دورية أكاديمية
Chitosan based ethanolic Allium Sativum extract hydrogel film: a novel skin tissue regeneration platform for 2nd degree burn wound healing.
| العنوان: | Chitosan based ethanolic Allium Sativum extract hydrogel film: a novel skin tissue regeneration platform for 2nd degree burn wound healing. |
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| المؤلفون: | Wang J; Department of Dermatology, The First Affiliated Hospital of Xi'an Medical University, Xi'an 710004, People's Republic of China., Ismail M; Department of Pharmacy, Kohat University of Science and Technology, Kohat 26000 KP, Pakistan., Khan NR; Department of Pharmacy, Kohat University of Science and Technology, Kohat 26000 KP, Pakistan., Khan DE; Department of Pharmacy, Bacha Khan University Charsadda, Charsadda, KP 24540, Pakistan., Iftikhar T; Department of Pharmacy, Abdul Wali Khan University Mardan, Mardan, KP 23200, Pakistan., Shahid MG; Department of Botany, Government College University, Lahore 54000 Punjab, Pakistan., Shah SU; Faculty of Pharmacy, Gomal University, DIKhan 29050 KP, Pakistan., Rehman ZU; Department of Pharmacy, Kohat University of Science and Technology, Kohat 26000 KP, Pakistan. |
| المصدر: | Biomedical materials (Bristol, England) [Biomed Mater] 2024 Jun 20; Vol. 19 (4). Date of Electronic Publication: 2024 Jun 20. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Institute of Physics Pub Country of Publication: England NLM ID: 101285195 Publication Model: Electronic Cited Medium: Internet ISSN: 1748-605X (Electronic) Linking ISSN: 17486041 NLM ISO Abbreviation: Biomed Mater Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Bristol, UK : Institute of Physics Pub., |
| مواضيع طبية MeSH: | Chitosan*/chemistry , Wound Healing*/drug effects , Garlic*/chemistry , Burns*/therapy , Burns*/drug therapy , Plant Extracts*/chemistry , Plant Extracts*/pharmacology , Tensile Strength* , Skin*/drug effects , Skin*/pathology , Hydrogels*/chemistry, Animals ; Rats ; Male ; Ethanol/chemistry ; Regeneration/drug effects ; Permeability ; Steam ; Biocompatible Materials/chemistry ; Biocompatible Materials/pharmacology ; Methylgalactosides |
| مستخلص: | This study investigated the potential of ethanolic garlic extract-loaded chitosan hydrogel film for burn wound healing in an animal model. The ethanolic garlic extract was prepared by macerating fresh ground garlic cloves in ethanol for 24 h, followed by filtration and concentration using a rotary evaporator. Hydrogels were then prepared by casting a chitosan solution with garlic extract added at varying concentrations for optimization and, following drying, subjected to various characterization tests, including moisture adsorption (MA), water vapor transmission rate (WVTR), and water vapor permeability rate (WVPR), erosion, swelling, tensile strength, vibrational, and thermal analysis, and surface morphology. The optimized hydrogel (G2) was then analyzed in vivo for its potential for healing 2nd degree burn wounds in rats, and histological examination of skin samples on day 14 of the healing period. Results showed optimized hydrogel (G2; chitosan: 2 g, garlic extract: 1 g) had MA of 56.8% ± 2.7%, WVTR and WVPR of 0.00074 ± 0.0002, and 0.000 498 946 ± 0.0001, eroded up to 11.3% ± 0.05%, 80.7% ± 0.04% of swelling index, and tensile strength of 16.6 ± 0.9 MPa, which could be attributed to the formation of additional linkages between formulation ingredients and garlic extract constituents at OH/NH and C=O, translating into an increase in transition melting temperature and enthalpy (Δ T = 238.83 °C ± 1.2 °C, Δ H = 4.95 ± 0.8 J g -1 ) of the chitosan moieties compared with blank. Animal testing revealed G2 formulation significantly reduced the wound size within 14 d of the experiment (37.3 ± 6.8-187.5 ± 21.5 mm 2 ) and had significantly higher reepithelization (86.3 ± 6.8-26.8 ± 21.5 and 38.2% ± 15.3%) compared to untreated and blank groups by hastening uniform and compact deposition of collagen fibers at the wound site, cementing developed formulation a promising platform for skin regeneration. (Creative Commons Attribution license.) |
| فهرسة مساهمة: | Keywords: burn wound; film; garlic extract; hydrogel; skin tissue regeneration |
| المشرفين على المادة: | 9012-76-4 (Chitosan) 0 (Plant Extracts) 0 (Hydrogels) 3K9958V90M (Ethanol) 0 (hydrogel film) 0 (Steam) 0 (Biocompatible Materials) 0 (Methylgalactosides) |
| تواريخ الأحداث: | Date Created: 20240620 Date Completed: 20240620 Latest Revision: 20240620 |
| رمز التحديث: | 20240620 |
| DOI: | 10.1088/1748-605X/ad565b |
| PMID: | 38898715 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1748-605X |
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| DOI: | 10.1088/1748-605X/ad565b |