دورية أكاديمية
أعرض في EDS

The Significant Role of PA28αβ in CD8 + T Cell-Mediated Graft Rejection Contrasts with Its Negligible Impact on the Generation of MHC-I Ligands.

التفاصيل البيبلوغرافية
العنوان: The Significant Role of PA28αβ in CD8 + T Cell-Mediated Graft Rejection Contrasts with Its Negligible Impact on the Generation of MHC-I Ligands.
المؤلفون: Inholz K; Biotechnology Institute Thurgau (BITg) at the University of Konstanz, 8280 Kreuzlingen, Switzerland.; Division of Immunology, Department of Biology, University of Konstanz, 78464 Konstanz, Germany., Bader U; Division of Immunology, Department of Biology, University of Konstanz, 78464 Konstanz, Germany., Mundt S; Institute of Experimental Immunology, University of Zurich, 8057 Zurich, Switzerland., Basler M; Biotechnology Institute Thurgau (BITg) at the University of Konstanz, 8280 Kreuzlingen, Switzerland.; Division of Immunology, Department of Biology, University of Konstanz, 78464 Konstanz, Germany.
المصدر: International journal of molecular sciences [Int J Mol Sci] 2024 May 22; Vol. 25 (11). Date of Electronic Publication: 2024 May 22.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067 (Electronic) Linking ISSN: 14220067 NLM ISO Abbreviation: Int J Mol Sci Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Basel, Switzerland : MDPI, [2000-
مواضيع طبية MeSH: Graft Rejection*/immunology , CD8-Positive T-Lymphocytes*/immunology , CD8-Positive T-Lymphocytes*/metabolism , Histocompatibility Antigens Class I*/metabolism , Histocompatibility Antigens Class I*/immunology , Mice, Knockout*, Animals ; Mice ; Proteasome Endopeptidase Complex/metabolism ; Proteasome Endopeptidase Complex/immunology ; Ligands ; Mice, Inbred C57BL ; Lymphocytic choriomeningitis virus/immunology ; Vaccinia virus/immunology
مستخلص: The proteasome generates the majority of peptides presented on MHC class I molecules. The cleavage pattern of the proteasome has been shown to be changed via the proteasome activator (PA)28 alpha beta (PA28αβ). In particular, several immunogenic peptides have been reported to be PA28αβ-dependent. In contrast, we did not observe a major impact of PA28αβ on the generation of different major histocompatibility complex (MHC) classI ligands. PA28αβ-knockout mice infected with the lymphocytic choriomeningitis virus ( LCMV ) or vaccinia virus showed a normal cluster of differentiation (CD) 8 response and viral clearance. However, we observed that the adoptive transfer of wild-type cells into PA28αβ-knockout mice led to graft rejection, but not vice versa. Depletion experiments showed that the observed rejection was mediated by CD8 + cytotoxic T cells. These data indicate that PA28αβ might be involved in the development of the CD8 + T cell repertoire in the thymus. Taken together, our data suggest that PA28αβ is a crucial factor determining T cell selection and, therefore, impacts graft acceptance.
References: Front Immunol. 2022 Jan 12;12:778559. (PMID: 35095851)
Nat Immunol. 2018 Sep;19(9):923-931. (PMID: 30104634)
Structure. 2017 Oct 3;25(10):1473-1480.e3. (PMID: 28867616)
Cell. 1996 Jul 26;86(2):253-62. (PMID: 8706130)
Mol Biol Cell. 2006 Dec;17(12):4962-71. (PMID: 16987959)
J Exp Med. 2001 Jun 4;193(11):1319-26. (PMID: 11390439)
Mol Immunol. 2000 Jan-Feb;37(1-2):13-9. (PMID: 10781831)
Cardiovasc Res. 2023 May 2;119(4):1030-1045. (PMID: 36464772)
Immunogenetics. 2019 Mar;71(3):251-261. (PMID: 30675634)
Nat Immunol. 2004 Jul;5(7):670-7. (PMID: 15224092)
Mol Immunol. 2019 Sep;113:22-30. (PMID: 29208314)
Mol Immunol. 2017 Mar;83:147-153. (PMID: 28157553)
Eur J Immunol. 2000 Dec;30(12):3672-9. (PMID: 11169410)
Biomolecules. 2014 Jun 19;4(2):566-84. (PMID: 24970231)
J Immunol. 2000 Jul 15;165(2):768-78. (PMID: 10878350)
J Biol Chem. 1995 Oct 6;270(40):23808-15. (PMID: 7559557)
J Exp Med. 2002 Jul 15;196(2):185-96. (PMID: 12119343)
Eur J Immunol. 2011 Apr;41(4):926-35. (PMID: 21360704)
Immunol Rev. 2005 Oct;207:19-30. (PMID: 16181324)
J Clin Invest. 2021 Nov 1;131(21):. (PMID: 34428180)
J Biol Chem. 2019 May 10;294(19):7740-7754. (PMID: 30914481)
Curr Opin Immunol. 2023 Aug;83:102336. (PMID: 37210932)
Front Microbiol. 2015 Jan 29;6:21. (PMID: 25688236)
Cells. 2022 May 07;11(9):. (PMID: 35563886)
Eur J Immunol. 1989 Sep;19(9):1657-67. (PMID: 2477254)
J Immunol. 2009 Nov 15;183(10):6145-50. (PMID: 19841190)
J Immunol. 2015 Nov 1;195(9):4106-16. (PMID: 26401002)
Nephrol Dial Transplant. 2010 Nov;25(11):3764-73. (PMID: 20466656)
J Exp Med. 2001 Jul 2;194(1):1-12. (PMID: 11435468)
J Immunol. 2012 Aug 15;189(4):1868-77. (PMID: 22772448)
Proc Natl Acad Sci U S A. 2006 Mar 28;103(13):5042-7. (PMID: 16549793)
Arch Immunol Ther Exp (Warsz). 2013 Oct;61(5):397-405. (PMID: 23685832)
Mol Immunol. 2017 Aug;88:32-37. (PMID: 28582644)
Proc Natl Acad Sci U S A. 1992 Jul 1;89(13):6020-4. (PMID: 1378619)
Eur J Immunol. 2004 Oct;34(10):2681-9. (PMID: 15368284)
Immunogenetics. 2019 Mar;71(3):263-271. (PMID: 30220008)
Methods Enzymol. 2005;398:336-52. (PMID: 16275341)
PLoS One. 2017 Mar 9;12(3):e0173259. (PMID: 28278207)
Nature. 1996 May 9;381(6578):166-8. (PMID: 8610016)
Chem Biol. 2014 Apr 24;21(4):470-480. (PMID: 24631123)
EMBO J. 2001 Nov 1;20(21):5898-907. (PMID: 11689430)
Eur J Immunol. 2018 Mar;48(3):419-429. (PMID: 29067678)
EMBO J. 2002 Jun 3;21(11):2636-45. (PMID: 12032076)
Biomolecules. 2022 Mar 13;12(3):. (PMID: 35327634)
Mol Cell Proteomics. 2013 Mar;12(3):687-99. (PMID: 23242550)
Mol Immunol. 2002 Oct;39(3-4):165-9. (PMID: 12200048)
J Immunol. 2006 Jun 1;176(11):6665-72. (PMID: 16709825)
J Biol Chem. 2000 May 12;275(19):14336-45. (PMID: 10799514)
Peptides. 2021 Dec;146:170671. (PMID: 34624431)
Eur J Immunol. 2024 Apr;54(4):e2350613. (PMID: 38458995)
معلومات مُعتمدة: GR 1517/25-1 Deutsche Forschungsgemeinschaft; Forschungspreis Walter Enggist
فهرسة مساهمة: Keywords: CD8 T cell response; PA28αβ; adoptive cell transfer; antigen presentation; antigen processing; proteasome; rejection
المشرفين على المادة: 0 (Histocompatibility Antigens Class I)
EC 3.4.25.1 (Proteasome Endopeptidase Complex)
0 (Ligands)
تواريخ الأحداث: Date Created: 20240619 Date Completed: 20240619 Latest Revision: 20240703
رمز التحديث: 20240703
مُعرف محوري في PubMed: PMC11172216
DOI: 10.3390/ijms25115649
PMID: 38891837
قاعدة البيانات: MEDLINE
الوصف
تدمد:1422-0067
DOI:10.3390/ijms25115649