodontology. |
| مواضيع طبية MeSH: | Platelet-Rich Fibrin* , Wound Healing*/drug effects , Gingiva* , Pain Measurement* , Transplant Donor Site*/surgery , Pain, Postoperative* , Hemostatics*/therapeutic use, Humans ; Female ; Male ; Adult ; Middle Aged ; Follow-Up Studies ; Re-Epithelialization ; Analgesics/therapeutic use ; Palate/surgery ; Pain Perception ; Young Adult ; Treatment Outcome ; Granulation Tissue |
| مستخلص: | Background: The primary purpose of this two-arm, parallel design, randomized controlled study is to compare healing of the palatal tissue donor site when platelet-rich fibrin (PRF) is used as a wound dressing compared to the use of a hemostatic agent. Secondary outcomes of patient pain perception and analgesic intake were also evaluated. Methods: Seventy-four patients receiving free gingival grafts were randomized to receive either PRF (test) or hemostatic agent (control) as a palatal wound dressing by patients selecting a sealed envelope containing their group assignment (initially 37 envelopes for PRF group and 37 for hemostatic agent group). Patient pain assessment and analgesic consumption were documented using a 21-point numerical scale (NMRS-21) at 24, 48, and 72 hours post-surgery. At 1-, 2-, 3-, and 4-week follow-up appointments palatal early healing index (PEHI) scores including wound color, epithelialization, presence or absence of swelling, granulation tissue, and bleeding on gentle palpation were generated by direct intraoral examination by a blinded examiner unaware of the patients' treatment group. Results: NMRS-21 pain scores showed a significant reduction in pain over time in both groups, with no significant difference between groups at any time point. No significant between-group difference was found in the amount of analgesics taken by patients at 24, 48, and 72 hours. There was significant improvement in PEHI scores over the 4-week time period in both groups, but there was no significant difference in PEHI score at each time point (1, 2, 3, 4 weeks) between groups. CONCLUSIONS: Study findings suggest that there is no difference in early palatal wound healing, patient pain perception, or analgesic consumption between use of PRF or a hemostatic agent as donor-site wound dressings. (© 2024 American Academy of Periodontology.) |
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| فهرسة مساهمة: | Keywords: hemostatics; pain; palate; platelet‐rich fibrin; tissue grafts; wound healing |
| المشرفين على المادة: | 0 (Hemostatics) 0 (Analgesics) |
| تواريخ الأحداث: | Date Created: 20240617 Date Completed: 20240723 Latest Revision: 20240723 |
| رمز التحديث: | 20240723 |
| DOI: | 10.1002/JPER.24-0072 |
| PMID: | 38884613 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1943-3670 |
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| DOI: | 10.1002/JPER.24-0072 |