دورية أكاديمية
Blood urea nitrogen to albumin ratio is a novel predictor of fatal outcome for patients with severe fever with thrombocytopenia syndrome.
| العنوان: | Blood urea nitrogen to albumin ratio is a novel predictor of fatal outcome for patients with severe fever with thrombocytopenia syndrome. |
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| المؤلفون: | Wang Y; Department of General Surgery, First Affiliated Hospital of Anhui Medical University, Hefei, Anhui Province, People's Republic of China., Qin LH; Department of Laboratory Medicine, Infection Hospital Area of the First Affiliated Hospital of University of Science and Technology of China (Hefei Infectious Disease Hospital), Hefei, Anhui Province, People's Republic of China.; Key Laboratory of Anhui Province for Emerging and Reemerging Infectious Diseases, Hefei, Anhui Province, People's Republic of China., Zhang K; Department of Clinical Laboratory, First Affiliated Hospital of Anhui Medical University, Hefei, Anhui Province, People's Republic of China., Zhang DW; Department of Respiratory and Critical Care Medicine, First Affiliated Hospital of Anhui Medical University, Hefei, Anhui Province, People's Republic of China., Wang WJ; Department of General Surgery, First Affiliated Hospital of Anhui Medical University, Hefei, Anhui Province, People's Republic of China., Xu AM; Department of General Surgery, First Affiliated Hospital of Anhui Medical University, Hefei, Anhui Province, People's Republic of China., Qi YJ; Department of Laboratory Medicine, Infection Hospital Area of the First Affiliated Hospital of University of Science and Technology of China (Hefei Infectious Disease Hospital), Hefei, Anhui Province, People's Republic of China.; Key Laboratory of Anhui Province for Emerging and Reemerging Infectious Diseases, Hefei, Anhui Province, People's Republic of China. |
| المصدر: | Journal of medical virology [J Med Virol] 2024 Jun; Vol. 96 (6), pp. e29731. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Wiley-Liss Country of Publication: United States NLM ID: 7705876 Publication Model: Print Cited Medium: Internet ISSN: 1096-9071 (Electronic) Linking ISSN: 01466615 NLM ISO Abbreviation: J Med Virol Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: New York Ny : Wiley-Liss Original Publication: New York, Liss. |
| مواضيع طبية MeSH: | Severe Fever with Thrombocytopenia Syndrome*/mortality , Severe Fever with Thrombocytopenia Syndrome*/blood , Severe Fever with Thrombocytopenia Syndrome*/diagnosis , Severe Fever with Thrombocytopenia Syndrome*/virology , Blood Urea Nitrogen*, Humans ; Female ; Male ; Middle Aged ; Aged ; Prognosis ; Biomarkers/blood ; Retrospective Studies ; Adult ; Aged, 80 and over |
| مستخلص: | Severe fever with thrombocytopenia syndrome (SFTS) is associated with a high death rate and lacks a targeted therapy plan. The ratio of blood urea nitrogen to albumin, known as BAR, is a valuable method for assessing the outlook of various infectious diseases. The objective of this research was to evaluate the effectiveness of BAR in forecasting the outcome of individuals with SFTS. Four hundred and thirty-seven patients with SFTS from two clinical centers were included in this study according to inclusion and exclusion criteria. Clinical characteristics and test parameters of SFTS patients were analyzed between survival and fatal groups. Least absolute shrinkage and selection operator (LASSO) regression and Cox regression suggested that BAR might serve as a standalone prognostic indicator for patients with SFTS in the initial phase (hazard ratio = 18.669, 95% confidence interval [CI]: 8.558-40.725, p < 0.001). And BAR had a better predictive effectiveness in clinical outcomes in patients with SFTS with an AUC of 0.832 (95% CI: 0.788-0.876, p < 0.001), a cutoff value of 0.19, a sensitivity of 0.812, and a specificity of 0.726 compared to C-reactive protein, procalcitonin, and platelet to lymphocyte ratio via receiver operating characteristic curve. KM (Kaplan Meier) curves demonstrated that high level of BAR was associated with poor survival condition in patients with SFTS. Furthermore, the high level of BAR was associated with long hospital stays and test paraments of kidney, liver, and coagulation function in survival patients. So, BAR could be used as a promising early warning biomarker of adverse outcomes in patients with SFTS. (© 2024 Wiley Periodicals LLC.) |
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| معلومات مُعتمدة: | The seventh cycle clinical key (cultivation) specialty in Hefei Department Construction Project (Clinical Laboratory) (Z033-1); Clinical Medicine Discipline Construction Project of Anhui Medical University |
| فهرسة مساهمة: | Keywords: BAR; SFTS; albumin; biomarker; blood urea nitrogen |
| المشرفين على المادة: | 0 (Biomarkers) |
| تواريخ الأحداث: | Date Created: 20240618 Date Completed: 20240618 Latest Revision: 20240618 |
| رمز التحديث: | 20240619 |
| DOI: | 10.1002/jmv.29731 |
| PMID: | 38888065 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1096-9071 |
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| DOI: | 10.1002/jmv.29731 |