دورية أكاديمية
Donor site wound healing following free gingival graft surgery using platelet rich fibrin: A randomized controlled trial.
العنوان: | Donor site wound healing following free gingival graft surgery using platelet rich fibrin: A randomized controlled trial. |
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المؤلفون: | Scott SMH; Department of Periodontics, UT Health San Antonio School of Dentistry, San Antonio, Texas, USA., Lacy JA; Department of Periodontics, UT Health San Antonio School of Dentistry, San Antonio, Texas, USA., Palaiologou AA; Department of Periodontics, UT Health San Antonio School of Dentistry, San Antonio, Texas, USA., Kotsakis GA; Rutgers School of Dental Medicine, Newark, New Jersey, USA., Deas DE; Department of Periodontics, UT Health San Antonio School of Dentistry, San Antonio, Texas, USA., Mealey BL; Department of Periodontics, UT Health San Antonio School of Dentistry, San Antonio, Texas, USA. |
المصدر: | Journal of periodontology [J Periodontol] 2024 Jul; Vol. 95 (7), pp. 632-639. Date of Electronic Publication: 2024 Jun 17. |
نوع المنشور: | Journal Article; Randomized Controlled Trial; Comparative Study |
اللغة: | English |
بيانات الدورية: | Publisher: American Academy of Periodontology Country of Publication: United States NLM ID: 8000345 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1943-3670 (Electronic) Linking ISSN: 00223492 NLM ISO Abbreviation: J Periodontol Subsets: MEDLINE |
أسماء مطبوعة: | Original Publication: [Chicago] American Academy of Periodontology. |
مواضيع طبية MeSH: | Platelet-Rich Fibrin* , Wound Healing*/drug effects , Gingiva* , Pain Measurement* , Transplant Donor Site*/surgery , Pain, Postoperative* , Hemostatics*/therapeutic use, Humans ; Female ; Male ; Adult ; Middle Aged ; Follow-Up Studies ; Re-Epithelialization ; Analgesics/therapeutic use ; Palate/surgery ; Pain Perception ; Young Adult ; Treatment Outcome ; Granulation Tissue |
مستخلص: | Background: The primary purpose of this two-arm, parallel design, randomized controlled study is to compare healing of the palatal tissue donor site when platelet-rich fibrin (PRF) is used as a wound dressing compared to the use of a hemostatic agent. Secondary outcomes of patient pain perception and analgesic intake were also evaluated. Methods: Seventy-four patients receiving free gingival grafts were randomized to receive either PRF (test) or hemostatic agent (control) as a palatal wound dressing by patients selecting a sealed envelope containing their group assignment (initially 37 envelopes for PRF group and 37 for hemostatic agent group). Patient pain assessment and analgesic consumption were documented using a 21-point numerical scale (NMRS-21) at 24, 48, and 72 hours post-surgery. At 1-, 2-, 3-, and 4-week follow-up appointments palatal early healing index (PEHI) scores including wound color, epithelialization, presence or absence of swelling, granulation tissue, and bleeding on gentle palpation were generated by direct intraoral examination by a blinded examiner unaware of the patients' treatment group. Results: NMRS-21 pain scores showed a significant reduction in pain over time in both groups, with no significant difference between groups at any time point. No significant between-group difference was found in the amount of analgesics taken by patients at 24, 48, and 72 hours. There was significant improvement in PEHI scores over the 4-week time period in both groups, but there was no significant difference in PEHI score at each time point (1, 2, 3, 4 weeks) between groups. CONCLUSIONS: Study findings suggest that there is no difference in early palatal wound healing, patient pain perception, or analgesic consumption between use of PRF or a hemostatic agent as donor-site wound dressings. (© 2024 American Academy of Periodontology.) |
References: | Hämmerle CHF, Tarnow D. The etiology of hard‐ and soft‐tissue deficiencies at dental implants: a narrative review. J Periodontol. 2018;89(suppl 1):S291‐S303. doi:10.1002/JPER.16‐0810. Avila‐Ortiz G, Gonzalez‐Martin O, Couso‐Queiruga E, Wang HL. The peri‐implant phenotype. J Periodontol. 2020;91:283‐288. doi:10.1002/JPER.19‐0566. Tavelli L, Barootchi S, Avila‐Ortiz G, Urban IA, Giannobile WV, Wang HL. Peri‐implant soft tissue phenotype modification and its impact on peri‐implant health: a systematic review and network meta‐analysis. J Periodontol. 2021;92:21‐44. doi:10.1002/JPER.19‐0716. Kassab MM, Cohen RE. The etiology and prevalence of gingival recession. J Am Dent Assoc. 2003;134:220‐225. doi:10.14219/jada.archive.2003.0137. Chambrone L, Tatakis DN. Periodontal soft tissue root coverage procedures: a systematic review from the AAP Regeneration Workshop. J Periodontol. 2015;86:S8‐S51. doi:10.1902/jop.2015.130674. Maynard JG Jr, Ochsenbein C. Mucogingival problems, prevalence and therapy in children. J Periodontol. 1975;46:543‐552. doi:10.1902/jop.1975.46.9.543. Lang NP, Loe H. The relationship between the width of keratinized gingiva and gingival health. J Periodontol. 1972;43:623‐627. doi:10.1902/jop.1972.43.10.623. Novaes AB, Ruben MP, Kon S, Goldman HM. The development of the periodontal cleft. A clinical and histopathologic study. J Periodontol. 1975;46:701‐709. doi:10.1902/jop.1975.46.12.701. Alghamdi H, Babay N, Sukumaran A. Surgical management of gingival recession: a clinical update. Saudi Dent J. 2009;21:83‐94. doi:10.1016/j.sdentj.2009.07.006. Kim DM, Neiva R. Periodontal soft tissue non‐root coverage procedures: a systematic review from the AAP Regeneration Workshop. J Periodontol. 2015;86(2 Suppl):S56‐S72. doi:10.1902/jop.2015.130684. Sullivan HC, Atkins JH. Free autogenous gingival grafts. I. Principles of successful grafting. Periodontics. 1968;6(3):121‐129. Zucchelli G, Mele M, Stefanini M, et al. Patient morbidity and root coverage outcome after subepithelial connective tissue and de‐epithelialized grafts: a comparative randomized‐controlled clinical trial. J Clin Periodontol. 2010;37:728‐738. doi:10.1111/j.1600‐051X.2010.01550.x. Bakhishov H, Isler SC, Bozyel B, Yıldırım B, Tekindal MA, Ozdemir B. De‐epithelialized gingival graft versus subepithelial connective tissue graft in the treatment of multiple adjacent gingival recessions using the tunnel technique: 1‐year results of a randomized clinical trial. J Clin Periodontol. 2021;48:970‐983. doi:10.1111/jcpe.13452. Griffin TJ, Cheung WS, Zavras AI, Damoulis PD. Postoperative complications following gingival augmentation procedures. J Periodontol. 2006;77:2070‐2079. doi:10.1902/jop.2006.050296. Keceli HG, Aylikci BU, Koseoglu S, Dolgun A. Evaluation of palatal donor site haemostasis and wound healing after free gingival graft surgery. J Clin Periodontol. 2015;42:582‐589. doi:10.1111/jcpe.12404. Tavelli L, Asa'ad F, Acunzo R, Pagni G, Consonni D, Rasperini G. Minimizing patient morbidity following palatal gingival harvesting: a randomized controlled clinical study. Int J Periodontics Restorative Dent. 2018;38:e127‐e134. doi:10.11607/prd.3581. Ustaoglu G, Ercan E, Tunali M. Low‐level laser therapy in enhancing wound healing and preserving tissue thickness at free gingival graft donor sites: a randomized, controlled clinical study. Photomed Laser Surg. 2017;35:223‐230. doi:10.1089/pho.2016.4163. Isler SC, Uraz A, Guler B, Ozdemir Y, Cula S, Cetiner D. Effects of laser photobiomodulation and ozone therapy on palatal epithelial wound healing and patient morbidity. Photomed Laser Surg. 2018;36:571‐580. doi:10.1089/pho.2018.4492. Kızıltoprak M, Uslu M. Comparison of the effects of injectable platelet‐rich fibrin and autologous fibrin glue applications on palatal wound healing: a randomized controlled clinical trial. Clin Oral Investig. 2020;24:4549‐4561. doi:10.1007/s00784‐020‐03320‐6. Khalil S, Habashneh RA, Alomari S, Alzoubi M. Local application of hyaluronic acid in conjunction with free gingival graft: a randomized clinical trial. Clin Oral Investig. 2022;26:2165‐2174. doi:10.1007/s00784‐021‐04197‐9. Miron RJ, Fujioka‐Kobayashi M, Bishara M, Zhang Y, Hernandez M, Choukroun J. Platelet‐rich fibrin and soft tissue wound healing: a systematic review. Tissue Eng Part B Rev. 2017;23:83‐99. doi:10.1089/ten.TEB.2016.0233. Bahammam MA. Effect of platelet‐rich fibrin palatal bandage on pain scores and wound healing after free gingival graft: a randomized controlled clinical trial. Clin Oral Investig. 2018;22:3179‐3188. doi:10.1007/s00784‐018‐2397‐y. Femminella B, Iaconi MC, Di Tullio M, et al. Clinical comparison of platelet‐rich fibrin and a gelatin sponge in the management of palatal wounds after epithelialized free gingival graft harvest: a randomized clinical trial. J Periodontol. 2016;87:103‐113. doi:10.1902/jop.2015.150198. Ozcan M, Ucak O, Alkaya B, Keceli S, Seydaoglu G, Haytac MC. Effects of platelet‐rich fibrin on palatal wound healing after free gingival graft harvesting: a comparative randomized controlled clinical trial. Int J Periodontics Restorative Dent. 2017;37:e270‐e278. doi:10.11607/prd.3226. Fickl S, Fischer KR, Jockel‐Schneider Y, Stappert CF, Schlagenhauf U, Kebschull M. Early wound healing and patient morbidity after single‐incision vs. trap‐door graft harvesting from the palate—a clinical study. Clin Oral Investig. 2014;18:2213‐2219. doi:10.1007/s00784‐014‐1204‐7. Hamzani Y, Chaushu G. Evaluation of early wound healing scales/indexes in oral surgery: a literature review. Clin Implant Dent Relat Res. 2018;20:1030‐1035. doi:10.1111/cid.12680. Vieth MP, Deas DE, Palaiologou AA, Diogenes A, Mader MJ, Mealey BL. Effect of intravenous dexamethasone on postoperative pain and swelling following periodontal flap surgery: a randomized controlled trial of patient‐centered outcomes. J Periodontol. 2022;93:237‐245. doi:10.1002/JPER.21‐0153. Wyrebek B, Gorski B, Gorska R. Patient morbidity at the palatal donor site depending on gingival graft dimension. Dent Med Probl. 2018;55:153‐159. doi:10.17219/dmp/91406. Basma HS, Saleh MHA, Abou‐Arraj RV, et al. Patient‐reported outcomes of palatal donor site healing using four different wound dressing modalities following free epithelialized mucosal grafts: a four‐arm randomized controlled clinical trial. J Periodontol. 2023;94:88‐97. doi:10.1002/JPER.22‐0172. Patarapongsanti A, Bandhaya P, Sirinirund B, Khongkhunthian S, Khongkhunthian P. Comparison of platelet‐rich fibrin and cellulose in palatal wounds after graft harvesting. J Investig Clin Dent. 2019;10(4):e12467. doi:10.1111/jicd.12467. Rossmann JA, Rees TD. A comparative evaluation of hemostatic agents in the management of soft tissue graft donor site bleeding. J Periodontol. 1999;70:1369‐1375. doi:10.1902/jop.1999.70.11.1369. |
فهرسة مساهمة: | Keywords: hemostatics; pain; palate; platelet‐rich fibrin; tissue grafts; wound healing |
المشرفين على المادة: | 0 (Hemostatics) 0 (Analgesics) |
تواريخ الأحداث: | Date Created: 20240617 Date Completed: 20240723 Latest Revision: 20240723 |
رمز التحديث: | 20240723 |
DOI: | 10.1002/JPER.24-0072 |
PMID: | 38884613 |
قاعدة البيانات: | MEDLINE |
تدمد: | 1943-3670 |
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DOI: | 10.1002/JPER.24-0072 |