دورية أكاديمية
أعرض في EDS

Clinical characteristics and phylogenetic analysis of human enteric adenovirus type 41 (HAdV-F41) from children with gastroenteritis during SARS-CoV-2 pandemic.

التفاصيل البيبلوغرافية
العنوان: Clinical characteristics and phylogenetic analysis of human enteric adenovirus type 41 (HAdV-F41) from children with gastroenteritis during SARS-CoV-2 pandemic.
المؤلفون: Bai R; Department of Clinical Laboratory, Guangdong Women and Children Hospital, Guangzhou 511443, China; The Guangdong Second Provincial General Hospital, Guangzhou, China., Chen Y; Department of Clinical Laboratory, Guangdong Women and Children Hospital, Guangzhou 511443, China., Ou J; Key Laboratory of Viral Pathogenesis & Infection Prevention and Control (Jinan University), Ministry of Education, Institute of Medical Microbiology, College of Life Science and Technology, Jinan University, Guangzhou 510632, China., Dong W; Department of Clinical Laboratory, Guangdong Women and Children Hospital, Guangzhou 511443, China., Zhong T; Department of Clinical Laboratory, Guangdong Women and Children Hospital, Guangzhou 511443, China., Li Y; Key Laboratory of Viral Pathogenesis & Infection Prevention and Control (Jinan University), Ministry of Education, Institute of Medical Microbiology, College of Life Science and Technology, Jinan University, Guangzhou 510632, China., Li C; Biosafety Laboratory, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou 510080, China., Liu C; Department of Clinical Laboratory, Guangdong Women and Children Hospital, Guangzhou 511443, China., Ji C; Department of Clinical Laboratory, Guangdong Women and Children Hospital, Guangzhou 511443, China., Li H; Department of Clinical Laboratory, Guangdong Women and Children Hospital, Guangzhou 511443, China., Luo Y; Department of Clinical Laboratory, Guangdong Women and Children Hospital, Guangzhou 511443, China., Mei YF; Department of Clinical Microbiology, Section of Virology, Umeå University, SE-90185 Umeå, Sweden., Wu J; Guangdong Center for Disease Control and Prevention, Guangzhou, China., Seto D; Bioinformatics and Computational Biology Program, School of Systems Biology, George Mason University, Manassas, VA, USA., Yin A; Department of Clinical Laboratory, Guangdong Women and Children Hospital, Guangzhou 511443, China; Medical Genetic Center, Guangdong Women and Children Hospital, Guangzhou 511443, China. Electronic address: yinaiwa@vip.126.com., Zhang Q; Key Laboratory of Viral Pathogenesis & Infection Prevention and Control (Jinan University), Ministry of Education, Institute of Medical Microbiology, College of Life Science and Technology, Jinan University, Guangzhou 510632, China. Electronic address: zhangqw@jnu.edu.cn., Luo M; Department of Clinical Laboratory, Guangdong Women and Children Hospital, Guangzhou 511443, China. Electronic address: luo-my@163.com.
المصدر: Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases [Infect Genet Evol] 2024 Sep; Vol. 123, pp. 105619. Date of Electronic Publication: 2024 Jun 19.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Elsevier Science Country of Publication: Netherlands NLM ID: 101084138 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1567-7257 (Electronic) Linking ISSN: 15671348 NLM ISO Abbreviation: Infect Genet Evol Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Amsterdam ; New York : Elsevier Science, c2001-
مواضيع طبية MeSH: Gastroenteritis*/virology , Gastroenteritis*/epidemiology , Phylogeny* , COVID-19*/epidemiology , COVID-19*/virology , Adenoviruses, Human*/genetics , Adenoviruses, Human*/classification , Adenoviruses, Human*/isolation & purification , SARS-CoV-2*/genetics, Humans ; Child, Preschool ; Child ; China/epidemiology ; Infant ; Female ; Male ; Adenovirus Infections, Human/virology ; Adenovirus Infections, Human/epidemiology ; Prevalence
مستخلص: Human adenovirus type 41 (HAdV-F41) usually causes pediatrics gastroenteritis. However, it was reported to be associated with the outbreaks of severe acute hepatitis of unknown aetiology (SAHUA) in pediatrics during COVID-19 pandemic. In this study, we investigated the prevalence of enteric HAdV-F41 in 37,920 paediatric gastroenteritis cases from 2017 to 2022 in Guangzhou, China. All children presented were tested negative for SARS-CoV-2 during the "zero-COVID" period. The main clinical symptom of the children was diarrhea (96.5%). No fatalities nor liver abnormal symptoms was found. In 2021, one year since the pandemic of COVID-19, the prevalence of HAdV-F41 abruptly increased from 3.71% to 8.64% (P < 0.001). All of HAdV-F41 circulating worldwide were classified into eight different subtypes (G1-G8) based on the phylogenetic clustering permutation of the four capsid genes of HAdV-F41. G3 was the predominant subtype (56.2%; 77/137). CRV5 isolates from SAHUA cases belong to this subtype, in which N312D and H335D mutations in the short fiber knob were identified in both Guangzhou and CRV5 isolates, presumably changing the virus tropism by directly interacting with the heparin sulfate (HS) receptor. Additionally, a novel recombinant G6 subtype, which is unique and only circulating in China was first identified in this study. This is the first study highlighting the prevalence of HAdV-F41 in paediatric cases of gastroenteritis during COVID-19 pandemic in China. The clinical and viral evolution finding of HAdV-F41 provide insight into the clinical characteristics of children with HAdV-F41 infections as well as the uncertain role of HAdV-F41 in the cause of SAHUA.
Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2024 The Authors. Published by Elsevier B.V. All rights reserved.)
فهرسة مساهمة: Keywords: Clinical characteristics; Evolution; Genome; HAdV-F41; Recombination; Severe acute hepatitis of unknown aetiology (SAHUA); Subtype
تواريخ الأحداث: Date Created: 20240621 Date Completed: 20240828 Latest Revision: 20240828
رمز التحديث: 20240830
DOI: 10.1016/j.meegid.2024.105619
PMID: 38906518
قاعدة البيانات: MEDLINE
الوصف
تدمد:1567-7257
DOI:10.1016/j.meegid.2024.105619