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Systematic review: Patient-related, microbial, surgical, and histopathological risk factors for endoscopic post-operative recurrence in patients with Crohn's disease.

التفاصيل البيبلوغرافية
العنوان: Systematic review: Patient-related, microbial, surgical, and histopathological risk factors for endoscopic post-operative recurrence in patients with Crohn's disease.
المؤلفون: Bak MTJ; Department of Gastroenterology and Hepatology, Erasmus University Medical Center Rotterdam, Rotterdam, the Netherlands., Demers K; Research Institute for Nutrition and Translational Research in Metabolism (NUTRIM), Maastricht University, Maastricht, the Netherlands.; Department of Gastroenterology and Hepatology, Maastricht University Medical Center+, Maastricht, the Netherlands.; Department of Surgery, Maastricht University Medical Center+, Maastricht, the Netherlands., Hammoudi N; Gastroenterology Department, Hôpital Saint-Louis - APHP, Université Paris Cité, INSERM U1160, Paris, France., Allez M; Gastroenterology Department, Hôpital Saint-Louis - APHP, Université Paris Cité, INSERM U1160, Paris, France., Silverberg MS; Inflammatory Bowel Disease Centre, Mount Sinai Hospital, Toronto, Ontario, Canada., Fuhler GM; Department of Gastroenterology and Hepatology, Erasmus University Medical Center Rotterdam, Rotterdam, the Netherlands., Parikh K; Department of Gastroenterology and Hepatology, Erasmus University Medical Center Rotterdam, Rotterdam, the Netherlands., Pierik MJ; Research Institute for Nutrition and Translational Research in Metabolism (NUTRIM), Maastricht University, Maastricht, the Netherlands.; Department of Gastroenterology and Hepatology, Maastricht University Medical Center+, Maastricht, the Netherlands., Stassen LPS; Research Institute for Nutrition and Translational Research in Metabolism (NUTRIM), Maastricht University, Maastricht, the Netherlands.; Department of Surgery, Maastricht University Medical Center+, Maastricht, the Netherlands., van der Woude CJ; Department of Gastroenterology and Hepatology, Erasmus University Medical Center Rotterdam, Rotterdam, the Netherlands., Doukas M; Department of Pathology, Erasmus University Medical Center Rotterdam, Rotterdam, the Netherlands., van Ruler O; Department of Surgery, IJsselland Hospital, Capelle aan den IJssel, the Netherlands.; Department of Surgery, Erasmus University Medical Center Rotterdam, Rotterdam, the Netherlands., de Vries AC; Department of Gastroenterology and Hepatology, Erasmus University Medical Center Rotterdam, Rotterdam, the Netherlands.
المصدر: Alimentary pharmacology & therapeutics [Aliment Pharmacol Ther] 2024 Aug; Vol. 60 (3), pp. 310-326. Date of Electronic Publication: 2024 Jun 17.
نوع المنشور: Journal Article; Systematic Review; Review
اللغة: English
بيانات الدورية: Publisher: Wiley-Blackwell Country of Publication: England NLM ID: 8707234 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1365-2036 (Electronic) Linking ISSN: 02692813 NLM ISO Abbreviation: Aliment Pharmacol Ther Subsets: MEDLINE
أسماء مطبوعة: Publication: Oxford : Wiley-Blackwell
Original Publication: [Oxford, OX] : Blackwell Scientific Publications, [c1987-
مواضيع طبية MeSH: Crohn Disease*/surgery , Crohn Disease*/pathology , Recurrence*, Humans ; Risk Factors
مستخلص: Background: Risk stratification for endoscopic post-operative recurrence (ePOR) in Crohn's disease (CD) is required to identify patients who would benefit most from initiation of prophylactic medication and intensive monitoring of recurrence.
Aims: To assess the current evidence on patient-related, microbial, surgical and histopathological risk factors for ePOR in patients with CD after ileocolic (re-)resection.
Methods: Multiple online databases (Embase, MEDLINE, Web of Science and Cochrane Library) were searched up to March 2024. Studies with reported associations of patient-related, microbial, surgical and/or histopathological factors for ePOR (i.e., Rutgeerts' score ≥i2 or modified Rutgeerts' score ≥i2a) were included. The risk of bias was assessed with the Newcastle-Ottawa Scale for observational cohort studies and case-control studies.
Results: In total, 47 studies were included (four RCTs, 29 cohort studies, 12 case-control studies, one cross-sectional study and one individual participant data meta-analysis) including 6006 patients (median sample size 87 patients [interquartile range 46-170]). Risk of bias assessment revealed a poor quality in 41% of the studies. An association was reported in multiple studies of ePOR with active smoking at and post-surgery, male sex and prior bowel resection. A heterogeneous association with ePOR was reported for other risk factors included in the current guidelines (penetrating disease, perianal disease, younger age, extensive small bowel disease and presence of granulomas in the resection specimen or myenteric plexitis in the resection margin), and other patient-related, microbial, surgical and histopathological factors.
Conclusion: Risk factors for ePOR in international guidelines are not consistently reported as risk factors in current literature except for active smoking and prior bowel resection. To develop evidence-based, personalised strategies, large prospective studies are warranted to identify risk factors for ePOR. Validation studies of promising (bio)markers are also required.
(© 2024 The Authors. Alimentary Pharmacology & Therapeutics published by John Wiley & Sons Ltd.)
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تواريخ الأحداث: Date Created: 20240618 Date Completed: 20240710 Latest Revision: 20240712
رمز التحديث: 20240713
DOI: 10.1111/apt.18040
PMID: 38887827
قاعدة البيانات: MEDLINE
الوصف
تدمد:1365-2036
DOI:10.1111/apt.18040