دورية أكاديمية
Nodal degree centrality in the default mode-like network of the TgF344-AD Alzheimer's disease rat model as a measure of early network alterations.
| العنوان: | Nodal degree centrality in the default mode-like network of the TgF344-AD Alzheimer's disease rat model as a measure of early network alterations. |
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| المؤلفون: | Amiri S; Neuroscience Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran., van den Berg M; Bio-Imaging Lab, University of Antwerp, Antwerp, Belgium.; µNEURO Research Centre of Excellence, University of Antwerp, Antwerp, Belgium., Nazem-Zadeh MR; Research Center for Molecular and Cellular Imaging, Tehran University of Medical Sciences, Tehran, Iran.; Department of neuroscience, Monash university, Melbourne, Vic, Australia., Verhoye M; Bio-Imaging Lab, University of Antwerp, Antwerp, Belgium.; µNEURO Research Centre of Excellence, University of Antwerp, Antwerp, Belgium., Amiri M; Medical Technology Research Center, Institute of Health Technology, Kermanshah University of Medical Sciences, Kermanshah, Iran. ma_amiri_bme@yahoo.com., Keliris GA; Bio-Imaging Lab, University of Antwerp, Antwerp, Belgium. georgios.keliris@outlook.com.; µNEURO Research Centre of Excellence, University of Antwerp, Antwerp, Belgium. georgios.keliris@outlook.com.; Institute of Computer Science, Hellas Foundation for Research & Technology - Hellas, Heraklion, Crete, Greece. georgios.keliris@outlook.com. |
| المصدر: | Npj aging [NPJ Aging] 2024 Jun 20; Vol. 10 (1), pp. 29. Date of Electronic Publication: 2024 Jun 20. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Springer Nature Country of Publication: England NLM ID: 9918402285106676 Publication Model: Electronic Cited Medium: Internet ISSN: 2731-6068 (Electronic) Linking ISSN: 27316068 NLM ISO Abbreviation: NPJ Aging Subsets: PubMed not MEDLINE |
| أسماء مطبوعة: | Original Publication: [London] : Springer Nature, [2022]- |
| مستخلص: | This study investigates brain network alterations in the default mode-like network (DMLN) at early stages of disease progression in a rat model of Alzheimer's disease (AD) with application in the development of early diagnostic biomarkers of AD in translational studies. Thirteen male TgF344-AD (TG) rats, and eleven male wild-types (WT) littermates underwent longitudinal resting-state fMRI at the age of 4 and 6 months (pre and early-plaque stages of AD). Alterations in connectivity within DMLN were characterized by calculating the nodal degree (ND), a graph theoretical measure of centrality. The ND values of the left CA2 subregion of the hippocampus was found to be significantly lower in the 4-month-old TG cohort compared to the age-matched WT littermates. Moreover, a lower ND value (hypo-connectivity) was observed in the right prelimbic cortex (prL) and basal forebrain in the 6-month-old TG cohort, compared to the same age WT cohort. Indeed, the ND pattern in the DMLN in both TG and WT cohorts showed significant differences across the two time points that represent pre-plaque and early plaque stages of disease progression. Our findings indicate that lower nodal degree (hypo-connectivity) in the left CA2 in the pre-plaque stage of AD and hypo-connectivity between the basal forebrain and the DMLN regions in the early-plaque stage demonstrated differences in comparison to healthy controls. These results suggest that a graph-theoretical measure such as the nodal degree, can characterize brain networks and improve our insights into the mechanisms underlying Alzheimer's disease. (© 2024. The Author(s).) |
| References: | Alzheimers Dement. 2016 Sep;12(9):964-976. (PMID: 27107518) Front Syst Neurosci. 2010 Jun 17;4:22. (PMID: 20592949) Alzheimers Dement. 2008 Jul;4(4):265-70. (PMID: 18631977) Front Aging Neurosci. 2020 Oct 22;12:576627. (PMID: 33192468) Annu Rev Psychol. 2017 Jan 3;68:19-45. (PMID: 27687117) Arch Neurol. 2007 Oct;64(10):1482-7. (PMID: 17923631) Clin Neuropharmacol. 2021 Jan-Feb 01;44(1):9-16. (PMID: 33337622) Psychiatr Times. 2018 Nov;35(11):14-17. (PMID: 30820070) PLoS One. 2017 Aug 1;12(8):e0178798. (PMID: 28763447) Neurosci Lett. 2021 Jun 11;755:135895. (PMID: 33862141) Hum Brain Mapp. 2021 Jun 15;42(9):2941-2968. (PMID: 33942449) Eur Neuropsychopharmacol. 2010 Aug;20(8):519-34. (PMID: 20471808) Radiology. 2019 Jan;290(1):167-176. (PMID: 30351255) Alzheimers Res Ther. 2022 Oct 10;14(1):148. (PMID: 36217211) Proc Natl Acad Sci U S A. 2012 Mar 6;109(10):3979-84. (PMID: 22355129) J Neurosci. 2013 Apr 10;33(15):6245-56. (PMID: 23575824) Neurosci Biobehav Rev. 2021 Jul;126:398-412. (PMID: 33775693) Epilepsy Behav. 2021 Jan;114(Pt A):107565. (PMID: 33243686) CNS Neurosci Ther. 2023 Feb;29(2):597-608. (PMID: 36468416) J Alzheimers Dis. 2019;70(1):107-120. (PMID: 31177210) Geroscience. 2023 Jun;45(3):1471-1490. (PMID: 36933144) Sci Rep. 2018 Apr 19;8(1):6264. (PMID: 29674739) Sci Rep. 2018 Jul 3;8(1):10024. (PMID: 29968786) Alzheimers Dement. 2020 Nov;16(11):1553-1560. (PMID: 31706733) Epilepsy Res. 2020 Nov;167:106449. (PMID: 32937221) J Neurosci. 2011 Mar 2;31(9):3261-70. (PMID: 21368038) Biomed Res Int. 2015;2015:810548. (PMID: 25918722) Neurology. 2015 May 12;84(19):1956-63. (PMID: 25878180) Proc Natl Acad Sci U S A. 2016 Oct 25;113(43):12286-12291. (PMID: 27791017) Hippocampus. 2014 Oct;24(10):1248-60. (PMID: 24888442) Behav Brain Res. 2019 May 17;364:431-441. (PMID: 29158112) J Alzheimers Dis. 2022;85(3):1267-1282. (PMID: 34924387) Neuroimage. 2017 May 15;152:437-449. (PMID: 28167349) Neuropeptides. 2015 Aug;52:1-18. (PMID: 26149638) Proc Natl Acad Sci U S A. 2016 Aug 2;113(31):E4541-7. (PMID: 27439860) Nat Rev Neurosci. 2009 Mar;10(3):186-98. (PMID: 19190637) Alzheimers Res Ther. 2012 Jan 10;4(1):2. (PMID: 22236691) J Neurosci. 2012 Jun 27;32(26):8890-9. (PMID: 22745490) Neurology. 2010 Jun 15;74(24):1969-76. (PMID: 20463288) Front Behav Neurosci. 2019 Oct 01;13:233. (PMID: 31632251) PLoS One. 2015 Mar 19;10(3):e0120345. (PMID: 25789862) Sci Rep. 2018 Nov 1;8(1):16153. (PMID: 30385825) Neurobiol Aging. 2023 Mar;123:98-110. (PMID: 36657371) Neuroradiol J. 2017 Aug;30(4):305-317. (PMID: 28353416) Clin Neurophysiol. 2014 Jul;125(7):1295-305. (PMID: 24831083) Magn Reson Med. 1995 Oct;34(4):537-41. (PMID: 8524021) J Neurosci. 2009 Oct 7;29(40):12686-94. (PMID: 19812343) Neurobiol Dis. 2019 Apr;124:93-107. (PMID: 30445024) J Alzheimers Dis. 2018;66(3):1223-1234. (PMID: 30412488) Nature. 2007 May 3;447(7140):83-6. (PMID: 17476267) Annu Rev Neurosci. 2018 Jul 8;41:277-297. (PMID: 29986165) iScience. 2020 Aug 12;23(9):101455. (PMID: 32846343) PLoS One. 2019 Jul 26;14(7):e0220061. (PMID: 31348798) Front Neural Circuits. 2021 Jan 22;14:612529. (PMID: 33551755) Neuroimage. 2022 Aug 15;257:119287. (PMID: 35594811) Heliyon. 2021 Sep 01;7(9):e07895. (PMID: 34568591) PLoS One. 2014 Sep 02;9(9):e106156. (PMID: 25181007) Brain Commun. 2022 Mar 25;4(2):fcac072. (PMID: 35434622) Biol Psychiatry. 2010 Mar 15;67(6):584-7. (PMID: 19833321) Neurobiol Aging. 2014 Apr;35(4):757-68. (PMID: 24216223) Front Aging Neurosci. 2019 Aug 08;11:213. (PMID: 31440158) Int J Alzheimers Dis. 2011;2011:535816. (PMID: 21760988) Hum Brain Mapp. 2002 Jan;15(1):1-25. (PMID: 11747097) Proc Natl Acad Sci U S A. 2014 Dec 30;111(52):18745-50. (PMID: 25512496) Neuroimage. 2019 Aug 15;197:167-176. (PMID: 31029872) Brain Sci. 2021 Sep 30;11(10):. (PMID: 34679365) Front Aging Neurosci. 2023 Mar 22;15:1081058. (PMID: 37032829) Prog Neuropsychopharmacol Biol Psychiatry. 2021 Dec 20;111:110346. (PMID: 33961964) Neuroscientist. 2017 Dec;23(6):616-626. (PMID: 28406055) Neurobiol Learn Mem. 2022 Mar;189:107601. (PMID: 35202816) Neurobiol Dis. 2018 Feb;110:166-179. (PMID: 29199135) Sci Rep. 2022 Nov 9;12(1):19129. (PMID: 36352024) Pharmacol Rep. 2015 Apr;67(2):195-203. (PMID: 25712639) Front Syst Neurosci. 2010 Jun 07;4:16. (PMID: 20589099) Neuroimage. 2022 Aug 1;256:119228. (PMID: 35452806) Neuroimage. 2018 May 15;172:9-20. (PMID: 29414498) Sci Rep. 2017 Apr 12;7:46427. (PMID: 28401931) Acta Neuropathol Commun. 2019 Nov 14;7(1):180. (PMID: 31727182) Neuroimage. 2006 Jun;31(2):496-504. (PMID: 16473024) Nature. 2004 Aug 5;430(7000):631-9. (PMID: 15295589) |
| معلومات مُعتمدة: | SAO-FRA-20180003 Internationale Stichting Alzheimer Onderzoek (ISAO); SAO-FRA-20180003 Internationale Stichting Alzheimer Onderzoek (ISAO) |
| تواريخ الأحداث: | Date Created: 20240620 Latest Revision: 20240623 |
| رمز التحديث: | 20240623 |
| مُعرف محوري في PubMed: | PMC11190202 |
| DOI: | 10.1038/s41514-024-00151-7 |
| PMID: | 38902224 |
| قاعدة البيانات: | MEDLINE |
Find this article in full text from Springer Verlag. | تدمد: | 2731-6068 |
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| DOI: | 10.1038/s41514-024-00151-7 |