دورية أكاديمية

Public neoantigens in breast cancer immunotherapy (Review).

التفاصيل البيبلوغرافية
العنوان: Public neoantigens in breast cancer immunotherapy (Review).
المؤلفون: Sueangoen N; Research Center, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok 10400, Thailand., Thuwajit P; Department of Immunology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok 10700, Thailand., Yenchitsomanus PT; Siriraj Center of Research Excellence for Cancer Immunotherapy (SiCORE‑CIT), Research Department, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok 10700, Thailand., Thuwajit C; Department of Immunology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok 10700, Thailand.
المصدر: International journal of molecular medicine [Int J Mol Med] 2024 Jul; Vol. 54 (1). Date of Electronic Publication: 2024 Jun 21.
نوع المنشور: Journal Article; Review
اللغة: English
بيانات الدورية: Publisher: D.A. Spandidos Country of Publication: Greece NLM ID: 9810955 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1791-244X (Electronic) Linking ISSN: 11073756 NLM ISO Abbreviation: Int J Mol Med Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Athens, Greece : D.A. Spandidos, [1998-
مواضيع طبية MeSH: Breast Neoplasms*/therapy , Breast Neoplasms*/immunology , Breast Neoplasms*/genetics , Antigens, Neoplasm*/immunology , Antigens, Neoplasm*/genetics , Immunotherapy*/methods, Humans ; Female ; Mutation
مستخلص: Among women globally, breast cancer is the most prevalent cancer and the leading cause of cancer‑related death. Interestingly, though genetic mutations contribute to the disease, <15% of women diagnosed with breast cancer have a family history of the disease, suggesting a prevalence of sporadic genetic mutations in breast cancer development. In the rapidly rising field of cancer genomics, neoantigen‑based immunotherapy has come to the fore. The investigation of novel proteins arising from unique somatic mutations or neoantigens have opened a new pathway for both individualized and public cancer treatments. Because they are shared among individuals with similar genetic changes, public neoantigens provide an opportunity for 'off‑the‑shelf' anticancer therapies, potentially extending the benefits to a wider patient group. The present review aimed to highlight the role of shared or public neoantigens as therapeutic targets for patients with breast cancer, emphasizing common hotspot mutations of certain genes identified in breast cancer. The clinical utilization of public neoantigen‑based therapies for breast cancer treatment were also discussed.
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فهرسة مساهمة: Keywords: breast cancer; hotspot mutation; immunotherapy; public neoantigen
المشرفين على المادة: 0 (Antigens, Neoplasm)
تواريخ الأحداث: Date Created: 20240621 Date Completed: 20240621 Latest Revision: 20240626
رمز التحديث: 20240627
مُعرف محوري في PubMed: PMC11188978
DOI: 10.3892/ijmm.2024.5388
PMID: 38904202
قاعدة البيانات: MEDLINE
الوصف
تدمد:1791-244X
DOI:10.3892/ijmm.2024.5388