دورية أكاديمية
أعرض في EDS

Survival of Metastatic Human Papillomavirus (HPV)-Related Head and Neck Cancer Receiving Platinum-Based Triplet Induction Chemotherapy and Relevance of Circulating Tumor HPV DNA.

التفاصيل البيبلوغرافية
العنوان: Survival of Metastatic Human Papillomavirus (HPV)-Related Head and Neck Cancer Receiving Platinum-Based Triplet Induction Chemotherapy and Relevance of Circulating Tumor HPV DNA.
المؤلفون: Eguchi H; Head and Neck Surgery, Osaka University, Suita, JPN., Takenaka Y; Head and Neck Surgery, Osaka University, Suita, JPN., Tanaka H; Head and Neck Surgery, Osaka University, Suita, JPN., Suzuki M; Head and Neck Surgery, Osaka University, Suita, JPN., Horie M; Basic Sciences, Osaka University, Suita, JPN., Kanai H; Head and Neck Surgery, Osaka University, Suita, JPN., Seo Y; Radiation Oncology, Osaka University, Suita, JPN., Ogawa K; Radiation Oncology, Osaka University, Suita, JPN., Yachida S; Basic Sciences, Osaka University, Suita, JPN., Inohara H; Otorhinolaryngology - Head and Neck Surgery, Osaka University Graduate School of Medicine, Suita, JPN.
المصدر: Cureus [Cureus] 2024 May 18; Vol. 16 (5), pp. e60547. Date of Electronic Publication: 2024 May 18 (Print Publication: 2024).
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Cureus, Inc Country of Publication: United States NLM ID: 101596737 Publication Model: eCollection Cited Medium: Print ISSN: 2168-8184 (Print) Linking ISSN: 21688184 NLM ISO Abbreviation: Cureus Subsets: PubMed not MEDLINE
أسماء مطبوعة: Original Publication: Palo Alto, CA : Cureus, Inc.
مستخلص: Objectives We aimed to examine the effectiveness of platinum-based triplet induction chemotherapy in metastatic squamous cell carcinoma of the head and neck (HNSCC) at diagnosis in terms of tumor human papillomavirus (HPV) status and the clinical relevance of circulating tumor HPV DNA (ctHPVDNA) during induction chemotherapy. Methods  Twenty-one patients were included. ctHPVDNA was longitudinally quantified using optimized digital PCR in a subset of patients. Results HPV-related HNSCC patients (N=7) had a significantly better response to induction chemotherapy than HPV-unrelated HNSCC patients (N=14) (complete or partial response rate, 100% vs. 36%, P = 0.007). Following induction chemotherapy, more HPV-related HNSCC patients than HPV-unrelated patients received radiotherapy (86% vs. 36%, P = 0.06). With a median follow-up of 26 months in surviving patients, the two-year overall survival was 86% in HPV-related HNSCC patients and 43% in HPV-unrelated HNSCC patients ( P = 0.04). In two patients, ctHPVDNA levels drastically decreased after the first cycle of induction chemotherapy but turned to continuous increase after the second cycle, suggesting the acquisition of drug resistance by the end of the second cycle. Radiographic imaging after induction chemotherapy failed to identify the drug resistance. In one patient, ctHPVDNA decreased gradually but remained detectable after induction chemotherapy despite no radiographic residual disease. ctHPVDNA became undetectable during radiotherapy. Conclusion HPV-related HNSCC patients with distant metastasis at diagnosis should be treated definitively. The ctHPVDNA level reflects real-time disease activity. ctHPVDNA monitoring during induction chemotherapy could help the decision-making of the therapeutic strategy.
Competing Interests: The authors have declared that no competing interests exist.
(Copyright © 2024, Eguchi et al.)
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فهرسة مساهمة: Keywords: circulating tumor dna (ctdna); human papilloma virus; metastasis; oropharynx cancer; squamous cell carcinoma
تواريخ الأحداث: Date Created: 20240618 Latest Revision: 20240619
رمز التحديث: 20240620
مُعرف محوري في PubMed: PMC11181740
DOI: 10.7759/cureus.60547
PMID: 38887331
قاعدة البيانات: MEDLINE
الوصف
تدمد:2168-8184
DOI:10.7759/cureus.60547