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Epigallocatechin-3-gallate ameliorates lipopolysaccharide-induced acute thymus involution in mice via AMPK/Sirt1 pathway.

التفاصيل البيبلوغرافية
العنوان: Epigallocatechin-3-gallate ameliorates lipopolysaccharide-induced acute thymus involution in mice via AMPK/Sirt1 pathway.
المؤلفون: Su Q; Department of Histology and Embryology, School of Basic Medical Sciences, Zhengzhou University, Zhengzhou, Henan, PR China.; The Second Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, PR China., Yang SP; Department of Histology and Embryology, School of Basic Medical Sciences, Zhengzhou University, Zhengzhou, Henan, PR China.; School of Medical Technology, Sanquan College of Xinxiang Medical University, Xinxiang, Henan, PR China., Guo JP; Department of Histology and Embryology, School of Basic Medical Sciences, Zhengzhou University, Zhengzhou, Henan, PR China., Rong YR; Department of Histology and Embryology, School of Basic Medical Sciences, Zhengzhou University, Zhengzhou, Henan, PR China., Sun Y; Department of Histology and Embryology, School of Basic Medical Sciences, Zhengzhou University, Zhengzhou, Henan, PR China., Chai YR; Department of Histology and Embryology, School of Basic Medical Sciences, Zhengzhou University, Zhengzhou, Henan, PR China.
المصدر: Microbiology and immunology [Microbiol Immunol] 2024 Aug; Vol. 68 (8), pp. 281-293. Date of Electronic Publication: 2024 Jun 17.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Wiley-Blackwell Country of Publication: Australia NLM ID: 7703966 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1348-0421 (Electronic) Linking ISSN: 03855600 NLM ISO Abbreviation: Microbiol Immunol Subsets: MEDLINE
أسماء مطبوعة: Publication: <2008- > : Richmond : Wiley-Blackwell
Original Publication: 1977-<2007> : Tokyo : Center for Academic Publications Japan.
مواضيع طبية MeSH: Catechin*/analogs & derivatives , Catechin*/pharmacology , Sirtuin 1*/metabolism , Lipopolysaccharides* , Thymus Gland*/drug effects , Thymus Gland*/metabolism , Signal Transduction*/drug effects , AMP-Activated Protein Kinases*/metabolism, Animals ; Mice ; Female ; Reactive Oxygen Species/metabolism ; Antioxidants/pharmacology ; Membrane Potential, Mitochondrial/drug effects ; Atrophy
مستخلص: The thymus, a site to culture the naïve T lymphocytes, is susceptible to atrophy or involution due to aging, inflammation, and oxidation. Epigallocatechin-3-gallate (EGCG) has been proven to possess anti-inflammatory, antioxidant, and antitumor activity. Here, we investigate the effects of EGCG on thymic involution induced by lipopolysaccharide (LPS), an endotoxin derived from Gram-negative bacteria. The methodology included an in vivo experiment on female Kunming mice exposed to LPS and EGCG. Morphological assessment of thymic involution, immunohistochemical detection, and thymocyte subsets analysis by flow cytometry were further carried out to evaluate the potential role of EGCG on the thymus. As a result, we found that EGCG alleviated LPS-induced thymic atrophy, increased mitochondrial membrane potential and superoxide dismutase levels, and decreased malondialdehyde and reactive oxygen species levels. In addition, EGCG pre-supplement restored the ratio of thymocyte subsets, the expression of autoimmune regulator, sex-determining region Y-box 2, and Nanog homebox, and reduced the number of senescent cells and collagen fiber deposition. Western blotting results indicated that EGCG treatment elevated LPS-induced decrease in pAMPK, Sirt1 protein expression. Collectively, EGCG relieved thymus architecture and function damaged by LPS via regulation of AMPK/Sirt1 signaling pathway. Our findings may provide a new strategy on protection of thymus from involution caused by LPS by using EGCG. And EGCG might be considered as a potential agent for the prevention and treatment of thymic involution.
(© 2024 The Societies and John Wiley & Sons Australia, Ltd.)
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معلومات مُعتمدة: 21A310022 Key Scientific Research Project of Higher Education Institution
فهرسة مساهمة: Keywords: AMPK/Sirt1; epigallocatechin‐3‐gallate; lipopolysaccharide; thymocytes; thymus
المشرفين على المادة: 8R1V1STN48 (Catechin)
BQM438CTEL (epigallocatechin gallate)
EC 3.5.1.- (Sirtuin 1)
0 (Lipopolysaccharides)
EC 3.5.1.- (Sirt1 protein, mouse)
EC 2.7.11.31 (AMP-Activated Protein Kinases)
0 (Reactive Oxygen Species)
0 (Antioxidants)
تواريخ الأحداث: Date Created: 20240617 Date Completed: 20240805 Latest Revision: 20240805
رمز التحديث: 20240805
DOI: 10.1111/1348-0421.13159
PMID: 38886542
قاعدة البيانات: MEDLINE
الوصف
تدمد:1348-0421
DOI:10.1111/1348-0421.13159