دورية أكاديمية
أعرض في EDS

CD28-CD57+ T cells from head and neck cancer patients produce high levels of cytotoxic granules and type II interferon but are not senescent.

التفاصيل البيبلوغرافية
العنوان: CD28-CD57+ T cells from head and neck cancer patients produce high levels of cytotoxic granules and type II interferon but are not senescent.
المؤلفون: Kinney BLC; Department of Otolaryngology - Head and Neck Surgery, Emory University, Atlanta, GA, USA.; Winship Cancer Institute, Emory University, Atlanta, GA, USA., Brammer B; Department of Otolaryngology - Head and Neck Surgery, Emory University, Atlanta, GA, USA.; Winship Cancer Institute, Emory University, Atlanta, GA, USA., Kansal V; Department of Otolaryngology - Head and Neck Surgery, Emory University, Atlanta, GA, USA.; Winship Cancer Institute, Emory University, Atlanta, GA, USA., Parrish CJ; School of Medicine, St. Louis University School of Medicine, St. Louis, MO, USA., Kissick HT; Winship Cancer Institute, Emory University, Atlanta, GA, USA.; Department of Urology, Emory University, Atlanta, GA, USA.; Department of Microbiology and Immunology, Emory University, Atlanta, GA, USA., Liu Y; Winship Cancer Institute, Emory University, Atlanta, GA, USA.; Department of Biostatistics and Bioinformatics, Emory University, Atlanta, GA, USA., Saba NF; Winship Cancer Institute, Emory University, Atlanta, GA, USA.; Department of Hematology and Medical Oncology, Emory University, Atlanta, GA, USA., Buchwald ZS; Department of Radiation Oncology, Emory University, Atlanta, GA, USA., El-Deiry MW; Department of Otolaryngology - Head and Neck Surgery, Emory University, Atlanta, GA, USA.; Winship Cancer Institute, Emory University, Atlanta, GA, USA., Patel MR; Department of Otolaryngology - Head and Neck Surgery, Emory University, Atlanta, GA, USA.; Winship Cancer Institute, Emory University, Atlanta, GA, USA., Boyce BJ; Department of Otolaryngology - Head and Neck Surgery, Emory University, Atlanta, GA, USA.; Winship Cancer Institute, Emory University, Atlanta, GA, USA., Kaka AS; Department of Otolaryngology - Head and Neck Surgery, Emory University, Atlanta, GA, USA.; Winship Cancer Institute, Emory University, Atlanta, GA, USA., Gross JH; Department of Otolaryngology - Head and Neck Surgery, Emory University, Atlanta, GA, USA.; Winship Cancer Institute, Emory University, Atlanta, GA, USA., Baddour HM; Department of Otolaryngology - Head and Neck Surgery, Emory University, Atlanta, GA, USA.; Winship Cancer Institute, Emory University, Atlanta, GA, USA., Chen AY; Department of Otolaryngology - Head and Neck Surgery, Emory University, Atlanta, GA, USA.; Winship Cancer Institute, Emory University, Atlanta, GA, USA., Schmitt NC; Department of Otolaryngology - Head and Neck Surgery, Emory University, Atlanta, GA, USA.; Winship Cancer Institute, Emory University, Atlanta, GA, USA.
المصدر: Oncoimmunology [Oncoimmunology] 2024 Jun 14; Vol. 13 (1), pp. 2367777. Date of Electronic Publication: 2024 Jun 14 (Print Publication: 2024).
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Taylor & Francis Country of Publication: United States NLM ID: 101570526 Publication Model: eCollection Cited Medium: Internet ISSN: 2162-402X (Electronic) Linking ISSN: 21624011 NLM ISO Abbreviation: Oncoimmunology Subsets: MEDLINE
أسماء مطبوعة: Publication: 2015- : Philadelphia, PA : Taylor & Francis
Original Publication: Austin, TX : Landes Bioscience
مواضيع طبية MeSH: CD28 Antigens*/metabolism , CD57 Antigens*/metabolism , Head and Neck Neoplasms*/immunology , Head and Neck Neoplasms*/pathology , Head and Neck Neoplasms*/metabolism , CD8-Positive T-Lymphocytes*/immunology , CD8-Positive T-Lymphocytes*/metabolism , Cellular Senescence*/immunology, Humans ; Male ; Middle Aged ; Female ; Aged ; Interferon-gamma/metabolism ; Adult ; Cell Proliferation ; Aged, 80 and over
مستخلص: T lymphocytes expressing CD57 and lacking costimulatory receptors CD27/CD28 have been reported to accumulate with aging, chronic infection, and cancer. These cells are described as senescent, with inability to proliferate but enhanced cytolytic and cytokine-producing capacity. However, robust functional studies on these cells taken directly from cancer patients are lacking. We isolated these T cells and their CD27/28+ counterparts from blood and tumor samples of 50 patients with previously untreated head and neck cancer. Functional studies confirmed that these cells have enhanced ability to degranulate and produce IFN-γ. They also retain the ability to proliferate, thus are not senescent. These data suggest that CD27/28-CD57+ CD8+ T cells are a subset of highly differentiated, CD45RA+ effector memory (T EMRA ) cells with retained proliferative capacity. Patients with > 34% of these cells among CD8+ T cells in the blood had a higher rate of locoregional disease relapse, suggesting these cells may have prognostic significance.
Competing Interests: NCS discloses consulting fees from Sensorion, Regeneron, and GeoVax in addition to research funding from Astex Pharmaceuticals. The authors have no conflicting financial interests related to this work.
(© 2024 The Author(s). Published with license by Taylor & Francis Group, LLC.)
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فهرسة مساهمة: Keywords: CD28; CD57; KLRG1; TEMRA cells; cellular senescence; costimulation; head and neck cancer
المشرفين على المادة: 0 (CD28 Antigens)
0 (CD57 Antigens)
82115-62-6 (Interferon-gamma)
تواريخ الأحداث: Date Created: 20240618 Date Completed: 20240618 Latest Revision: 20240619
رمز التحديث: 20240619
مُعرف محوري في PubMed: PMC11181932
DOI: 10.1080/2162402X.2024.2367777
PMID: 38887372
قاعدة البيانات: MEDLINE
الوصف
تدمد:2162-402X
DOI:10.1080/2162402X.2024.2367777