دورية أكاديمية
N-acetyltransferase metabolism and DNA damage following exposure to 4,4'-oxydianiline in human bronchial epithelial cells.
| العنوان: | N-acetyltransferase metabolism and DNA damage following exposure to 4,4'-oxydianiline in human bronchial epithelial cells. |
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| المؤلفون: | Wise JTF; Department of Pharmacology and Toxicology, School of Medicine, University of Louisville, Louisville, KY 40202, USA; Wise Laboratory of Nutritional Toxicology and Metabolism, School of Nutrition and Food Sciences, Louisiana State University Agricultural Center, Baton Rouge, LA 70803, USA; School of Nutrition and Food Sciences, College of Agriculture, Louisiana State University, Baton Rouge, LA 70803, USA., Hein DW; Department of Pharmacology and Toxicology, School of Medicine, University of Louisville, Louisville, KY 40202, USA. Electronic address: david.hein@louisville.edu. |
| المصدر: | Toxicology letters [Toxicol Lett] 2024 Jul; Vol. 398, pp. 65-68. Date of Electronic Publication: 2024 Jun 19. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Country of Publication: Netherlands NLM ID: 7709027 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-3169 (Electronic) Linking ISSN: 03784274 NLM ISO Abbreviation: Toxicol Lett Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Amsterdam : Elsevier Original Publication: Amsterdam, Elsevier/North Holland. |
| مواضيع طبية MeSH: | DNA Damage* , Bronchi*/drug effects , Bronchi*/cytology , Bronchi*/metabolism , Epithelial Cells*/drug effects , Epithelial Cells*/metabolism , Arylamine N-Acetyltransferase*/genetics , Arylamine N-Acetyltransferase*/metabolism, Humans ; Acetylation ; Cell Line ; Smoke/adverse effects ; Isoenzymes |
| مستخلص: | Waterpipe smoking is increasingly popular and understanding how chemicals found in hookah smoke may be harmful to human bronchial epithelial cells is of great importance. 4,4'-Oxydianiline (ODA), is an aromatic amine which is present at comparatively high levels in hookah smoke. The metabolism and the subsequent toxicity of ODA in human bronchial epithelial cells remains unknown. Given that ODA is an aromatic amine, we hypothesized that ODA is N-acetylated and induces DNA damage following exposure to immortalized human bronchial epithelial cells (BEP2D cells). We measured the N-acetylation of ODA to mono-acetyl-ODA and the N-acetylation of mono-acetyl-ODA to diacetyl-ODA by BEP2D cells following separation and quantitation by high performance liquid chromatography. For ODA, the apparent K Competing Interests: Declaration of Competing Interest The authors declare the following financial interests/personal relationships which may be considered as potential competing interests: David W. Hein reports financial support was provided by National Institutes of Health. David W. Hein reports a relationship with Catalyst Pharmaceuticals Inc that includes: consulting or advisory. If there are other authors, they declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. (Copyright © 2024 Elsevier B.V. All rights reserved.) |
| معلومات مُعتمدة: | T32 ES011564 United States ES NIEHS NIH HHS |
| فهرسة مساهمة: | Keywords: 4,4’-Oxydianiline; DNA damage; Hookah smoke; Human bronchial epithelial cells; N-acetylation; Waterpipe |
| المشرفين على المادة: | EC 2.3.1.5 (Arylamine N-Acetyltransferase) EC 2.3.1.5 (NAT2 protein, human) EC 2.3.1.5 (N-acetyltransferase 1) 0 (Smoke) 0 (Isoenzymes) |
| تواريخ الأحداث: | Date Created: 20240621 Date Completed: 20240718 Latest Revision: 20240718 |
| رمز التحديث: | 20240719 |
| DOI: | 10.1016/j.toxlet.2024.06.005 |
| PMID: | 38906436 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1879-3169 |
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| DOI: | 10.1016/j.toxlet.2024.06.005 |