دورية أكاديمية
أعرض في EDS

Prevalence and risk factors of transmission of hepatitis delta virus in pregnant women in the Center Region of Cameroon.

التفاصيل البيبلوغرافية
العنوان: Prevalence and risk factors of transmission of hepatitis delta virus in pregnant women in the Center Region of Cameroon.
المؤلفون: Ndzie Ondigui JL; Faculty of Sciences, Department of Microbiology, University of Yaoundé 1, Yaounde, Cameroon.; Chantal BIYA' International Reference Center for Research on HIV/AIDS Prevention and Management (CIRCB), Yaounde, Cameroon., Mafopa Goumkwa N; Chantal BIYA' International Reference Center for Research on HIV/AIDS Prevention and Management (CIRCB), Yaounde, Cameroon., Lobe C; Chantal BIYA' International Reference Center for Research on HIV/AIDS Prevention and Management (CIRCB), Yaounde, Cameroon.; Department of Food Science and Nutrition, National School of Agro-Industrial Sciences, University of Ngaoundere, Ngaoundere, Cameroon., Wandji B; Yaoundé Gyanecology Obstetrics and Paediatrics Hospital, Yaounde, Cameroon., Awoumou P; Chantal BIYA' International Reference Center for Research on HIV/AIDS Prevention and Management (CIRCB), Yaounde, Cameroon.; Faculty of Medicine and Biomedical Sciences, Department of Biochemistry, University of Yaounde 1, Yaounde, Cameroon., Voussou Djivida P; Faculty of Medicine and Biomedical Sciences, Department of Biochemistry, University of Yaounde 1, Yaounde, Cameroon., Peyonga P; Faculty of Medicine and Biomedical Sciences, Department of Biochemistry, University of Yaounde 1, Yaounde, Cameroon., Manju Atah S; Faculty of Medicine and Biomedical Sciences, Department of Public Health, University of Yaounde 1, Yaounde, Cameroon., Verbe V; Cité Verte District Hospital, Yaounde, Cameroon., Kamgaing Simo R; Chantal BIYA' International Reference Center for Research on HIV/AIDS Prevention and Management (CIRCB), Yaounde, Cameroon., Moudourou SA; Chantal BIYA' International Reference Center for Research on HIV/AIDS Prevention and Management (CIRCB), Yaounde, Cameroon., Gutierrez A; Bikop Catholic Health Center, Bikop, Cameroon., Garcia R; Bikop Catholic Health Center, Bikop, Cameroon., Fernandez I; Bikop Catholic Health Center, Bikop, Cameroon., Riwom Essama SH; Faculty of Sciences, Department of Microbiology, University of Yaoundé 1, Yaounde, Cameroon., Mbu R; Yaoundé Gyanecology Obstetrics and Paediatrics Hospital, Yaounde, Cameroon.; Faculty of Medicine and Biomedical Sciences, Department of Gynecology/Obstetrics, University of Yaounde 1, Yaounde, Cameroon., Torimiro J; Chantal BIYA' International Reference Center for Research on HIV/AIDS Prevention and Management (CIRCB), Yaounde, Cameroon.; Faculty of Medicine and Biomedical Sciences, Department of Biochemistry, University of Yaounde 1, Yaounde, Cameroon.
المصدر: PloS one [PLoS One] 2024 Jun 20; Vol. 19 (6), pp. e0287491. Date of Electronic Publication: 2024 Jun 20 (Print Publication: 2024).
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Public Library of Science Country of Publication: United States NLM ID: 101285081 Publication Model: eCollection Cited Medium: Internet ISSN: 1932-6203 (Electronic) Linking ISSN: 19326203 NLM ISO Abbreviation: PLoS One Subsets: MEDLINE
أسماء مطبوعة: Original Publication: San Francisco, CA : Public Library of Science
مواضيع طبية MeSH: Hepatitis D*/epidemiology , Hepatitis D*/transmission , Hepatitis Delta Virus*/genetics , Hepatitis Delta Virus*/immunology , Pregnancy Complications, Infectious*/epidemiology , Pregnancy Complications, Infectious*/virology , Infectious Disease Transmission, Vertical*, Humans ; Female ; Pregnancy ; Cameroon/epidemiology ; Adult ; Risk Factors ; Cross-Sectional Studies ; Prevalence ; Young Adult ; Seroepidemiologic Studies ; Hepatitis B Surface Antigens/blood ; Hepatitis B/epidemiology ; Hepatitis B/transmission ; Hepatitis B/virology ; Coinfection/epidemiology ; Coinfection/virology
مستخلص: Background: Hepatitis B virus (HBV) and hepatitis delta virus (HDV) co-infection has been described as the most severe form of viral hepatitis, and can be co-transmitted from mother-to-child. A seroprevalence of 4.0% of HDV infection was reported in pregnant women in Yaoundé, and 11.9% in the general population in Cameroon. Our objective was to describe the rate of HDV infection in HBsAg-positive pregnant women and to determine risk factors associated with mother-to-child transmission of HDV.
Materials and Methods: A cross-sectional, descriptive study was conducted from January 2019 to July 2022 among pregnant women attending antenatal contacts in seven health structures in the Centre Region of Cameroon. A consecutive sampling (non-probability sampling) was used to select only pregnant women of age over 21 years, who gave a written informed consent. Following an informed consent, an open-ended questionnaire was used for a Knowledge, Attitude and Practice (KAP) survey of these women, and their blood specimens collected and screened for HBsAg, anti-HIV and anti-HCV antibodies by rapid tests and ELISA. HBsAg-positive samples were further screened for HBeAg, anti-HDV, anti-HBs, and anti HBc antibodies by ELISA, and plasma HDV RNA load measured by RT-qPCR.
Results: Of 1992 pregnant women, a rate of 6.7% of HBsAg (133/1992) with highest rate in the rural areas, and 3.9% of hepatitis vaccination rate were recorded. Of 130, 42 (32.3%) were anti-HDV antibody-positive, and 47.6% had detectable HDV RNA viraemia. Of 44 anti-HDV-positive cases, 2 (4.5%) were co-infected with HBV and HCV, while 5 (11.4%) with HIV and HBV. Multiple pregnancies, the presence of tattoos and/or scarifications were significantly associated with the presence of anti-HDV antibodies. Of note, 80% of women with negative HBeAg and positive anti-HBe serological profile, had plasma HDV RNA load of more than log 3.25 (>10.000 copies/ml).
Conclusion: These results show an intermediate rate of HDV infection among pregnant women with high level of HDV RNA viremia, which suggest an increased risk of vertical and horizontal co-transmission of HDV.
Competing Interests: The authors have declared that no competing interests exist.
(Copyright: © 2024 Ndzie Ondigui et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.)
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المشرفين على المادة: 0 (Hepatitis B Surface Antigens)
تواريخ الأحداث: Date Created: 20240620 Date Completed: 20240620 Latest Revision: 20240622
رمز التحديث: 20240622
مُعرف محوري في PubMed: PMC11189217
DOI: 10.1371/journal.pone.0287491
PMID: 38900729
قاعدة البيانات: MEDLINE
الوصف
تدمد:1932-6203
DOI:10.1371/journal.pone.0287491