التفاصيل البيبلوغرافية
| العنوان: |
Mixed representations of choice and outcome by GABA/glutamate cotransmitting neurons in the entopeduncular nucleus. |
| المؤلفون: |
Locantore J, Liu Y, White J, Wallace JB, Beron CC, Sabatini BL, Wallace ML |
| المصدر: |
BioRxiv : the preprint server for biology [bioRxiv] 2024 Jun 08. Date of Electronic Publication: 2024 Jun 08. |
| نوع المنشور: |
Journal Article; Preprint |
| اللغة: |
English |
| بيانات الدورية: |
Country of Publication: United States NLM ID: 101680187 Publication Model: Electronic Cited Medium: Internet NLM ISO Abbreviation: bioRxiv Subsets: PubMed not MEDLINE |
| مستخلص: |
The basal ganglia (BG) are an evolutionarily conserved and phylogenetically old set of sub-cortical nuclei that guide action selection, evaluation, and reinforcement. The entopeduncular nucleus (EP) is a major BG output nucleus that contains a population of GABA/glutamate cotransmitting neurons (EP Sst+ ) that specifically target the lateral habenula (LHb) and whose function in behavior remains mysterious. Here we use a probabilistic switching task that requires an animal to maintain flexible relationships between action selection and evaluation to examine when and how GABA/glutamate cotransmitting neurons contribute to behavior. We find that EP Sst+ neurons are strongly engaged during this task and show bidirectional changes in activity during the choice and outcome periods of a trial. We then tested the effects of either permanently blocking cotransmission or modifying the GABA/glutamate ratio on behavior in well-trained animals. Neither manipulation produced detectable changes in behavior despite significant changes in synaptic transmission in the LHb, demonstrating that the outputs of these neurons are not required for on-going action-outcome updating in a probabilistic switching task. |
| تواريخ الأحداث: |
Date Created: 20240619 Latest Revision: 20240619 |
| رمز التحديث: |
20240619 |
| مُعرف محوري في PubMed: |
PMC11185773 |
| DOI: |
10.1101/2024.06.07.597980 |
| PMID: |
38895480 |
| قاعدة البيانات: |
MEDLINE |
