دورية أكاديمية
Effect of Lipopolysaccharide on the Duration of Zolpidem-Induced Loss of Righting Reflex in Mice.
| العنوان: | Effect of Lipopolysaccharide on the Duration of Zolpidem-Induced Loss of Righting Reflex in Mice. |
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| المؤلفون: | Wada Y; Department of Clinical Pharmacy, Okayama University, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences., Ushio S; Department of Pharmacy, Okayama University Hospital.; Department of Physiology and Pharmacology, Faculty of Pharmaceutical Sciences, Fukuoka University., Kitamura Y; Department of Clinical Pharmacy, Okayama University, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences.; Department of Pharmacy, Okayama University Hospital.; Department of Pharmacotherapy, School of Pharmacy, Shujitsu University., Zamami Y; Department of Clinical Pharmacy, Okayama University, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences.; Department of Pharmacy, Okayama University Hospital., Sendo T; Department of Clinical Pharmacy, Okayama University, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences.; Department of Pharmacy, Okayama University Hospital. |
| المصدر: | Acta medica Okayama [Acta Med Okayama] 2024 Jun; Vol. 78 (3), pp. 227-235. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Okayama University Medical School Country of Publication: Japan NLM ID: 0417611 Publication Model: Print Cited Medium: Internet ISSN: 0386-300X (Print) Linking ISSN: 0386300X NLM ISO Abbreviation: Acta Med Okayama Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Okayama : Okayama University Medical School |
| مواضيع طبية MeSH: | Zolpidem*/pharmacology , Lipopolysaccharides* , Pyridines*/pharmacology , Receptors, GABA-A*/metabolism , Receptors, GABA-A*/drug effects , Symporters*/genetics , Symporters*/metabolism , Reflex, Righting*/drug effects, Animals ; Mice ; Male ; Hippocampus/drug effects ; Hippocampus/metabolism ; K Cl- Cotransporters ; Hypnotics and Sedatives/pharmacology ; Inflammation/chemically induced ; Frontal Lobe/drug effects ; Frontal Lobe/metabolism |
| مستخلص: | Zolpidem, a non-benzodiazepine hypnotic, is primarily used to treat insomnia. In a previous study, pior treatment with non-benzodiazepine receptor agonists was associated with inflammation. The present study aimed to clarify the association between the effects of zolpidem and inflammation in mice treated with lipopolysaccharide (LPS), a known model of inflammation. We assessed the zolpidem-induced loss of righting reflex (LORR) duration 24 h after LPS treatment in mice. Additionally, the expressions of γ-aminobutyric acid (GABA)A receptor subunit and K+-Cl- cotransporter isoform 2 (KCC2) mRNA in the hippocampus and frontal cortex were examined in LPS-treated mice. Pretreatment with LPS was associated with significantly prolonged duration of zolpidem-induced LORR compared to control mice. This effect was significantly attenuated by administering bicuculline, a GABAA receptor antagonist, or flumazenil, a benzodiazepine receptor antagonist, in LPS-treated mice. Compared to controls, LPS-treated mice showed no significant change in the expression of GABAA receptor subunits in the hippocampus or frontal cortex. Bumetanide, an Na+-K+-2Cl- cotransporter isoform 1 blocker, attenuated the extended duration of zolpidem-induced LORR observed in LPS-treated mice. LPS significantly decreased Kcc2 mRNA expression in the hippocampus and the frontal cortex. These findings suggest that inflammation increases zolpidem-induced LORR, possibly through a reduction in KCC2 expression. Competing Interests: No potential conflict of interest relevant to this article was reported. |
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| فهرسة مساهمة: | Keywords: GABAA receptor; K+-Cl− cotransporters; lipopolysaccharide; zolpidem |
| المشرفين على المادة: | 7K383OQI23 (Zolpidem) 0 (Lipopolysaccharides) 0 (Pyridines) 0 (Receptors, GABA-A) 0 (Symporters) 0 (K Cl- Cotransporters) 0 (Hypnotics and Sedatives) |
| تواريخ الأحداث: | Date Created: 20240620 Date Completed: 20240620 Latest Revision: 20240620 |
| رمز التحديث: | 20240621 |
| DOI: | 10.18926/AMO/67197 |
| PMID: | 38902210 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 0386-300X |
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| DOI: | 10.18926/AMO/67197 |