دورية أكاديمية
N-acetyltransferase metabolism and DNA damage following exposure to 4,4'-oxydianiline in human bronchial epithelial cells.
| العنوان: | N-acetyltransferase metabolism and DNA damage following exposure to 4,4'-oxydianiline in human bronchial epithelial cells. |
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| المؤلفون: | Wise JTF; Department of Pharmacology and Toxicology, School of Medicine, University of Louisville, Louisville, KY 40202, USA; Wise Laboratory of Nutritional Toxicology and Metabolism, School of Nutrition and Food Sciences, Louisiana State University Agricultural Center, Baton Rouge, LA 70803, USA; School of Nutrition and Food Sciences, College of Agriculture, Louisiana State University, Baton Rouge, LA 70803, USA., Hein DW; Department of Pharmacology and Toxicology, School of Medicine, University of Louisville, Louisville, KY 40202, USA. Electronic address: david.hein@louisville.edu. |
| المصدر: | Toxicology letters [Toxicol Lett] 2024 Jul; Vol. 398, pp. 65-68. Date of Electronic Publication: 2024 Jun 19. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Country of Publication: Netherlands NLM ID: 7709027 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-3169 (Electronic) Linking ISSN: 03784274 NLM ISO Abbreviation: Toxicol Lett Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Amsterdam : Elsevier Original Publication: Amsterdam, Elsevier/North Holland. |
| مواضيع طبية MeSH: | DNA Damage* , Bronchi*/drug effects , Bronchi*/cytology , Bronchi*/metabolism , Epithelial Cells*/drug effects , Epithelial Cells*/metabolism , Arylamine N-Acetyltransferase*/genetics , Arylamine N-Acetyltransferase*/metabolism, Humans ; Acetylation ; Cell Line ; Smoke/adverse effects ; Isoenzymes |
| مستخلص: | Waterpipe smoking is increasingly popular and understanding how chemicals found in hookah smoke may be harmful to human bronchial epithelial cells is of great importance. 4,4'-Oxydianiline (ODA), is an aromatic amine which is present at comparatively high levels in hookah smoke. The metabolism and the subsequent toxicity of ODA in human bronchial epithelial cells remains unknown. Given that ODA is an aromatic amine, we hypothesized that ODA is N-acetylated and induces DNA damage following exposure to immortalized human bronchial epithelial cells (BEP2D cells). We measured the N-acetylation of ODA to mono-acetyl-ODA and the N-acetylation of mono-acetyl-ODA to diacetyl-ODA by BEP2D cells following separation and quantitation by high performance liquid chromatography. For ODA, the apparent K Competing Interests: Declaration of Competing Interest The authors declare the following financial interests/personal relationships which may be considered as potential competing interests: David W. Hein reports financial support was provided by National Institutes of Health. David W. Hein reports a relationship with Catalyst Pharmaceuticals Inc that includes: consulting or advisory. If there are other authors, they declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. (Copyright © 2024 Elsevier B.V. All rights reserved.) |
| References: | JTO Clin Res Rep. 2021 May 08;2(7):100181. (PMID: 34790904) Food Chem Toxicol. 2008 May;46(5):1582-90. (PMID: 18308445) Pharmacol Ther. 2019 Aug;200:179-189. (PMID: 31075357) Toxicol Appl Pharmacol. 2022 Aug 15;449:116095. (PMID: 35662664) Int J Epidemiol. 2017 Feb 1;46(1):32-43. (PMID: 27075769) Tob Control. 2015 Mar;24 Suppl 1:i3-i12. (PMID: 25298368) Am J Health Behav. 2010 May-Jun;34(3):275-85. (PMID: 20001185) Nicotine Tob Res. 2007 Oct;9(10):987-94. (PMID: 17943617) Circulation. 2019 May 7;139(19):e917-e936. (PMID: 30845826) Toxicol Appl Pharmacol. 2009 May 1;236(3):366-71. (PMID: 19248797) BMC Pulm Med. 2017 Apr 21;17(1):68. (PMID: 28431548) Toxicol Appl Pharmacol. 2022 May 1;442:115993. (PMID: 35353990) DNA Repair (Amst). 2021 Dec;108:103243. (PMID: 34710661) Nicotine Tob Res. 2014 Apr;16(4):496-9. (PMID: 24302635) Toxicol Lett. 2010 Feb 1;192(2):221-8. (PMID: 19879933) Environ Mol Mutagen. 1988;11 Suppl 12:1-157. (PMID: 3277844) MMWR Morb Mortal Wkly Rep. 2018 Dec 14;67(49):1353-1357. (PMID: 30543601) Food Chem Toxicol. 2003 Jan;41(1):143-52. (PMID: 12453738) Food Chem Toxicol. 2005 May;43(5):655-61. (PMID: 15778004) J Natl Cancer Inst. 2000 Jan 19;92(2):106-11. (PMID: 10639511) Toxicol Lett. 2010 Nov 30;199(2):182-92. (PMID: 20832459) Toxicol Lett. 2019 Oct 1;313:60-65. (PMID: 31226396) Cancer Res. 1991 Oct 1;51(19):5370-7. (PMID: 1717149) Prev Chronic Dis. 2016 Feb 18;13:E24. (PMID: 26890407) J Chromatogr A. 2011 Aug 19;1218(33):5628-37. (PMID: 21752381) Drug Alcohol Depend. 2019 Jul 1;200:19-25. (PMID: 31071495) Environ Mol Mutagen. 1989;13(2):133-93. (PMID: 2917552) Tob Control. 2020 Feb;29(Suppl 2):s59-s61. (PMID: 31767787) |
| معلومات مُعتمدة: | P20 GM113226 United States GM NIGMS NIH HHS; P30 ES030283 United States ES NIEHS NIH HHS; P42 ES023716 United States ES NIEHS NIH HHS; T32 ES011564 United States ES NIEHS NIH HHS |
| فهرسة مساهمة: | Keywords: 4,4’-Oxydianiline; DNA damage; Hookah smoke; Human bronchial epithelial cells; N-acetylation; Waterpipe |
| المشرفين على المادة: | EC 2.3.1.5 (Arylamine N-Acetyltransferase) EC 2.3.1.5 (NAT2 protein, human) EC 2.3.1.5 (N-acetyltransferase 1) 0 (Smoke) 0 (Isoenzymes) |
| تواريخ الأحداث: | Date Created: 20240621 Date Completed: 20240718 Latest Revision: 20240819 |
| رمز التحديث: | 20240819 |
| مُعرف محوري في PubMed: | PMC11299505 |
| DOI: | 10.1016/j.toxlet.2024.06.005 |
| PMID: | 38906436 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1879-3169 |
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| DOI: | 10.1016/j.toxlet.2024.06.005 |