دورية أكاديمية
أعرض في EDS

ACE gene polymorphisms (rs4340) II and DI are more responsive to the ergogenic effect of caffeine than DD on aerobic power, heart rate, and perceived exertion in a homogeneous Brazilian group of adolescent athletes.

التفاصيل البيبلوغرافية
العنوان: ACE gene polymorphisms (rs4340) II and DI are more responsive to the ergogenic effect of caffeine than DD on aerobic power, heart rate, and perceived exertion in a homogeneous Brazilian group of adolescent athletes.
المؤلفون: Spineli H; Instituto de Educação Física e Esporte, Universidade Federal de Alagoas, Maceió, AL, Brasil., Santos MD; Instituto de Educação Física e Esporte, Universidade Federal de Alagoas, Maceió, AL, Brasil.; Instituto de Ciências Biológicas e da Saúde, Universidade Federal de Alagoas, Maceió, AL, Brasil., Almeida D; Instituto de Ciências Biológicas e da Saúde, Universidade Federal de Alagoas, Maceió, AL, Brasil., Gitaí D; Instituto de Ciências Biológicas e da Saúde, Universidade Federal de Alagoas, Maceió, AL, Brasil., Silva-Cavalcante M; Instituto Federal de Educação Ciência e Tecnologia de Alagoas, Maceió, AL, Brasil., Balikian P; Instituto de Educação Física e Esporte, Universidade Federal de Alagoas, Maceió, AL, Brasil., Ataide-Silva T; Faculdade de Nutrição, Universidade Federal de Alagoas, Maceió, AL, Brasil., Marinho A; Instituto de Educação Física e Esporte, Universidade Federal de Alagoas, Maceió, AL, Brasil., Sousa F; Instituto de Educação Física e Esporte, Universidade Federal de Alagoas, Maceió, AL, Brasil., Araujo G; Instituto de Educação Física e Esporte, Universidade Federal de Alagoas, Maceió, AL, Brasil.; Faculdade de Nutrição, Universidade Federal de Alagoas, Maceió, AL, Brasil.
المصدر: Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas [Braz J Med Biol Res] 2024 Jun 17; Vol. 57, pp. e13217. Date of Electronic Publication: 2024 Jun 17 (Print Publication: 2024).
نوع المنشور: Journal Article; Randomized Controlled Trial
اللغة: English
بيانات الدورية: Publisher: Associação Brasileira de Divulgação Científica Country of Publication: Brazil NLM ID: 8112917 Publication Model: eCollection Cited Medium: Internet ISSN: 1414-431X (Electronic) Linking ISSN: 0100879X NLM ISO Abbreviation: Braz J Med Biol Res Subsets: MEDLINE
أسماء مطبوعة: Original Publication: [SP, Brasil : Associação Brasileira de Divulgação Científica, 1981-
مواضيع طبية MeSH: Heart Rate*/drug effects , Caffeine*/administration & dosage , Genotype* , Athletes* , Physical Exertion*/physiology , Peptidyl-Dipeptidase A*/genetics, Humans ; Adolescent ; Male ; Athletic Performance/physiology ; Physical Endurance/drug effects ; Physical Endurance/genetics ; Polymorphism, Genetic/genetics ; Brazil ; Oxygen Consumption/genetics ; Oxygen Consumption/drug effects ; Performance-Enhancing Substances/administration & dosage
مستخلص: The purpose of this study was to verify the association between angiotensin-converting enzyme (ACE) genotypes DD, DI, and II and caffeine (CAF) ingestion on endurance performance, heart rate, ratio of perceived exertion (RPE), and habitual caffeine intake (HCI) of adolescent athletes. Seventy-four male adolescent athletes (age: DD=16±1.7; DI=16±2.0; II=15±1.7 years) ingested CAF (6 mg/kg) or placebo (PLA) one hour before performing the Yo-Yo Intermittent Recovery level 1 (Yo-Yo IR1) test. No difference was found among groups for HCI. However, CAF increased the maximal distance covered and VO2max in DI and II genotype carriers compared to PLA (DD: Δ=31 m and 0.3 mL·kg-1·min-1; DI: Δ=286 m and 1.1 mL·kg-1·min-1; II: Δ=160 m and 1.4 mL·kg-1·min-1). Heart rate of DI and II genotype carriers increased with CAF compared to PLA, while RPE was higher in the II and lower in the DD genotypes. The correlations between HCI and maximal distance covered or VO2max were significant in the II genotype carriers with CAF. CAF increased endurance capacity, heart rate, and RPE in adolescent athletes with allele I, while endurance performance and aerobic power had a positive correlation to HCI in the II genotype group. These findings suggested that DD genotype were less responsive to CAF and that genetic variations should be taken into account when using CAF supplementation to enhance exercise performance.
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المشرفين على المادة: 3G6A5W338E (Caffeine)
EC 3.4.15.1 (Peptidyl-Dipeptidase A)
0 (Performance-Enhancing Substances)
تواريخ الأحداث: Date Created: 20240619 Date Completed: 20240619 Latest Revision: 20240808
رمز التحديث: 20240809
مُعرف محوري في PubMed: PMC11186592
DOI: 10.1590/1414-431X2024e13217
PMID: 38896643
قاعدة البيانات: MEDLINE
الوصف
تدمد:1414-431X
DOI:10.1590/1414-431X2024e13217