دورية أكاديمية
Normotensive metabolic syndrome in Transient Receptor Potential Canonical Channel type 1 Trpc1-/- mice.
| العنوان: | Normotensive metabolic syndrome in Transient Receptor Potential Canonical Channel type 1 Trpc1-/- mice. |
|---|---|
| المؤلفون: | Atkins RM; Department of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA., Pantalia M; Division of Nephrology, Department of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA., Skaggs C; Department of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA., Lau AK; Division of Nephrology, Department of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA., Mahmood MB; Division of Nephrology, Department of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA., Anwar MM; Division of Nephrology, Department of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA., Barron L; Division of Nephrology, Department of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA., Eby B; Division of Nephrology, Department of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA., Khan U; Division of Nephrology, Department of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA., Tsiokas L; Department of Cell Biology, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA., Lau K; Division of Nephrology, Department of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA. |
| المصدر: | Biology open [Biol Open] 2024 Jul 15; Vol. 13 (7). Date of Electronic Publication: 2024 Jul 31. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Company of Biologists Ltd Country of Publication: England NLM ID: 101578018 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2046-6390 (Electronic) Linking ISSN: 20466390 NLM ISO Abbreviation: Biol Open Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Cambridge : Company of Biologists Ltd. |
| مواضيع طبية MeSH: | TRPC Cation Channels*/genetics , TRPC Cation Channels*/metabolism , TRPC Cation Channels*/deficiency , Metabolic Syndrome*/etiology , Metabolic Syndrome*/metabolism , Metabolic Syndrome*/genetics , Mice, Knockout* , Disease Models, Animal*, Animals ; Mice ; Blood Pressure ; Phenotype ; Male ; Female |
| مستخلص: | Metabolic syndrome has become a global epidemic, affecting all developed countries and communities with growing economies. Worldwide, increasing efforts have been directed at curbing this growing problem. Mice deleted of the gene encoding Type 1 Transient Receptor Potential Canonical Channel (Trpc1) were found to weigh heavier than controls. They had fasting hyperglycemia and impaired glucose tolerance compared with wild-type controls. Beyond 1 year of age, plasma triglyceride level in Trpc1-/- mice was elevated. Plasma cholesterol levels tended to be higher than in controls. The livers of Trpc1-/- mice were heavier, richer in triglyceride, and more echogenic than those of controls on ultrasound evaluation. Hematocrit was lower in Trpc1-/- mice of both genders beginning at the second to third months of age in the absence of bleeding or hemolysis. Measured by the indirect tail-cuff method or by the direct arterial cannulation, blood pressures in null mice were lower than controls. We conclude that TRPC1 gene regulates body metabolism and that except for hypertension, phenotypes of mice after deletion of the Trpc1 gene resemble mice with metabolic syndrome, suggesting that this could be a good experimental model for future investigation of the pathogenesis and management of this disorder. Competing Interests: Competing interests The authors declare no competing or financial interests. (© 2024. Published by The Company of Biologists Ltd.) |
| معلومات مُعتمدة: | no # (to KL) Oklahoma Fraternal Order of Eagles; DK121656 NIH grant (to LT); Fraternal Order of Eagles; University of Oklahoma Health Sciences Center |
| فهرسة مساهمة: | Keywords: Animal model; Calcium channel; Diabetes; Metabolic syndrome; TPRC1; Ultrasound |
| المشرفين على المادة: | 0 (TRPC Cation Channels) 0 (transient receptor potential cation channel, subfamily C, member 1) |
| تواريخ الأحداث: | Date Created: 20240617 Date Completed: 20240731 Latest Revision: 20240731 |
| رمز التحديث: | 20240731 |
| DOI: | 10.1242/bio.060280 |
| PMID: | 38885005 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 2046-6390 |
|---|---|
| DOI: | 10.1242/bio.060280 |