دورية أكاديمية
A double whammy for KEAP1.
| العنوان: | A double whammy for KEAP1. |
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| المؤلفون: | Gerhartz J; Institute of Structural Biology, Medical Faculty, University of Bonn, Bonn, Germany., Nowak RP; Institute of Structural Biology, Medical Faculty, University of Bonn, Bonn, Germany. Electronic address: radoslaw.nowak@uni-bonn.de. |
| المصدر: | Cell chemical biology [Cell Chem Biol] 2024 Jun 20; Vol. 31 (6), pp. 1047-1049. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Cell Press Country of Publication: United States NLM ID: 101676030 Publication Model: Print Cited Medium: Internet ISSN: 2451-9448 (Electronic) Linking ISSN: 24519448 NLM ISO Abbreviation: Cell Chem Biol Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Cambridge, MA : Cell Press, 2016- |
| مواضيع طبية MeSH: | Kelch-Like ECH-Associated Protein 1*/metabolism , Kelch-Like ECH-Associated Protein 1*/antagonists & inhibitors , NF-E2-Related Factor 2*/metabolism , NF-E2-Related Factor 2*/antagonists & inhibitors, Animals ; Humans ; Inflammation/drug therapy ; Inflammation/metabolism ; Mice |
| مستخلص: | In this issue of Cell Chemical Biology, Lu et al. 1 report the discovery of a bivalent KEAP1 inhibitor (biKEAP1), which more rapidly activates NRF2 compared to previously reported monovalent KEAP1 inhibitors. biKEAP1suppresses acute inflammation in animal models. Competing Interests: Declaration of interests The authors declare no competing interests. (Copyright © 2024 Elsevier Ltd. All rights reserved.) |
| المشرفين على المادة: | 0 (Kelch-Like ECH-Associated Protein 1) 0 (NF-E2-Related Factor 2) 0 (KEAP1 protein, human) |
| تواريخ الأحداث: | Date Created: 20240621 Date Completed: 20240621 Latest Revision: 20240710 |
| رمز التحديث: | 20240710 |
| DOI: | 10.1016/j.chembiol.2024.05.014 |
| PMID: | 38906110 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 2451-9448 |
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| DOI: | 10.1016/j.chembiol.2024.05.014 |