دورية أكاديمية
أعرض في EDS

Adiposity in mares induces insulin dysregulation and mitochondrial dysfunction which can be mitigated by nutritional intervention.

التفاصيل البيبلوغرافية
العنوان: Adiposity in mares induces insulin dysregulation and mitochondrial dysfunction which can be mitigated by nutritional intervention.
المؤلفون: Fresa K; Department of Biomedical Sciences, Colorado State University, Fort Collins, CO, 80523, USA., Catandi GD; Department of Biomedical Sciences, Colorado State University, Fort Collins, CO, 80523, USA., Whitcomb L; Department of Biomedical Sciences, Colorado State University, Fort Collins, CO, 80523, USA., Gonzalez-Castro RA; Department of Biomedical Sciences, Colorado State University, Fort Collins, CO, 80523, USA., Chicco AJ; Department of Biomedical Sciences, Colorado State University, Fort Collins, CO, 80523, USA., Carnevale EM; Department of Biomedical Sciences, Colorado State University, Fort Collins, CO, 80523, USA. elaine.carnevale@colostate.edu.
المصدر: Scientific reports [Sci Rep] 2024 Jun 18; Vol. 14 (1), pp. 13992. Date of Electronic Publication: 2024 Jun 18.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE
أسماء مطبوعة: Original Publication: London : Nature Publishing Group, copyright 2011-
مواضيع طبية MeSH: Insulin*/metabolism , Insulin*/blood , Carnitine*/metabolism , Carnitine*/pharmacology , Obesity*/metabolism , Obesity*/diet therapy , Dietary Supplements* , Adiposity*/drug effects, Animals ; Horses ; Female ; Mitochondria/metabolism ; Mitochondria/drug effects ; Muscle, Skeletal/metabolism ; Muscle, Skeletal/drug effects ; Lipid Metabolism/drug effects ; Horse Diseases/metabolism ; Horse Diseases/diet therapy ; Horse Diseases/etiology ; Insulin Resistance ; Reactive Oxygen Species/metabolism
مستخلص: Obesity is a complex disease associated with augmented risk of metabolic disorder development and cellular dysfunction in various species. The goal of the present study was to investigate the impacts of obesity on the metabolic health of old mares as well as test the ability of diet supplementation with either a complex blend of nutrients designed to improve equine metabolism and gastrointestinal health or L-carnitine alone to mitigate negative effects of obesity. Mares (n = 19, 17.9 ± 3.7 years) were placed into one of three group: normal-weight (NW, n = 6), obese (OB, n = 7) or obese fed a complex diet supplement for 12 weeks (OBD, n = 6). After 12 weeks and completion of sample collections, OB mares received L-carnitine alone for an additional 6 weeks. Obesity in mares was significantly associated with insulin dysregulation, reduced muscle mitochondrial function, and decreased skeletal muscle oxidative capacity with greater ROS production when compared to NW. Obese mares fed the complex diet supplement had better insulin sensivity, greater cell lipid metabolism, and higher muscle oxidative capacity with reduced ROS production than OB. L-carnitine supplementation alone did not significantly alter insulin signaling, but improved lipid metabolism and muscle oxidative capacity with reduced ROS. In conclusion, obesity is associated with insulin dysregulation and altered skeletal muscle metabolism in older mares. However, dietary interventions are an effective strategy to improve metabolic status and skeletal muscle mitochondrial function in older mares.
(© 2024. The Author(s).)
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معلومات مُعتمدة: Grant No. COLV 2021-09/Project Accession No. 1026913 USDA National Institute of Food and Agriculture Animal Health and Disease
فهرسة مساهمة: Keywords: Equine; Insulin dysregulation; Metabolism; Mitochondrial dysfunction; Muscle; Obesity; Systemic
المشرفين على المادة: 0 (Insulin)
S7UI8SM58A (Carnitine)
0 (Reactive Oxygen Species)
تواريخ الأحداث: Date Created: 20240617 Date Completed: 20240617 Latest Revision: 20240703
رمز التحديث: 20240703
مُعرف محوري في PubMed: PMC11183153
DOI: 10.1038/s41598-024-64628-x
PMID: 38886475
قاعدة البيانات: MEDLINE
الوصف
تدمد:2045-2322
DOI:10.1038/s41598-024-64628-x