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Succinate coenzyme A ligase β-like protein from Trichinella spiralis is a potential therapeutic molecule for allergic asthma.

التفاصيل البيبلوغرافية
العنوان: Succinate coenzyme A ligase β-like protein from Trichinella spiralis is a potential therapeutic molecule for allergic asthma.
المؤلفون: Aimulajiang K; Laboratory of Animal Health and Food Safety, MOE Joint International Research, College of Veterinary Medicine, Nanjing Agricultural University, Nanjing, Jiangsu, P. R. China.; State Key Laboratory of Pathogenesis, Prevention and Treatment of High Incidence Diseases in Central Asia, Clinical Medicine Institute, The First Affiliated Hospital of Xinjiang Medical University, Urumqi, Xinjiang, P. R. China., Chu W; Laboratory of Animal Health and Food Safety, MOE Joint International Research, College of Veterinary Medicine, Nanjing Agricultural University, Nanjing, Jiangsu, P. R. China., Liao S; Laboratory of Animal Health and Food Safety, MOE Joint International Research, College of Veterinary Medicine, Nanjing Agricultural University, Nanjing, Jiangsu, P. R. China.; Changsha Animal and Plant Disease Control Center, Changsha, Hunan, P. R. China., Wen Z; Laboratory of Animal Health and Food Safety, MOE Joint International Research, College of Veterinary Medicine, Nanjing Agricultural University, Nanjing, Jiangsu, P. R. China.; Department of Veterinary Medicine, College of Coastal Agricultural Sciences, Guangdong Ocean University, Zhanjiang, P. R. China., He R; State Key Laboratory of Pathogenesis, Prevention and Treatment of High Incidence Diseases in Central Asia, Clinical Medicine Institute, The First Affiliated Hospital of Xinjiang Medical University, Urumqi, Xinjiang, P. R. China., Lu M; Laboratory of Animal Health and Food Safety, MOE Joint International Research, College of Veterinary Medicine, Nanjing Agricultural University, Nanjing, Jiangsu, P. R. China., Xu L; Laboratory of Animal Health and Food Safety, MOE Joint International Research, College of Veterinary Medicine, Nanjing Agricultural University, Nanjing, Jiangsu, P. R. China., Song X; Laboratory of Animal Health and Food Safety, MOE Joint International Research, College of Veterinary Medicine, Nanjing Agricultural University, Nanjing, Jiangsu, P. R. China., Li X; Laboratory of Animal Health and Food Safety, MOE Joint International Research, College of Veterinary Medicine, Nanjing Agricultural University, Nanjing, Jiangsu, P. R. China., Yan R; Laboratory of Animal Health and Food Safety, MOE Joint International Research, College of Veterinary Medicine, Nanjing Agricultural University, Nanjing, Jiangsu, P. R. China.
المصدر: Immunity, inflammation and disease [Immun Inflamm Dis] 2024 Jun; Vol. 12 (6), pp. e1321.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: John Wiley and Sons Ltd Country of Publication: England NLM ID: 101635460 Publication Model: Print Cited Medium: Internet ISSN: 2050-4527 (Electronic) Linking ISSN: 20504527 NLM ISO Abbreviation: Immun Inflamm Dis Subsets: MEDLINE
أسماء مطبوعة: Original Publication: [Oxford] : John Wiley and Sons Ltd, [2013]-
مواضيع طبية MeSH: Trichinella spiralis*/immunology , Asthma*/immunology , Asthma*/drug therapy , Ovalbumin*/immunology , Helminth Proteins*/immunology , Helminth Proteins*/pharmacology, Animals ; Mice ; Mice, Inbred BALB C ; Disease Models, Animal ; Female ; Cytokines/metabolism ; Cytokines/immunology ; Immunoglobulin E/immunology ; Lung/immunology ; Lung/parasitology ; Lung/pathology ; T-Lymphocytes, Regulatory/immunology ; Hypersensitivity/immunology ; Hypersensitivity/drug therapy ; Th17 Cells/immunology
مستخلص: Background: For decades, studies have demonstrated the anti-inflammatory potential of proteins secreted by helminths in allergies and asthma. Previous studies have demonstrated the immunomodulatory capabilities of Succinate Coenzyme A ligase beta-like protein (SUCLA-β) derived from Trichinella spiralis, a crucial excretory product of this parasite.
Objective: To explore the therapeutic potential of SUCLA-β in alleviating and controlling ovalbumin (OVA)-induced allergic asthma, as well as its influence on host immune modulation.
Methods: In this research, we utilized the rTs-SUCLA-β protein derived from T. spiralis to investigate its potential in mitigating airway inflammation in a murine model of asthma induced by OVA sensitization/stimulation, both pre- and post-challenge. The treatment's efficacy was assessed by quantifying the extent of inflammation in the lungs.
Results: Treatment with rTs-SUCLA-β demonstrated efficacy in ameliorating OVA-induced airway inflammation, as evidenced by a reduction in eosinophil infiltration, levels of OVA-specific Immunoglobulin E, interferon-γ, interleukin (IL)-9, and IL-17A, along with an elevation in IL-10. The equilibrium between Th17 and Treg cells plays a pivotal role in modulating the abundance of inflammatory cells within the organism, thereby ameliorating inflammation and alleviating symptoms associated with allergic asthma.
Conclusions and Clinical Relevance: Our data revealed that T. spiralis-derived Ts-SUCLA-β protein may inhibit the allergic airway inflammation by regulating host immune responses.
(© 2024 The Author(s). Immunity, Inflammation and Disease published by John Wiley & Sons Ltd.)
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معلومات مُعتمدة: SKL-HIDCA-2022-20 State Key Laboratory of Pathogenesis, Prevention and Treatment of High Incidence Diseases in Central Asia Fund; BE2022848 Social Development Project of Jiangsu Province
فهرسة مساهمة: Keywords: Succinate Coenzyme A ligase beta‐like protein; Trichinella spiralis; allergic asthma; helminth molecules; immune regulation
المشرفين على المادة: 9006-59-1 (Ovalbumin)
0 (Helminth Proteins)
0 (Cytokines)
37341-29-0 (Immunoglobulin E)
تواريخ الأحداث: Date Created: 20240618 Date Completed: 20240618 Latest Revision: 20240620
رمز التحديث: 20240620
مُعرف محوري في PubMed: PMC11184933
DOI: 10.1002/iid3.1321
PMID: 38888451
قاعدة البيانات: MEDLINE
الوصف
تدمد:2050-4527
DOI:10.1002/iid3.1321