دورية أكاديمية
أعرض في EDS

SCGB1C1 Plays a Critical Role in Suppression of Allergic Airway Inflammation through the Induction of Regulatory T Cell Expansion.

التفاصيل البيبلوغرافية
العنوان: SCGB1C1 Plays a Critical Role in Suppression of Allergic Airway Inflammation through the Induction of Regulatory T Cell Expansion.
المؤلفون: Kim SD; Department of Otorhinolaryngology, Pusan National University Hospital, Busan 49241, Republic of Korea., Kang SA; Department of Parasitology and Tropical Medicine, Pusan National University School of Medicine, Yangsan 50612, Republic of Korea., Mun SJ; Department of Otorhinolaryngology, Pusan National University Yangsan Hospital, Yangsan 50612, Republic of Korea., Yu HS; Department of Parasitology and Tropical Medicine, Pusan National University School of Medicine, Yangsan 50612, Republic of Korea., Roh HJ; Department of Otorhinolaryngology, Pusan National University Yangsan Hospital, Yangsan 50612, Republic of Korea., Cho KS; Department of Otorhinolaryngology, Pusan National University Hospital, Busan 49241, Republic of Korea.
المصدر: International journal of molecular sciences [Int J Mol Sci] 2024 Jun 06; Vol. 25 (11). Date of Electronic Publication: 2024 Jun 06.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067 (Electronic) Linking ISSN: 14220067 NLM ISO Abbreviation: Int J Mol Sci Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Basel, Switzerland : MDPI, [2000-
مواضيع طبية MeSH: T-Lymphocytes, Regulatory*/immunology , Asthma*/immunology , Asthma*/metabolism , Mice, Inbred C57BL* , Ovalbumin*, Animals ; Mice ; Lung/pathology ; Lung/immunology ; Lung/metabolism ; Bronchoalveolar Lavage Fluid ; Cytokines/metabolism ; Disease Models, Animal ; Immunoglobulin E/blood ; Immunoglobulin E/immunology ; Female ; Inflammation/immunology ; Inflammation/metabolism ; Inflammation/pathology ; Eosinophils/immunology ; Eosinophils/metabolism
مستخلص: The nanosized vesicles secreted from various cell types into the surrounding extracellular space are called extracellular vesicles (EVs). Although mesenchymal stem cell-derived EVs are known to have immunomodulatory effects in asthmatic mice, the role of identified pulmonary genes in the suppression of allergic airway inflammation remains to be elucidated. Moreover, the major genes responsible for immune regulation in allergic airway diseases have not been well documented. This study aims to evaluate the immunomodulatory effects of secretoglobin family 1C member 1 (SCGB1C1) on asthmatic mouse models. C57BL/6 mice were sensitized to ovalbumin (OVA) using intraperitoneal injection and were intranasally challenged with OVA. To evaluate the effect of SCGB1C1 on allergic airway inflammation, 5 μg/50 μL of SCGB1C1 was administrated intranasally before an OVA challenge. We evaluated airway hyperresponsiveness (AHR), total inflammatory cells, eosinophils in the bronchoalveolar lavage fluid (BALF), lung histology, serum immunoglobulin (Ig), the cytokine profiles of BALF and lung-draining lymph nodes (LLN), and the T cell populations in LLNs. The intranasal administration of SCGB1C1 significantly inhibited AHR, the presence of eosinophils in BALF, eosinophilic inflammation, goblet cell hyperplasia in the lung, and serum total and allergen-specific IgE. SCGB1C1 treatment significantly decreased the expression of interleukin (IL)-5 in the BALF and IL-4 in the LLN, but significantly increased the expression of IL-10 and transforming growth factor (TGF)-β in the BALF. Furthermore, SCGB1C1 treatment notably increased the populations of CD4 + CD25 + Foxp3 + regulatory T cells (Tregs) in asthmatic mice. The intranasal administration of SCGB1C1 provides a significant reduction in allergic airway inflammation and improvement of lung function through the induction of Treg expansion. Therefore, SCGB1C1 may be the major regulator responsible for suppressing allergic airway inflammation.
References: Clin Exp Allergy. 2010 Nov;40(11):1632-41. (PMID: 20553297)
J Neurosci Res. 2009 Aug 1;87(10):2264-72. (PMID: 19301423)
Cells. 2020 Mar 13;9(3):. (PMID: 32183102)
Stem Cells Int. 2020 Jun 27;2020:5684250. (PMID: 32676117)
Stem Cells. 2011 Jul;29(7):1137-48. (PMID: 21544902)
Stem Cell Res. 2019 Aug;39:101500. (PMID: 31344653)
Cells. 2019 Jul 15;8(7):. (PMID: 31311206)
Eur J Immunol. 2006 Oct;36(10):2566-73. (PMID: 17013987)
Am J Respir Cell Mol Biol. 2012 Feb;46(2):207-16. (PMID: 21903873)
Stem Cells Dev. 2010 Nov;19(11):1811-8. (PMID: 20225940)
Mediators Inflamm. 2014;2014:436476. (PMID: 25246732)
Stem Cell Res Ther. 2017 Jan 23;8(1):8. (PMID: 28114970)
Am J Physiol Lung Cell Mol Physiol. 2010 Dec;299(6):L760-70. (PMID: 20817776)
Stem Cells Transl Med. 2015 Nov;4(11):1302-16. (PMID: 26378259)
Biol Sport. 2016 Jun;33(2):107-10. (PMID: 27274102)
Life (Basel). 2022 Nov 29;12(12):. (PMID: 36556359)
PLoS One. 2015 Jul 15;10(7):e0131813. (PMID: 26176545)
Hum Genomics. 2011 Oct;5(6):691-702. (PMID: 22155607)
Cell Mol Biol (Noisy-le-grand). 2018 Jan 31;64(1):97-102. (PMID: 29412801)
Allergy. 2005 Aug;60(8):986-95. (PMID: 15969678)
Anat Cell Biol. 2013 Dec;46(4):262-71. (PMID: 24386599)
J Exp Med. 2005 Nov 7;202(9):1199-212. (PMID: 16275759)
Allergy Asthma Immunol Res. 2017 Jan;9(1):25-34. (PMID: 27826959)
Allergy Asthma Immunol Res. 2019 Mar;11(2):156-169. (PMID: 30661309)
Endocr Regul. 1999 Jun;33(2):90-4. (PMID: 10467430)
BMC Res Notes. 2012 Nov 13;5:630. (PMID: 23148572)
Exp Cell Res. 2018 Feb 1;363(1):114-120. (PMID: 29277503)
Nat Cell Biol. 2007 Jun;9(6):654-9. (PMID: 17486113)
Expert Opin Biol Ther. 2016;16(4):489-506. (PMID: 26817494)
J Immunol. 2004 Mar 15;172(6):3842-9. (PMID: 15004191)
Stem Cells Int. 2021 Jul 31;2021:6686625. (PMID: 34899920)
Nat Med. 2007 May;13(5):570-8. (PMID: 17435770)
PLoS One. 2013 Oct 24;8(10):e76520. (PMID: 24204633)
فهرسة مساهمة: Keywords: adipose stem cells; extracellular vesicles; immunosuppression; mesenchymal stromal cells; secretoglobin family 1C member 1
المشرفين على المادة: 9006-59-1 (Ovalbumin)
0 (Cytokines)
37341-29-0 (Immunoglobulin E)
تواريخ الأحداث: Date Created: 20240619 Date Completed: 20240619 Latest Revision: 20240708
رمز التحديث: 20240708
مُعرف محوري في PubMed: PMC11173076
DOI: 10.3390/ijms25116282
PMID: 38892470
قاعدة البيانات: MEDLINE
الوصف
تدمد:1422-0067
DOI:10.3390/ijms25116282