دورية أكاديمية
أعرض في EDS

Circ_0004851 regulates the molecular mechanism of miR-296-3p/FGF11 in the influence of high iodine on PTC.

التفاصيل البيبلوغرافية
العنوان: Circ_0004851 regulates the molecular mechanism of miR-296-3p/FGF11 in the influence of high iodine on PTC.
المؤلفون: Li JJ; Department of Endocrinology and Metabolism, The Second Affiliated Hospital of Harbin Medical University, Harbin, 150086, Heilongjiang, China., Ru ZX; Department of Endocrinology and Metabolism, The Second Affiliated Hospital of Harbin Medical University, Harbin, 150086, Heilongjiang, China., Yang X; Department of Endocrinology and Metabolism, The Second Affiliated Hospital of Harbin Medical University, Harbin, 150086, Heilongjiang, China., Sun JX; Department of Endocrinology and Metabolism, The Second Affiliated Hospital of Harbin Medical University, Harbin, 150086, Heilongjiang, China., Wu YM; Department of Endocrinology and Metabolism, The Second Affiliated Hospital of Harbin Medical University, Harbin, 150086, Heilongjiang, China., Yang XY; Department of Science and Education, Heilongjiang Provincial Hospital, Harbin, 150036, Heilongjiang, China., Hou BY; Department of Endocrinology and Metabolism, The Second Affiliated Hospital of Harbin Medical University, Harbin, 150086, Heilongjiang, China., Xue B; Department of Endocrinology and Metabolism, The Second Affiliated Hospital of Harbin Medical University, Harbin, 150086, Heilongjiang, China., Ding C; Department of General surgery, The Second Affiliated Hospital of Harbin Medical University, Harbin, 150086, Heilongjiang, China., Qiao H; Department of Endocrinology and Metabolism, The Second Affiliated Hospital of Harbin Medical University, Harbin, 150086, Heilongjiang, China. qiaohong@hrbmu.edu.cn.; NHC Key Laboratory of Etiology and Epidemiology, Harbin Medical University, No. 157 Baojian Road, Nangang District, Harbin, 150081, Heilongjiang, China. qiaohong@hrbmu.edu.cn.
المصدر: Journal of translational medicine [J Transl Med] 2024 Jun 20; Vol. 22 (1), pp. 586. Date of Electronic Publication: 2024 Jun 20.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: BioMed Central Country of Publication: England NLM ID: 101190741 Publication Model: Electronic Cited Medium: Internet ISSN: 1479-5876 (Electronic) Linking ISSN: 14795876 NLM ISO Abbreviation: J Transl Med Subsets: MEDLINE
أسماء مطبوعة: Original Publication: [London] : BioMed Central, 2003-
مواضيع طبية MeSH: MicroRNAs*/genetics , MicroRNAs*/metabolism , RNA, Circular*/genetics , RNA, Circular*/metabolism , Thyroid Cancer, Papillary*/genetics , Thyroid Cancer, Papillary*/pathology , Iodine*/metabolism , Gene Expression Regulation, Neoplastic*, Humans ; Cell Line, Tumor ; Thyroid Neoplasms/genetics ; Thyroid Neoplasms/pathology ; Base Sequence
مستخلص: The prevalence of papillary thyroid cancer (PTC) has been rising in recent years. Despite its relatively low mortality, PTC frequently metastasizes to lymph nodes and often recurs, posing significant health and economic burdens. The role of iodine in the pathogenesis and advancement of thyroid cancer remains poorly understood. Circular RNAs (circRNAs) are recognized to function as competing endogenous RNAs (ceRNAs) that modulate gene expression and play a role in various cancer stages. Consequently, this research aimed to elucidate the mechanism by which circRNA influences the impact of iodine on PTC. Our research indicates that high iodine levels can exacerbate the malignancy of PTC via the circ_0004851/miR-296-3p/FGF11 axis. These insights into iodine's biological role in PTC and the association of circRNA with the disease could pave the way for novel biomarkers and potentially effective therapeutic strategies to mitigate PTC progression.
(© 2024. The Author(s).)
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معلومات مُعتمدة: 82373698/82073491 National Natural Science Foundation of China; LH2021H062 Heilongjiang Provincial Natural Science Foundation of China; 2020-227 Heilongjiang Provincial Health Commission Foundation of China
فهرسة مساهمة: Keywords: Circ_0004851; FGF11; Iodine; PTC; Tumor development; miR-296-3p
المشرفين على المادة: 0 (MicroRNAs)
0 (RNA, Circular)
9679TC07X4 (Iodine)
0 (MIRN296 microRNA, human)
تواريخ الأحداث: Date Created: 20240620 Date Completed: 20240621 Latest Revision: 20240623
رمز التحديث: 20240623
مُعرف محوري في PubMed: PMC11191183
DOI: 10.1186/s12967-024-05405-2
PMID: 38902782
قاعدة البيانات: MEDLINE
الوصف
تدمد:1479-5876
DOI:10.1186/s12967-024-05405-2