دورية أكاديمية
أعرض في EDS

Radiotherapy Plan Quality Assurance in NRG Oncology Trials for Brain and Head/Neck Cancers: An AI-Enhanced Knowledge-Based Approach.

التفاصيل البيبلوغرافية
العنوان: Radiotherapy Plan Quality Assurance in NRG Oncology Trials for Brain and Head/Neck Cancers: An AI-Enhanced Knowledge-Based Approach.
المؤلفون: Wang D; Department of Radiation Oncology, University of Pennsylvania, Philadelphia, PA 19104, USA., Geng H; Department of Radiation Oncology, University of Pennsylvania, Philadelphia, PA 19104, USA., Gondi V; Northwestern Medicine Cancer Center Warrenville, Warrenville, IL 60555, USA., Lee NY; Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA., Tsien CI; McGill University Health Centre, Montreal, QC H4A 3J1, Canada., Xia P; Cleveland Clinic Foundation, Cleveland, OH 44195, USA., Chenevert TL; Department of Radiology, University of Michigan, Ann Arbor, MI 48109, USA., Michalski JM; Department of Radiation Oncology, Washington University School of Medicine, St. Louis, MO 63110, USA., Gilbert MR; National Cancer Institute, Bethesda, MD 20892, USA., Le QT; Stanford Cancer Institute, Stanford, CA 94305, USA., Omuro AM; Stanford Cancer Institute, Stanford, CA 94305, USA., Men K; Department of Radiation Oncology, University of Pennsylvania, Philadelphia, PA 19104, USA., Aldape KD; National Cancer Institute, Bethesda, MD 20892, USA., Cao Y; Department of Radiology, University of Michigan, Ann Arbor, MI 48109, USA., Srinivasan A; Department of Radiology, University of Michigan, Ann Arbor, MI 48109, USA., Barani IJ; Saint Joseph's Hospital and Medical Center, Phoenix, AZ 85013, USA., Sachdev S; Northwestern Medicine Cancer Center Warrenville, Warrenville, IL 60555, USA., Huang J; Department of Radiation Oncology, Washington University School of Medicine, St. Louis, MO 63110, USA., Choi S; UPMC-Shadyside Hospital, Case Western Reserve University, Pittsburgh, PA 15232, USA., Shi W; Department of Radiation Oncology, Thomas Jefferson University Hospital, Philadelphia, PA 19107, USA., Battiste JD; Stephenson Cancer Center, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA., Wardak Z; UT Southwestern, Simmons Cancer Center, Dallas, TX 75235, USA., Chan MD; Baptist Comprehensive Cancer Center, Wake Forest University Health Sciences, Winston-Salem, NC 27157, USA., Mehta MP; Miami Cancer Institute, Miami, FL 33176, USA., Xiao Y; Department of Radiation Oncology, University of Pennsylvania, Philadelphia, PA 19104, USA.
المصدر: Cancers [Cancers (Basel)] 2024 May 25; Vol. 16 (11). Date of Electronic Publication: 2024 May 25.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101526829 Publication Model: Electronic Cited Medium: Print ISSN: 2072-6694 (Print) Linking ISSN: 20726694 NLM ISO Abbreviation: Cancers (Basel) Subsets: PubMed not MEDLINE
أسماء مطبوعة: Original Publication: Basel, Switzerland : MDPI
مستخلص: The quality of radiation therapy (RT) treatment plans directly affects the outcomes of clinical trials. KBP solutions have been utilized in RT plan quality assurance (QA). In this study, we evaluated the quality of RT plans for brain and head/neck cancers enrolled in multi-institutional clinical trials utilizing a KBP approach. The evaluation was conducted on 203 glioblastoma (GBM) patients enrolled in NRG-BN001 and 70 nasopharyngeal carcinoma (NPC) patients enrolled in NRG-HN001. For each trial, fifty high-quality photon plans were utilized to build a KBP photon model. A KBP proton model was generated using intensity-modulated proton therapy (IMPT) plans generated on 50 patients originally treated with photon RT. These models were then applied to generate KBP plans for the remaining patients, which were compared against the submitted plans for quality evaluation, including in terms of protocol compliance, target coverage, and organ-at-risk (OAR) doses. RT plans generated by the KBP models were demonstrated to have superior quality compared to the submitted plans. KBP IMPT plans can decrease the variation of proton plan quality and could possibly be used as a tool for developing improved plans in the future. Additionally, the KBP tool proved to be an effective instrument for RT plan QA in multi-center clinical trials.
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معلومات مُعتمدة: U10CA180868 NRG Oncology Network Group Operations Center; U24CA180803 Imaging and Radiation Oncology Core (IROC) Group
فهرسة مساهمة: Keywords: brain and head/neck cancers; clinical trial quality assurance; knowledge-based planning; radiotherapy
تواريخ الأحداث: Date Created: 20240619 Latest Revision: 20240620
رمز التحديث: 20240620
مُعرف محوري في PubMed: PMC11171017
DOI: 10.3390/cancers16112007
PMID: 38893130
قاعدة البيانات: MEDLINE
الوصف
تدمد:2072-6694
DOI:10.3390/cancers16112007