دورية أكاديمية
Silicon or Calcium Doping Coordinates the Immunostimulatory Effects of Aluminum Oxyhydroxide Nanoadjuvants in Prophylactic Vaccines.
| العنوان: | Silicon or Calcium Doping Coordinates the Immunostimulatory Effects of Aluminum Oxyhydroxide Nanoadjuvants in Prophylactic Vaccines. |
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| المؤلفون: | Li M; State Key Laboratory of Fine Chemicals, Dalian University of Technology, 2 Linggong Road, Dalian 116024, China.; School of Chemical Engineering, Dalian University of Technology, 2 Linggong Road, Dalian 116024, China.; Frontiers Science Center for Smart Materials Oriented Chemical Engineering, School of Chemical Engineering, Dalian University of Technology, 2 Linggong Road, Dalian 116024, China., Yao Z; State Key Laboratory of Fine Chemicals, Dalian University of Technology, 2 Linggong Road, Dalian 116024, China.; School of Chemical Engineering, Dalian University of Technology, 2 Linggong Road, Dalian 116024, China.; Frontiers Science Center for Smart Materials Oriented Chemical Engineering, School of Chemical Engineering, Dalian University of Technology, 2 Linggong Road, Dalian 116024, China., Wang H; State Key Laboratory of Fine Chemicals, Dalian University of Technology, 2 Linggong Road, Dalian 116024, China.; School of Chemical Engineering, Dalian University of Technology, 2 Linggong Road, Dalian 116024, China.; Frontiers Science Center for Smart Materials Oriented Chemical Engineering, School of Chemical Engineering, Dalian University of Technology, 2 Linggong Road, Dalian 116024, China., Ma Y; State Key Laboratory of Fine Chemicals, Dalian University of Technology, 2 Linggong Road, Dalian 116024, China.; School of Chemical Engineering, Dalian University of Technology, 2 Linggong Road, Dalian 116024, China.; Frontiers Science Center for Smart Materials Oriented Chemical Engineering, School of Chemical Engineering, Dalian University of Technology, 2 Linggong Road, Dalian 116024, China., Yang W; State Key Laboratory of Fine Chemicals, Dalian University of Technology, 2 Linggong Road, Dalian 116024, China.; School of Chemical Engineering, Dalian University of Technology, 2 Linggong Road, Dalian 116024, China.; Frontiers Science Center for Smart Materials Oriented Chemical Engineering, School of Chemical Engineering, Dalian University of Technology, 2 Linggong Road, Dalian 116024, China., Guo Y; State Key Laboratory of Fine Chemicals, Dalian University of Technology, 2 Linggong Road, Dalian 116024, China.; School of Chemical Engineering, Dalian University of Technology, 2 Linggong Road, Dalian 116024, China.; Frontiers Science Center for Smart Materials Oriented Chemical Engineering, School of Chemical Engineering, Dalian University of Technology, 2 Linggong Road, Dalian 116024, China., Yu G; State Key Laboratory of Fine Chemicals, Dalian University of Technology, 2 Linggong Road, Dalian 116024, China.; School of Chemical Engineering, Dalian University of Technology, 2 Linggong Road, Dalian 116024, China.; Frontiers Science Center for Smart Materials Oriented Chemical Engineering, School of Chemical Engineering, Dalian University of Technology, 2 Linggong Road, Dalian 116024, China., Shi W; State Key Laboratory of Fine Chemicals, Dalian University of Technology, 2 Linggong Road, Dalian 116024, China.; School of Chemical Engineering, Dalian University of Technology, 2 Linggong Road, Dalian 116024, China.; Frontiers Science Center for Smart Materials Oriented Chemical Engineering, School of Chemical Engineering, Dalian University of Technology, 2 Linggong Road, Dalian 116024, China., Zhang N; State Key Laboratory of Fine Chemicals, Dalian University of Technology, 2 Linggong Road, Dalian 116024, China.; School of Chemical Engineering, Dalian University of Technology, 2 Linggong Road, Dalian 116024, China.; Frontiers Science Center for Smart Materials Oriented Chemical Engineering, School of Chemical Engineering, Dalian University of Technology, 2 Linggong Road, Dalian 116024, China., Xu M; State Key Laboratory of Fine Chemicals, Dalian University of Technology, 2 Linggong Road, Dalian 116024, China.; School of Chemical Engineering, Dalian University of Technology, 2 Linggong Road, Dalian 116024, China.; Frontiers Science Center for Smart Materials Oriented Chemical Engineering, School of Chemical Engineering, Dalian University of Technology, 2 Linggong Road, Dalian 116024, China., Li X; State Key Laboratory of Fine Chemicals, Dalian University of Technology, 2 Linggong Road, Dalian 116024, China.; School of Chemical Engineering, Dalian University of Technology, 2 Linggong Road, Dalian 116024, China.; Frontiers Science Center for Smart Materials Oriented Chemical Engineering, School of Chemical Engineering, Dalian University of Technology, 2 Linggong Road, Dalian 116024, China., Zhao J; State Key Laboratory of Fine Chemicals, Dalian University of Technology, 2 Linggong Road, Dalian 116024, China.; School of Chemical Engineering, Dalian University of Technology, 2 Linggong Road, Dalian 116024, China.; Frontiers Science Center for Smart Materials Oriented Chemical Engineering, School of Chemical Engineering, Dalian University of Technology, 2 Linggong Road, Dalian 116024, China., Zhang Y; State Key Laboratory of Fine Chemicals, Dalian University of Technology, 2 Linggong Road, Dalian 116024, China.; School of Chemical Engineering, Dalian University of Technology, 2 Linggong Road, Dalian 116024, China.; Frontiers Science Center for Smart Materials Oriented Chemical Engineering, School of Chemical Engineering, Dalian University of Technology, 2 Linggong Road, Dalian 116024, China., Xue C; School of Bioengineering, Dalian University of Technology, 2 Linggong Road, Dalian 116024, China., Sun B; State Key Laboratory of Fine Chemicals, Dalian University of Technology, 2 Linggong Road, Dalian 116024, China.; School of Chemical Engineering, Dalian University of Technology, 2 Linggong Road, Dalian 116024, China.; Frontiers Science Center for Smart Materials Oriented Chemical Engineering, School of Chemical Engineering, Dalian University of Technology, 2 Linggong Road, Dalian 116024, China. |
| المصدر: | ACS nano [ACS Nano] 2024 Jul 02; Vol. 18 (26), pp. 16878-16894. Date of Electronic Publication: 2024 Jun 20. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: American Chemical Society Country of Publication: United States NLM ID: 101313589 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1936-086X (Electronic) Linking ISSN: 19360851 NLM ISO Abbreviation: ACS Nano Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Washington D.C. : American Chemical Society |
| مواضيع طبية MeSH: | Adjuvants, Immunologic*/chemistry , Adjuvants, Immunologic*/pharmacology , Silicon*/chemistry , Hepatitis B Surface Antigens*/immunology , Hepatitis B Surface Antigens*/chemistry , Calcium*/chemistry , Aluminum Hydroxide*/chemistry , Aluminum Hydroxide*/pharmacology, Animals ; Mice ; Mice, Inbred C57BL ; Female ; Vaccines/immunology ; Vaccines/chemistry ; Dendritic Cells/immunology ; Dendritic Cells/drug effects ; Nanoparticles/chemistry ; Humans ; Aluminum Oxide |
| مستخلص: | Aluminum salts still remain as the most popular adjuvants in marketed human prophylactic vaccines due to their capability to trigger humoral immune responses with a good safety record. However, insufficient induction of cellular immune responses limits their further applications. In this study, we prepare a library of silicon (Si)- or calcium (Ca)-doped aluminum oxyhydroxide (AlOOH) nanoadjuvants. They exhibit well-controlled physicochemical properties, and the dopants are homogeneously distributed in nanoadjuvants. By using Hepatitis B surface antigen (HBsAg) as the model antigen, doped AlOOH nanoadjuvants mediate higher antigen uptake and promote lysosome escape of HBsAg through lysosomal rupture induced by the dissolution of the dopant in the lysosomes in bone marrow-derived dendritic cells (BMDCs). Additionally, doped nanoadjuvants trigger higher antigen accumulation and immune cell activation in draining lymph nodes. In HBsAg and varicella-zoster virus glycoprotein E (gE) vaccination models, doped nanoadjuvants induce high IgG titer, activations of CD4 + and CD8 + T cells, cytotoxic T lymphocytes, and generations of effector memory T cells. Doping of aluminum salt-based adjuvants with biological safety profiles and immunostimulating capability is a potential strategy to mediate robust humoral and cellular immunity. It potentiates the applications of engineered adjuvants in the development of vaccines with coordinated immune responses. |
| فهرسة مساهمة: | Keywords: aluminum oxyhydroxide; cellular immunity; doping; vaccine adjuvant; varicella-zoster virus glycoprotein E |
| المشرفين على المادة: | 0 (Adjuvants, Immunologic) Z4152N8IUI (Silicon) 0 (Hepatitis B Surface Antigens) SY7Q814VUP (Calcium) 63957-70-0 (aluminum oxide hydroxide) 5QB0T2IUN0 (Aluminum Hydroxide) 0 (Vaccines) LMI26O6933 (Aluminum Oxide) |
| تواريخ الأحداث: | Date Created: 20240620 Date Completed: 20240702 Latest Revision: 20240702 |
| رمز التحديث: | 20240702 |
| DOI: | 10.1021/acsnano.4c02685 |
| PMID: | 38899978 |
| قاعدة البيانات: | MEDLINE |
Find this issue from the American Chemical Society | تدمد: | 1936-086X |
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| DOI: | 10.1021/acsnano.4c02685 |