دورية أكاديمية
أعرض في EDS

Biotechnological approaches for the production of camptothecin.

التفاصيل البيبلوغرافية
العنوان: Biotechnological approaches for the production of camptothecin.
المؤلفون: Banadka A; Department of Life Sciences, CHRIST (Deemed to be University), Bangalore, 560 029, Karnataka, India., Narasimha SW; Department of Life Sciences, CHRIST (Deemed to be University), Bangalore, 560 029, Karnataka, India., Dandin VS; Department of Biology, JSS College, Dharwad, India., Naik PM; Department of Botany, Karnatak University, Dharwad, 580003, Karnataka, India., Vennapusa AR; Department of Agriculture and Natural Resources, Delaware State University, Dover, DE, 19901, USA. avennapusa@desu.edu., Melmaiee K; Department of Agriculture and Natural Resources, Delaware State University, Dover, DE, 19901, USA., Vemanna RS; Laboratory of Plant Functional Genomics, Regional Center for Biotechnology, Faridabad, 121001, Haryana, India., Al-Khayri JM; Department of Agricultural Biotechnology, College of Agriculture and Food Sciences, King Faisal University, Al- Ahsa, 31982, Saudi Arabia. jkhayri@kfu.edu.sa., Thiruvengadam M; Department of Crop Science, College of Sanghuh Life Science, Konkuk University, Seoul, South Korea., Nagella P; Department of Life Sciences, CHRIST (Deemed to be University), Bangalore, 560 029, Karnataka, India. praveen.n@christuniversity.in.
المصدر: Applied microbiology and biotechnology [Appl Microbiol Biotechnol] 2024 Jun 19; Vol. 108 (1), pp. 382. Date of Electronic Publication: 2024 Jun 19.
نوع المنشور: Journal Article; Review
اللغة: English
بيانات الدورية: Publisher: Springer International Country of Publication: Germany NLM ID: 8406612 Publication Model: Electronic Cited Medium: Internet ISSN: 1432-0614 (Electronic) Linking ISSN: 01757598 NLM ISO Abbreviation: Appl Microbiol Biotechnol Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Berlin ; New York : Springer International, c1984-
مواضيع طبية MeSH: Camptothecin*/biosynthesis , Biotechnology*/methods , Endophytes*/metabolism , Endophytes*/genetics , Camptotheca*/metabolism, Antineoplastic Agents, Phytogenic/biosynthesis ; Humans
مستخلص: Camptothecin (CPT), an indole alkaloid popular for its anticancer property, is considered the third most promising drug after taxol and famous alkaloids from Vinca for the treatment of cancer in humans. Camptothecin was first identified in Camptotheca acuminata followed by several other plant species and endophytic fungi. Increased harvesting driven by rising global demand is depleting the availability of elite plant genotypes, such as Camptotheca acuminata and Nothapodytes nimmoniana, crucial for producing alkaloids used in treating diseases like cancer. Conservation of these genotypes for the future is imperative. Therefore, research on different plant tissue culture techniques such as cell suspension culture, hairy roots, adventitious root culture, elicitation strategies, and endophytic fungi has been adopted for the production of CPT to meet the increasing demand without affecting the source plant's existence. Currently, another strategy to increase camptothecin yield by genetic manipulation is underway. The present review discusses the plants and endophytes that are employed for camptothecin production and throws light on the plant tissue culture techniques for the regeneration of plants, callus culture, and selection of cell lines for the highest camptothecin production. The review further explains the simple, accurate, and cost-effective extraction and quantification methods. There is enormous potential for the sustainable production of CPT which could be met by culturing of suitable endophytes or plant cell or organ culture in a bioreactor scale production. Also, different gene editing tools provide opportunities for engineering the biosynthetic pathway of CPT, and the overall CPT production can be improved . KEY POINTS: • Camptothecin is a naturally occurring alkaloid with potent anticancer properties, primarily known for its ability to inhibit DNA topoisomerase I. • Plants and endophytes offer a potential approach for camptothecin production. • Biotechnology approaches like plant tissue culture techniques enhanced camptothecin production.
(© 2024. The Author(s).)
References: Adv Biochem Eng Biotechnol. 2008;111:187-228. (PMID: 18594786)
J Pharm Bioallied Sci. 2012 Jan;4(1):10-20. (PMID: 22368394)
Can J Microbiol. 2006 Mar;52(3):189-96. (PMID: 16604115)
J Chromatogr A. 2005 Jan 21;1063(1-2):9-13. (PMID: 15700452)
Drugs. 2002;62(14):2039-57. (PMID: 12269849)
Phytochemistry. 2003 Feb;62(3):461-70. (PMID: 12620359)
Int J Pharm Sci Res. 2015 Oct 1;6(10):4103-4112. (PMID: 26594645)
Asian Pac J Trop Biomed. 2012 May;2(5):389-93. (PMID: 23569936)
Biotechnol Adv. 2002 May;20(2):101-53. (PMID: 14538059)
Chin J Nat Med. 2020 Aug;18(8):582-593. (PMID: 32768165)
Planta Med. 2001 Mar;67(2):150-2. (PMID: 11301862)
Biotechnol Lett. 2004 Nov;26(22):1745-8. (PMID: 15604829)
Front Pharmacol. 2018 Apr 26;9:309. (PMID: 29755344)
Planta Med. 2011 May;77(7):759-64. (PMID: 21104605)
Pharmacognosy Res. 2016 Oct-Dec;8(4):238-243. (PMID: 27695261)
Plant Cell Rep. 1997 May;16(8):572-577. (PMID: 30727581)
J Nat Med. 2022 Sep;76(4):865-872. (PMID: 35788957)
Phytochemistry. 2010 Jan;71(1):117-22. (PMID: 19863979)
Planta. 2019 Apr;249(4):953-973. (PMID: 30715560)
Planta Med. 2002 Nov;68(11):1010-6. (PMID: 12451492)
Biotechnol Lett. 2011 Dec;33(12):2519-26. (PMID: 21826402)
Prikl Biokhim Mikrobiol. 2008 Mar-Apr;44(2):225-31. (PMID: 18669267)
Sci Rep. 2015 Feb 04;5:8227. (PMID: 25648209)
Phytochem Anal. 2013 Nov-Dec;24(6):623-30. (PMID: 23722924)
Prep Biochem Biotechnol. 2015;45(2):158-72. (PMID: 24840354)
J Nat Prod. 1979 Sep-Oct;42(5):475-7. (PMID: 521817)
Phytomedicine. 2013 Apr 15;20(6):521-7. (PMID: 23474217)
Planta Med. 1981 Dec;43(4):404-7. (PMID: 7330109)
Curr Pharm Des. 2008;14(11):1078-97. (PMID: 18473856)
Phytomedicine. 2013 Feb 15;20(3-4):337-42. (PMID: 23273751)
J Nat Prod. 1999 Oct;62(10):1427-9. (PMID: 10543908)
Bioorg Med Chem Lett. 2017 Feb 15;27(4):701-707. (PMID: 28073672)
Sci Rep. 2023 Sep 5;13(1):14614. (PMID: 37670002)
Nat Prod Res. 2011 Oct;25(18):1762-5. (PMID: 21899480)
Plant Cell. 2016 Aug;28(8):1926-44. (PMID: 27432874)
Appl Microbiol Biotechnol. 2013 Nov;97(21):9365-75. (PMID: 23949997)
Hortic Res. 2021 Jan 1;8(1):7. (PMID: 33384421)
Physiol Plant. 2023 May-Jun;175(3):e13916. (PMID: 37093159)
Nat Commun. 2021 Jun 10;12(1):3531. (PMID: 34112794)
Front Plant Sci. 2022 Mar 24;13:851077. (PMID: 35401649)
Braz J Microbiol. 2012 Oct;43(4):1476-90. (PMID: 24031979)
J Nat Prod. 2000 Sep;63(9):1273-6. (PMID: 11000035)
Eur J Nutr. 2005 Mar;44(2):85-94. (PMID: 15309426)
Fitoterapia. 2019 Apr;134:113-128. (PMID: 30794920)
J Nat Prod. 2009 Jan;72(1):2-7. (PMID: 19119919)
Am J Cancer Res. 2017 Dec 01;7(12):2350-2394. (PMID: 29312794)
J King Saud Univ Sci. 2021 Mar;33(2):101344. (PMID: 33531790)
Nat Prod Res. 2009;23(11):1050-7. (PMID: 19521920)
Pharmacognosy Res. 2010 Sep;2(5):296-9. (PMID: 21589755)
Oncology (Williston Park). 2001 Jan;15(1 Suppl 1):6-7. (PMID: 11221022)
J Integr Plant Biol. 2023 Jan;65(1):133-149. (PMID: 36194508)
Front Pharmacol. 2018 Mar 22;9:245. (PMID: 29623040)
Science. 2000 Jul 14;289(5477):295-7. (PMID: 10894776)
BMC Biol. 2021 Jun 16;19(1):122. (PMID: 34134716)
Hortic Res. 2022 Apr 22;9:uhac099. (PMID: 35795387)
Nat Prod Res. 2008;22(12):1017-23. (PMID: 18780241)
Sci Rep. 2021 Jan 14;11(1):1478. (PMID: 33446714)
Nat Prod Res. 2006 Jan;20(1):85-8. (PMID: 16286315)
Biotechnol Rep (Amst). 2020 Apr 20;26:e00450. (PMID: 32373483)
معلومات مُعتمدة: MRP-DSC-1414 Center for Research, CHRIST (Deemed to be Univeristy)
فهرسة مساهمة: Keywords: In vitro production; Nothapodytes Nimmoniana; Camptotheca acuminata; Camptothecin; Extraction; Quantification
المشرفين على المادة: XT3Z54Z28A (Camptothecin)
0 (Antineoplastic Agents, Phytogenic)
تواريخ الأحداث: Date Created: 20240619 Date Completed: 20240619 Latest Revision: 20240622
رمز التحديث: 20240622
مُعرف محوري في PubMed: PMC11186875
DOI: 10.1007/s00253-024-13187-2
PMID: 38896329
قاعدة البيانات: MEDLINE
الوصف
تدمد:1432-0614
DOI:10.1007/s00253-024-13187-2