دورية أكاديمية
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Atractylodes macrocephala Koidz Alleviates Symptoms in Zymosan-Induced Irritable Bowel Syndrome Mouse Model through TRPV1, NaV1.5, and NaV1.7 Channel Modulation.

التفاصيل البيبلوغرافية
العنوان: Atractylodes macrocephala Koidz Alleviates Symptoms in Zymosan-Induced Irritable Bowel Syndrome Mouse Model through TRPV1, NaV1.5, and NaV1.7 Channel Modulation.
المؤلفون: Choi NR; Department of Longevity and Biofunctional Medicine, School of Korean Medicine, Pusan National University, Yangsan 50612, Republic of Korea.; Department of Korean Medical Science, School of Korean Medicine, Pusan National University, Yangsan 50612, Republic of Korea., Choi WG; Department of Longevity and Biofunctional Medicine, School of Korean Medicine, Pusan National University, Yangsan 50612, Republic of Korea., Lee JH; Department of Biomedical Engineering, College of Engineering, Dong-Eui University, Busan 47340, Republic of Korea., Park J; Division of Food Functionality, Korea Food Research Institute, Wanju-gun 55365, Republic of Korea.; Department of Food Biotechnology, Korea University of Science & Technology, Daejeon 34113, Republic of Korea., Kim YT; Division of Food Functionality, Korea Food Research Institute, Wanju-gun 55365, Republic of Korea.; Department of Food Biotechnology, Korea University of Science & Technology, Daejeon 34113, Republic of Korea., Das R; Department of Physiology, College of Medicine, Dongguk University, Gyeongju 38066, Republic of Korea., Woo JH; Department of Physiology, College of Medicine, Dongguk University, Gyeongju 38066, Republic of Korea., Kim BJ; Department of Longevity and Biofunctional Medicine, School of Korean Medicine, Pusan National University, Yangsan 50612, Republic of Korea.
المصدر: Nutrients [Nutrients] 2024 May 29; Vol. 16 (11). Date of Electronic Publication: 2024 May 29.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: MDPI Publishing Country of Publication: Switzerland NLM ID: 101521595 Publication Model: Electronic Cited Medium: Internet ISSN: 2072-6643 (Electronic) Linking ISSN: 20726643 NLM ISO Abbreviation: Nutrients Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Basel, Switzerland : MDPI Publishing
مواضيع طبية MeSH: Irritable Bowel Syndrome*/drug therapy , Irritable Bowel Syndrome*/chemically induced , TRPV Cation Channels*/metabolism , Disease Models, Animal* , Zymosan* , Atractylodes*/chemistry, Animals ; Mice ; Male ; Plant Extracts/pharmacology ; NAV1.7 Voltage-Gated Sodium Channel/metabolism ; Colon/drug effects ; Colon/metabolism ; Colon/pathology ; Intestinal Mucosa/metabolism ; Intestinal Mucosa/drug effects
مستخلص: (1) Background: Irritable bowel syndrome (IBS) is a common disease in the gastrointestinal (GI) tract. Atractylodes macrocephala Koidz (AMK) is known as one of the traditional medicines that shows a good efficacy in the GI tract. (2) Methods: We investigated the effect of AMK in a network pharmacology and zymosan-induced IBS animal model. In addition, we performed electrophysiological experiments to confirm the regulatory mechanisms related to IBS. (3) Results: Various characteristics of AMK were investigated using TCMSP data and various analysis systems. AMK restored the macroscopic changes and weight to normal. Colonic mucosa and inflammatory factors were reduced. These effects were similar to those of amitriptyline and sulfasalazine. In addition, transient receptor potential (TRP) V1, voltage-gated Na + (NaV) 1.5, and NaV1.7 channels were inhibited. (4) Conclusion: These results suggest that AMK may be a promising therapeutic candidate for IBS management through the regulation of ion channels.
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معلومات مُعتمدة: HF22C0063 This research was supported by a grant of the Korea Health Technology R&D Project through the Korea Health Industry Development Institute (KHIDI), funded by the Ministry of Health & Welfare, Republic of Korea.
فهرسة مساهمة: Keywords: gastrointestinal disease; ion channel; quality of life; traditional medicine; visceral hypersensitivity
المشرفين على المادة: 0 (TRPV Cation Channels)
9010-72-4 (Zymosan)
0 (Plant Extracts)
0 (TRPV1 protein, mouse)
0 (NAV1.7 Voltage-Gated Sodium Channel)
تواريخ الأحداث: Date Created: 20240619 Date Completed: 20240619 Latest Revision: 20240708
رمز التحديث: 20240708
مُعرف محوري في PubMed: PMC11174792
DOI: 10.3390/nu16111683
PMID: 38892616
قاعدة البيانات: MEDLINE
الوصف
تدمد:2072-6643
DOI:10.3390/nu16111683