دورية أكاديمية
أعرض في EDS

Exploring the Pathogenesis of Spondylarthritis beyond HLA-B27: A Descriptive Review.

التفاصيل البيبلوغرافية
العنوان: Exploring the Pathogenesis of Spondylarthritis beyond HLA-B27: A Descriptive Review.
المؤلفون: Nagit RE; Immunology Department, 'Grigore T. Popa' University of Medicine and Pharmacy, 700115 Iași, Romania., Rezus E; Rheumatology Department, 'Grigore T. Popa' University of Medicine and Pharmacy, 700115 Iași, Romania.; Clinical Rehabilitation Hospital, 700661 Iași, Romania., Cianga P; Immunology Department, 'Grigore T. Popa' University of Medicine and Pharmacy, 700115 Iași, Romania.; Immunology Laboratory, 'St. Spiridon' Clinical Hospital, 700111 Iași, Romania.
المصدر: International journal of molecular sciences [Int J Mol Sci] 2024 May 31; Vol. 25 (11). Date of Electronic Publication: 2024 May 31.
نوع المنشور: Journal Article; Review
اللغة: English
بيانات الدورية: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067 (Electronic) Linking ISSN: 14220067 NLM ISO Abbreviation: Int J Mol Sci Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Basel, Switzerland : MDPI, [2000-
مواضيع طبية MeSH: HLA-B27 Antigen*/genetics , Spondylarthritis*/genetics , Spondylarthritis*/immunology , Spondylarthritis*/etiology , Genetic Predisposition to Disease*, Humans ; Genome-Wide Association Study ; Spondylitis, Ankylosing/genetics ; Spondylitis, Ankylosing/immunology ; Microbiota
مستخلص: Spondylarthritis (SpA) is a chronic inflammatory condition that encompasses damage to the axial or peripheral skeleton, accompanied by specific extra-articular symptoms. Within this group, Ankylosing Spondylitis stands out as the hallmark member. Although the heritability of Ankylosing Spondylitis is estimated to be over 95%, only a portion of the heritability has been explained, with HLA-B27 accounting for 20.1% of it; therefore, ongoing research endeavors are currently concentrated on investigating the potential participation of different entities in the development of the disease. Genome-wide association studies have led to significant advances in our understanding of the genetics of SpA. In this descriptive review, we delve into the pathogenesis of Spondylarthritis beyond HLA-B27. We summarize the latest research on the potential participation of various entities in the development of the disease, including other genetic loci, immune dysregulation, microbiota, and environmental factors. The multifactorial nature of SpA and the complex interplay of genetic, immunological, and environmental factors are being increasingly recognized; therefore, it is of paramount importance to consider a holistic approach to comprehend the pathogenesis of SpA in order to identify novel therapeutic targets.
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فهرسة مساهمة: Keywords: HLA-B27; heritability; microbiota; pathogenesis; spondylarthritis
المشرفين على المادة: 0 (HLA-B27 Antigen)
تواريخ الأحداث: Date Created: 20240619 Date Completed: 20240619 Latest Revision: 20240620
رمز التحديث: 20240620
مُعرف محوري في PubMed: PMC11172491
DOI: 10.3390/ijms25116081
PMID: 38892265
قاعدة البيانات: MEDLINE
الوصف
تدمد:1422-0067
DOI:10.3390/ijms25116081