دورية أكاديمية
Incentive-salience attribution is attenuated in spontaneously hypertensive rats, an animal model of ADHD.
| العنوان: | Incentive-salience attribution is attenuated in spontaneously hypertensive rats, an animal model of ADHD. |
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| المؤلفون: | González-Barriga F; Facultad de Psicología, Universidad Nacional Autónoma de México, Mexico City 04510, Mexico., Orduña V; Facultad de Psicología, Universidad Nacional Autónoma de México, Mexico City 04510, Mexico. Electronic address: vladord@unam.mx. |
| المصدر: | Behavioural processes [Behav Processes] 2024 Aug; Vol. 220, pp. 105068. Date of Electronic Publication: 2024 Jun 16. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Scientific Pub. Co Country of Publication: Netherlands NLM ID: 7703854 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1872-8308 (Electronic) Linking ISSN: 03766357 NLM ISO Abbreviation: Behav Processes Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Amsterdam, Elsevier Scientific Pub. Co. |
| مواضيع طبية MeSH: | Attention Deficit Disorder with Hyperactivity*/physiopathology , Attention Deficit Disorder with Hyperactivity*/psychology , Rats, Inbred SHR* , Motivation*/physiology , Disease Models, Animal* , Rats, Wistar*, Animals ; Rats ; Male ; Conditioning, Classical/physiology ; Reinforcement, Psychology |
| مستخلص: | Spontaneously Hypertensive Rats (SHR) have been extensively studied as an animal model of Attention Deficit Hyperactivity Disorder (ADHD) because they show some of the defining features of that disorder, like some forms of impulsivity and hyperactivity. However, other characteristics of the disorder, like a deficit in motivation, have been scarcely studied in the SHR strain. In the present report, we studied in 45 SHR and 45 Wistar rats as a comparison group, the capacity of attribution of incentive salience to a stimulus predictor of reinforcement, which has become a central concept in the study of motivation. We employed the Pavlovian Conditioned-Approach (PCA) task, in which a lever is presented 8 s before a pellet is delivered. The attribution of incentive salience is indicated by responses to the lever, in contrast to the absence of attribution of incentive salience, which is indicated by entrances to the pellet receptacle. For quantifying the attribution of incentive salience, we employed the PCA index, which integrates three related variables for each type of response, lever presses and entrances to the feeder: 1) the number of responses, 2) the latency to the first response, and 3) the probability that at least one response occurred during the presence of the lever. SHR showed lower levels of PCA, suggesting a deficit in the attribution of incentive salience to the lever. This finding replicates the results reported by previous research that compared SHR's performance in the PCA task against that of Sprague-Dawley rats. (Copyright © 2024 The Authors. Published by Elsevier B.V. All rights reserved.) |
| فهرسة مساهمة: | Keywords: ADHD; Incentive-salience; Motivation; Pavlovian Conditioned Approach; SHR |
| تواريخ الأحداث: | Date Created: 20240618 Date Completed: 20240805 Latest Revision: 20240805 |
| رمز التحديث: | 20240806 |
| DOI: | 10.1016/j.beproc.2024.105068 |
| PMID: | 38889852 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1872-8308 |
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| DOI: | 10.1016/j.beproc.2024.105068 |