دورية أكاديمية
أعرض في EDS

Association Between Patient Sex and Familial Hypercholesterolemia and Long-Term Cardiovascular Risk Factor Management 5 Years After Acute Coronary Syndrome.

التفاصيل البيبلوغرافية
العنوان: Association Between Patient Sex and Familial Hypercholesterolemia and Long-Term Cardiovascular Risk Factor Management 5 Years After Acute Coronary Syndrome.
المؤلفون: Krasieva K; Center for Primary Care and Public Health (Unisanté), University of Lausanne, Switzerland (K.K., I.L., D.N.)., Gencer B; Service of Cardiology, Geneva University Hospital, Switzerland (B.G., D.C., F.M.).; Institute of Primary Health Care (BIHAM), University of Bern, Switzerland (B.G., N.R.).; Service of Cardiology, Lausanne University Hospital, Switzerland (B.G., O.M., S.F.)., Locatelli I; Center for Primary Care and Public Health (Unisanté), University of Lausanne, Switzerland (K.K., I.L., D.N.)., Carballo D; Service of Cardiology, Geneva University Hospital, Switzerland (B.G., D.C., F.M.)., Muller O; Service of Cardiology, Lausanne University Hospital, Switzerland (B.G., O.M., S.F.)., Fournier S; Service of Cardiology, Lausanne University Hospital, Switzerland (B.G., O.M., S.F.)., Matter CM; University Heart Center, Department of Cardiology, Zurich University Hospital, and Center of Translational and Experimental Cardiology, Department of Cardiology, Zurich University Hospital and University of Zurich, Switzerland (C.M.M.)., Räber L; Department of Cardiology, Inselspital, Bern University Hospital, University of Bern, Switzerland (L.R.)., Rodondi N; Institute of Primary Health Care (BIHAM), University of Bern, Switzerland (B.G., N.R.).; Department of General Internal Medicine, Inselspital, Bern University Hospital, Switzerland (N.R.)., Mach F; Service of Cardiology, Geneva University Hospital, Switzerland (B.G., D.C., F.M.)., Nanchen D; Center for Primary Care and Public Health (Unisanté), University of Lausanne, Switzerland (K.K., I.L., D.N.).
المصدر: Circulation. Cardiovascular quality and outcomes [Circ Cardiovasc Qual Outcomes] 2024 Aug; Vol. 17 (8), pp. e010790. Date of Electronic Publication: 2024 Jun 20.
نوع المنشور: Journal Article; Multicenter Study; Comparative Study; Observational Study
اللغة: English
بيانات الدورية: Publisher: Lippincott Williams & Wilkins Country of Publication: United States NLM ID: 101489148 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1941-7705 (Electronic) Linking ISSN: 19417713 NLM ISO Abbreviation: Circ Cardiovasc Qual Outcomes Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Hagerstown, MD : Lippincott Williams & Wilkins
مواضيع طبية MeSH: Acute Coronary Syndrome*/diagnosis , Acute Coronary Syndrome*/epidemiology , Acute Coronary Syndrome*/therapy , Acute Coronary Syndrome*/blood , Hyperlipoproteinemia Type II*/diagnosis , Hyperlipoproteinemia Type II*/blood , Hyperlipoproteinemia Type II*/drug therapy , Hyperlipoproteinemia Type II*/epidemiology , Hyperlipoproteinemia Type II*/complications , Cholesterol, LDL*/blood , Biomarkers*/blood , Heart Disease Risk Factors* , Hydroxymethylglutaryl-CoA Reductase Inhibitors*/therapeutic use, Humans ; Male ; Female ; Middle Aged ; Sex Factors ; Aged ; Time Factors ; Prospective Studies ; Treatment Outcome ; Switzerland/epidemiology ; Risk Assessment ; Recurrence ; Healthcare Disparities ; Secondary Prevention ; Health Status Disparities
مستخلص: Background: Long-term control of cardiovascular risk factors after acute coronary syndrome (ACS) is the cornerstone for preventing recurrence. We investigated the extent of cardiovascular risk factor management in males and females with and without familial hypercholesterolemia (FH) 5 years after ACS.
Methods: We studied patients hospitalized for ACS between 2009 and 2017 in a Swiss multicenter prospective cohort study. FH was defined based on clinical criteria from the Dutch Lipid Clinic Network and Simon Broome definitions. Five years post-ACS, we assessed low-density lipoprotein-cholesterol (LDL-c) levels, lipid-lowering therapy (LLT), and other cardiovascular risk factors, comparing males to females with and without FH using generalized estimating equations.
Results: A total of 3139 patients were included; mean age was 61.4 years (SD, 12.1), 620 (19.8%) were female, and 747 (23.5%) had possible FH. Compared with males at 5-years post-ACS, females were more likely to not use statins (odds ratio, 1.61 [95% CI, 1.28-2.03]) and less likely to have combination LLT (odds ratio, 0.72 [95% CI, 0.55-0.93]), without difference between patients with FH and without FH. Females in both FH and non-FH groups less frequently reached LDL-c values ≤1.8 mmol/L (odds ratio, 0.78 [95% CI, 0.78-0.93]). Overall, patients with FH were more frequently on high-dose statins compared with patients without FH (51.0% versus 42.9%; P =0.001) and presented more frequently with a combination of 2 or more LLT compared with patients without FH (33.8% versus 17.7%; P <0.001), but less frequently reached LDL-c targets of ≤1.8 mmol/L (33.5% versus 44.3%; P <0.001) or ≤2.6 mmol/L (70.2% versus 78.1%; P =0.001).
Conclusions: Five years after ACS, females had less intensive LLT and were less likely to reach target LDL-c levels than males, regardless of FH status. Males and females with FH had less optimal control of LDL-c despite more frequently taking high-dose statins or combination LLT compared with patients without FH. Long-term management of patients with ACS and FH, especially females, warrants optimization.
Competing Interests: Dr Matter reports receiving grants from Merck Sharp & Dohme, Eli Lilly, AstraZeneca, Roche, Bayer, Novo Nordisk; expert testimony from Merck Sharp & Dohme; payment for lectures from Merck Sharp & Dohme, AstraZeneca, and Roche. Dr Mach has received honoraria for advisory boards and conferences on dyslipidemia from Amgen, AstraZeneca, Bristol Myers Squibb, Eli Lilly, Merck Sharp & Dohme, Sanofi, and Pfizer. The other authors report no conflicts.
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فهرسة مساهمة: Keywords: acute coronary syndrome; hyperlipoproteinemia type II; lipids; lipoproteins, LDL; risk factors
المشرفين على المادة: 0 (Cholesterol, LDL)
0 (Biomarkers)
0 (Hydroxymethylglutaryl-CoA Reductase Inhibitors)
تواريخ الأحداث: Date Created: 20240620 Date Completed: 20240821 Latest Revision: 20240823
رمز التحديث: 20240823
مُعرف محوري في PubMed: PMC11338030
DOI: 10.1161/CIRCOUTCOMES.123.010790
PMID: 38899458
قاعدة البيانات: MEDLINE
الوصف
تدمد:1941-7705
DOI:10.1161/CIRCOUTCOMES.123.010790