دورية أكاديمية

Composite hydrogels with antioxidant and robust adhesive properties for the prevention of radiation-induced dermatitis.

التفاصيل البيبلوغرافية
العنوان: Composite hydrogels with antioxidant and robust adhesive properties for the prevention of radiation-induced dermatitis.
المؤلفون: Luo X; Research Center for Nano-Biomaterials, Analytical and Testing Center, Sichuan University, Chengdu, 610065, P. R. China. nic7504@scu.edu.cn., Liu H; Research Center for Nano-Biomaterials, Analytical and Testing Center, Sichuan University, Chengdu, 610065, P. R. China. nic7504@scu.edu.cn., Wen J; Research Center for Nano-Biomaterials, Analytical and Testing Center, Sichuan University, Chengdu, 610065, P. R. China. nic7504@scu.edu.cn., Hu J; Research Center for Nano-Biomaterials, Analytical and Testing Center, Sichuan University, Chengdu, 610065, P. R. China. nic7504@scu.edu.cn., Li Y; Research Center for Nano-Biomaterials, Analytical and Testing Center, Sichuan University, Chengdu, 610065, P. R. China. nic7504@scu.edu.cn., Li G; Department of Radiotherapy Physics & Technology, West China Hospital, Sichuan University, Chengdu, 610041, P. R. China., Dai G; Department of Radiotherapy Physics & Technology, West China Hospital, Sichuan University, Chengdu, 610041, P. R. China., Li Y; Research Center for Nano-Biomaterials, Analytical and Testing Center, Sichuan University, Chengdu, 610065, P. R. China. nic7504@scu.edu.cn., Li J; Research Center for Nano-Biomaterials, Analytical and Testing Center, Sichuan University, Chengdu, 610065, P. R. China. nic7504@scu.edu.cn.
المصدر: Journal of materials chemistry. B [J Mater Chem B] 2024 Jul 17; Vol. 12 (28), pp. 6927-6939. Date of Electronic Publication: 2024 Jul 17.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Royal Society of Chemistry Country of Publication: England NLM ID: 101598493 Publication Model: Electronic Cited Medium: Internet ISSN: 2050-7518 (Electronic) Linking ISSN: 2050750X NLM ISO Abbreviation: J Mater Chem B Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Cambridge : Royal Society of Chemistry
مواضيع طبية MeSH: Hydrogels*/chemistry , Hydrogels*/pharmacology , Antioxidants*/chemistry , Antioxidants*/pharmacology , Radiodermatitis*/prevention & control , Radiodermatitis*/drug therapy , Alginates*/chemistry , Alginates*/pharmacology, Animals ; Humans ; Acrylic Resins/chemistry ; Acrylic Resins/pharmacology ; Mice ; Molybdenum/chemistry ; Molybdenum/pharmacology ; Disulfides/chemistry ; Disulfides/pharmacology ; Reactive Oxygen Species/metabolism ; Adhesives/chemistry ; Adhesives/pharmacology ; Particle Size
مستخلص: Radiotherapy is a pivotal means of cancer treatment, but it often leads to radiation dermatitis, a skin injury caused by radiation-induced excess reactive oxygen species (ROS). Scavenging free radicals in the course of radiation therapy will be an effective means to prevent radiation dermatitis. This study demonstrates a novel double network hydrogel doped with MoS 2 nanosheets for the prevention of radiation-induced dermatitis. The resultant SPM hydrogel constructed from polyacrylamide (PAM) and sodium alginate (SA) nanofiber presented favorable mechanical and adhesion properties. It could conform well to the human body's irregular contours without secondary dressing fixation, making it suitable for skin protection applications. The in vitro and in vivo experiments showed that the antioxidant properties conferred by MoS 2 nanosheets enable SPM to effectively mitigate excessive ROS and reduce oxidative stress, thereby preventing radiation dermatitis caused by oxidative damage. Biosafety assessments indicated good biocompatibility of the composite hydrogel, suggesting SPM's practicality and potential as an external dressing for skin radiation protection.
المشرفين على المادة: 0 (Hydrogels)
0 (Antioxidants)
0 (Alginates)
0 (Acrylic Resins)
81AH48963U (Molybdenum)
0 (Disulfides)
ZC8B4P503V (molybdenum disulfide)
0 (Reactive Oxygen Species)
9003-05-8 (polyacrylamide)
0 (Adhesives)
تواريخ الأحداث: Date Created: 20240621 Date Completed: 20240717 Latest Revision: 20240717
رمز التحديث: 20240717
DOI: 10.1039/d4tb00511b
PMID: 38904166
قاعدة البيانات: MEDLINE
الوصف
تدمد:2050-7518
DOI:10.1039/d4tb00511b