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Is systemic inflammation a missing link between cardiometabolic index with mortality? Evidence from a large population-based study.

التفاصيل البيبلوغرافية
العنوان: Is systemic inflammation a missing link between cardiometabolic index with mortality? Evidence from a large population-based study.
المؤلفون: Xu B; Department of Cardiology, Shanghai Tenth People's Hospital, Tongji University School of Medicine, 301 Yanchang Road, Shanghai, 200072, China.; Department of Cardiology, Zhongshan-Xuhui Hospital, Shanghai Xuhui Central Hospital, Fudan University, Shanghai, China., Wu Q; Department of Orthopedic Surgery, Orthopedic Institute, The First Affiliated Hospital of Soochow University, 188 Shizijie Road, Suzhou, 215006, Jiangsu, China. qianwujoint@163.com.; Research Institute of Clinical Medicine, Jeonbuk National University Medical School, Jeonju, Republic of Korea. qianwujoint@163.com., La R; Department of Orthopedic Surgery, Orthopedic Institute, The First Affiliated Hospital of Soochow University, 188 Shizijie Road, Suzhou, 215006, Jiangsu, China., Lu L; Department of Pediatric Surgery and Rehabilitation, Kunshan Maternity and Children's Health Care Hospital, Kunshan, Jiangsu, China., Abdu FA; Department of Cardiology, Shanghai Tenth People's Hospital, Tongji University School of Medicine, 301 Yanchang Road, Shanghai, 200072, China., Yin G; Department of Cardiology, Shanghai Tenth People's Hospital, Tongji University School of Medicine, 301 Yanchang Road, Shanghai, 200072, China., Zhang W; Department of Cardiology, Shanghai Tenth People's Hospital, Tongji University School of Medicine, 301 Yanchang Road, Shanghai, 200072, China., Ding W; Department of Orthopedic Surgery, Orthopedic Institute, The First Affiliated Hospital of Soochow University, 188 Shizijie Road, Suzhou, 215006, Jiangsu, China., Ling Y; Department of Orthopedic Surgery, Orthopedic Institute, The First Affiliated Hospital of Soochow University, 188 Shizijie Road, Suzhou, 215006, Jiangsu, China., He Z; Department of Orthopedic Surgery, Orthopedic Institute, The First Affiliated Hospital of Soochow University, 188 Shizijie Road, Suzhou, 215006, Jiangsu, China., Che W; Department of Cardiology, Shanghai Tenth People's Hospital, Tongji University School of Medicine, 301 Yanchang Road, Shanghai, 200072, China. chewenliang@tongji.edu.cn.
المصدر: Cardiovascular diabetology [Cardiovasc Diabetol] 2024 Jun 20; Vol. 23 (1), pp. 212. Date of Electronic Publication: 2024 Jun 20.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: BioMed Central Country of Publication: England NLM ID: 101147637 Publication Model: Electronic Cited Medium: Internet ISSN: 1475-2840 (Electronic) Linking ISSN: 14752840 NLM ISO Abbreviation: Cardiovasc Diabetol Subsets: MEDLINE
أسماء مطبوعة: Original Publication: London : BioMed Central, [2002-
مواضيع طبية MeSH: Inflammation*/blood , Inflammation*/mortality , Inflammation*/diagnosis , Inflammation*/immunology , Nutrition Surveys* , Cardiovascular Diseases*/mortality , Cardiovascular Diseases*/diagnosis , Cardiovascular Diseases*/immunology , Cardiovascular Diseases*/blood , Cause of Death* , Cardiometabolic Risk Factors*, Humans ; Male ; Aged ; Female ; Risk Assessment ; United States/epidemiology ; Aged, 80 and over ; Time Factors ; Prognosis ; Inflammation Mediators/blood ; Age Factors ; Neutrophils/immunology ; Lymphocyte Count ; Biomarkers/blood
مستخلص: Background: This study sought to elucidate the associations of cardiometabolic index (CMI), as a metabolism-related index, with all-cause and cardiovascular mortality among the older population. Utilizing data from the National Health and Nutrition Examination Survey (NHANES), we further explored the potential mediating effect of inflammation within these associations.
Methods: A cohort of 3029 participants aged over 65 years old, spanning six NHANES cycles from 2005 to 2016, was enrolled and assessed. The primary endpoints of the study included all-cause mortality and cardiovascular mortality utilizing data from National Center for Health Statistics (NCHS). Cox regression model and subgroup analysis were conducted to assess the associations of CMI with all-cause and cardiovascular mortality. The mediating effect of inflammation-related indicators including leukocyte, neutrophil, lymphocyte, systemic immune-inflammation index (SII), neutrophil to lymphocyte ratio (NLR) were evaluated to investigate the potential mechanism of the associations between CMI and mortality through mediation package in R 4.2.2.
Results: The mean CMI among the enrolled participants was 0.74±0.66, with an average age of 73.28±5.50 years. After an average follow-up period of 89.20 months, there were 1,015 instances of all-cause deaths and 348 cardiovascular deaths documented. In the multivariable-adjusted model, CMI was positively related to all-cause mortality (Hazard Ratio (HR)=1.11, 95% CI=1.01-1.21). Mediation analysis indicated that leukocytes and neutrophils mediated 6.6% and 13.9% of the association of CMI with all-cause mortality.
Conclusion: Elevated CMI is positively associated with all-cause mortality in the older adults. The association appeared to be partially mediated through inflammatory pathways, indicating that CMI may serve as a valuable indicator for poor prognosis among the older population.
(© 2024. The Author(s).)
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معلومات مُعتمدة: 82170521 Chinese National Natural Science Foundation; 21ZR1449500 Shanghai Natural Science Foundation of China; 202140263 Foundation of Shanghai Municipal Health Commission; XZ2022ZR-ZY27(Z) Tibet Natural Science Foundation of China; CKY2021-21 Foundation of Chongming; YNCR2A001 Clinical Research Plan of Shanghai Tenth People?s Hospital; SHDC2020CR4065 Clinical Research Plan of SHDC; 20dz1207200 Foundation of the Science and Technology Commission of Shanghai Municipality
فهرسة مساهمة: Keywords: Cardiometabolic index; Cardiovascular disease; Inflammation; Mortality; National Health and Nutrition Examination Survey
المشرفين على المادة: 0 (Inflammation Mediators)
0 (Biomarkers)
تواريخ الأحداث: Date Created: 20240620 Date Completed: 20240621 Latest Revision: 20240623
رمز التحديث: 20240623
مُعرف محوري في PubMed: PMC11191290
DOI: 10.1186/s12933-024-02251-w
PMID: 38902748
قاعدة البيانات: MEDLINE
الوصف
تدمد:1475-2840
DOI:10.1186/s12933-024-02251-w