دورية أكاديمية
ACE gene polymorphisms (rs4340) II and DI are more responsive to the ergogenic effect of caffeine than DD on aerobic power, heart rate, and perceived exertion in a homogeneous Brazilian group of adolescent athletes.
العنوان: | ACE gene polymorphisms (rs4340) II and DI are more responsive to the ergogenic effect of caffeine than DD on aerobic power, heart rate, and perceived exertion in a homogeneous Brazilian group of adolescent athletes. |
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المؤلفون: | Spineli H; Instituto de Educação Física e Esporte, Universidade Federal de Alagoas, Maceió, AL, Brasil., Santos MD; Instituto de Educação Física e Esporte, Universidade Federal de Alagoas, Maceió, AL, Brasil.; Instituto de Ciências Biológicas e da Saúde, Universidade Federal de Alagoas, Maceió, AL, Brasil., Almeida D; Instituto de Ciências Biológicas e da Saúde, Universidade Federal de Alagoas, Maceió, AL, Brasil., Gitaí D; Instituto de Ciências Biológicas e da Saúde, Universidade Federal de Alagoas, Maceió, AL, Brasil., Silva-Cavalcante M; Instituto Federal de Educação Ciência e Tecnologia de Alagoas, Maceió, AL, Brasil., Balikian P; Instituto de Educação Física e Esporte, Universidade Federal de Alagoas, Maceió, AL, Brasil., Ataide-Silva T; Faculdade de Nutrição, Universidade Federal de Alagoas, Maceió, AL, Brasil., Marinho A; Instituto de Educação Física e Esporte, Universidade Federal de Alagoas, Maceió, AL, Brasil., Sousa F; Instituto de Educação Física e Esporte, Universidade Federal de Alagoas, Maceió, AL, Brasil., Araujo G; Instituto de Educação Física e Esporte, Universidade Federal de Alagoas, Maceió, AL, Brasil.; Faculdade de Nutrição, Universidade Federal de Alagoas, Maceió, AL, Brasil. |
المصدر: | Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas [Braz J Med Biol Res] 2024 Jun 17; Vol. 57, pp. e13217. Date of Electronic Publication: 2024 Jun 17 (Print Publication: 2024). |
نوع المنشور: | Journal Article; Randomized Controlled Trial |
اللغة: | English |
بيانات الدورية: | Publisher: Associação Brasileira de Divulgação Científica Country of Publication: Brazil NLM ID: 8112917 Publication Model: eCollection Cited Medium: Internet ISSN: 1414-431X (Electronic) Linking ISSN: 0100879X NLM ISO Abbreviation: Braz J Med Biol Res Subsets: MEDLINE |
أسماء مطبوعة: | Original Publication: [SP, Brasil : Associação Brasileira de Divulgação Científica, 1981- |
مواضيع طبية MeSH: | Heart Rate*/drug effects , Caffeine*/administration & dosage , Genotype* , Athletes* , Physical Exertion*/physiology , Peptidyl-Dipeptidase A*/genetics, Humans ; Adolescent ; Male ; Athletic Performance/physiology ; Physical Endurance/drug effects ; Physical Endurance/genetics ; Polymorphism, Genetic/genetics ; Brazil ; Oxygen Consumption/genetics ; Oxygen Consumption/drug effects ; Performance-Enhancing Substances/administration & dosage |
مستخلص: | The purpose of this study was to verify the association between angiotensin-converting enzyme (ACE) genotypes DD, DI, and II and caffeine (CAF) ingestion on endurance performance, heart rate, ratio of perceived exertion (RPE), and habitual caffeine intake (HCI) of adolescent athletes. Seventy-four male adolescent athletes (age: DD=16±1.7; DI=16±2.0; II=15±1.7 years) ingested CAF (6 mg/kg) or placebo (PLA) one hour before performing the Yo-Yo Intermittent Recovery level 1 (Yo-Yo IR1) test. No difference was found among groups for HCI. However, CAF increased the maximal distance covered and VO2max in DI and II genotype carriers compared to PLA (DD: Δ=31 m and 0.3 mL·kg-1·min-1; DI: Δ=286 m and 1.1 mL·kg-1·min-1; II: Δ=160 m and 1.4 mL·kg-1·min-1). Heart rate of DI and II genotype carriers increased with CAF compared to PLA, while RPE was higher in the II and lower in the DD genotypes. The correlations between HCI and maximal distance covered or VO2max were significant in the II genotype carriers with CAF. CAF increased endurance capacity, heart rate, and RPE in adolescent athletes with allele I, while endurance performance and aerobic power had a positive correlation to HCI in the II genotype group. These findings suggested that DD genotype were less responsive to CAF and that genetic variations should be taken into account when using CAF supplementation to enhance exercise performance. |
References: | Scand J Med Sci Sports. 2005 Apr;15(2):69-78. (PMID: 15773860) Int J Sports Med. 2009 Jan;30(1):66-72. (PMID: 18651373) J Int Soc Sports Nutr. 2018 Mar 05;15:11. (PMID: 29527137) J Strength Cond Res. 2010 Jan;24(1):257-65. (PMID: 19924012) Sports Med. 2008;38(1):37-51. (PMID: 18081366) Br J Sports Med. 2020 Jun;54(11):681-688. (PMID: 30926628) J Appl Physiol (1985). 2018 Jun 1;124(6):1491-1501. (PMID: 29470151) Adv Clin Chem. 2015;70:247-314. (PMID: 26231489) Sports Med. 2001;31(11):785-807. (PMID: 11583104) PLoS Genet. 2011 Apr;7(4):e1002033. (PMID: 21490707) Eur J Nutr. 2023 Mar;62(2):1041-1050. (PMID: 36385314) Scand J Med Sci Sports. 2020 Oct;30(10):1869-1877. (PMID: 32538495) Am J Clin Nutr. 2012 Sep;96(3):665-71. (PMID: 22854411) Sports Med. 2018 Aug;48(8):1913-1928. (PMID: 29876876) Am J Psychiatry. 1981 Feb;138(2):178-83. (PMID: 7457638) Eur J Nutr. 2021 Apr;60(3):1181-1195. (PMID: 33137206) Anesthesiology. 1990 Jan;72(1):50-4. (PMID: 2136977) Am J Physiol. 1992 Jun;262(6 Pt 1):E891-8. (PMID: 1616022) J Appl Physiol (1985). 2011 Nov;111(5):1372-9. (PMID: 21836046) Mol Neurobiol. 2017 Oct;54(8):6245-6260. (PMID: 27714631) NPJ Genom Med. 2020 Oct 2;5:42. (PMID: 33083011) J Int Soc Sports Nutr. 2021 Jan 2;18(1):1. (PMID: 33388079) Int J Sports Physiol Perform. 2014 Nov;9(6):1013-8. (PMID: 24664858) Eur J Sport Sci. 2018 Mar;18(2):219-225. (PMID: 29087785) Curr Opin Pediatr. 2013 Dec;25(6):653-8. (PMID: 24240283) J Am Acad Child Adolesc Psychiatry. 1994 Mar-Apr;33(3):407-15. (PMID: 8169187) J Appl Physiol (1985). 2000 Nov;89(5):1719-24. (PMID: 11053318) PLoS One. 2016 Nov 18;11(11):e0165310. (PMID: 27861507) Nutrients. 2021 Jul 22;13(8):. (PMID: 34444663) Neurosci Biobehav Rev. 2009 Jun;33(6):793-806. (PMID: 19428492) Pharmacol Toxicol. 1995 Feb;76(2):93-101. (PMID: 7746802) Eur J Appl Physiol. 2021 Mar;121(3):749-769. (PMID: 33403509) Clin Genet. 2003 Feb;63(2):139-44. (PMID: 12630962) Chin J Physiol. 2019 Nov-Dec;62(6):279-284. (PMID: 31793465) J Appl Physiol (1985). 2013 Aug 1;115(3):355-64. (PMID: 23722705) Br J Clin Pharmacol. 2020 May;86(5):861-867. (PMID: 31782534) Am J Physiol. 1998 Aug;275(2):R596-603. (PMID: 9688698) Exerc Sport Sci Rev. 2004 Oct;32(4):143-7. (PMID: 15604932) Nature. 1979 Jul 19;280(5719):235-6. (PMID: 450140) |
المشرفين على المادة: | 3G6A5W338E (Caffeine) EC 3.4.15.1 (Peptidyl-Dipeptidase A) 0 (Performance-Enhancing Substances) |
تواريخ الأحداث: | Date Created: 20240619 Date Completed: 20240619 Latest Revision: 20240808 |
رمز التحديث: | 20240809 |
مُعرف محوري في PubMed: | PMC11186592 |
DOI: | 10.1590/1414-431X2024e13217 |
PMID: | 38896643 |
قاعدة البيانات: | MEDLINE |
تدمد: | 1414-431X |
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DOI: | 10.1590/1414-431X2024e13217 |