دورية أكاديمية
أعرض في EDS

Sex, racial, ethnic, and geographical disparities in major adverse cardiovascular outcome of glucagon-like peptide-1 receptor agonists among patients with and without diabetes mellitus: A meta-analysis of placebo-controlled randomized controlled trials.

التفاصيل البيبلوغرافية
العنوان: Sex, racial, ethnic, and geographical disparities in major adverse cardiovascular outcome of glucagon-like peptide-1 receptor agonists among patients with and without diabetes mellitus: A meta-analysis of placebo-controlled randomized controlled trials.
المؤلفون: Rivera FB; Department of Medicine, Lincoln Medical Center, New York, NY, USA (Dr Rivera)., Bantayan NRB; University of the Philippines College of Medicine, Manila, Philippines (Drs Bantayan and Cruz)., Aparece JP; Department of Medicine, Texas Tech University Health Sciences Center, El Paso, TX, USA (Drs Aparece and Magallong)., Cruz LLA; University of the Philippines College of Medicine, Manila, Philippines (Drs Bantayan and Cruz)., Magallong JV; Department of Medicine, Texas Tech University Health Sciences Center, El Paso, TX, USA (Drs Aparece and Magallong)., Pine PL; AteneoSchool of Medicine and Public Health, Pasig, Philippines (Drs Pine and Idian-Javier)., Idian-Javier AMN; AteneoSchool of Medicine and Public Health, Pasig, Philippines (Drs Pine and Idian-Javier)., Lumbang GNO; Department of Medicine, Cebu Institute of Medicine, Cebu, Philippines (Dr Lumbang)., Lerma EV; Section of Nephrology, University of Illinois at Chicago College of Medicine, Chicago, Illinois, USA (Dr Lerma)., Lara-Breitinger KM; Department of Cardiovascular Medicine, Mayo Clinic, Rochester, Minnesota, (MN), USA (Dr Lara-Breitinger)., Gulati M; Department of Cardiology, Barbra Streisand Women's Heart Center, Cedars-Sinai Smidt Heart Institute, Los Angeles, CA, USA (Dr Gulati)., Vijayaraghavan K; University of Arizona, Phoenix, (AZ), USA. Electronic address: kvijaymd@gmail.com.
المصدر: Journal of clinical lipidology [J Clin Lipidol] 2024 Jul-Aug; Vol. 18 (4), pp. e588-e601. Date of Electronic Publication: 2024 Apr 04.
نوع المنشور: Journal Article; Meta-Analysis
اللغة: English
بيانات الدورية: Publisher: Elsevier Country of Publication: United States NLM ID: 101300157 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1933-2874 (Print) Linking ISSN: 18764789 NLM ISO Abbreviation: J Clin Lipidol Subsets: MEDLINE
أسماء مطبوعة: Original Publication: New York, NY : Elsevier
مواضيع طبية MeSH: Glucagon-Like Peptide-1 Receptor*/agonists , Randomized Controlled Trials as Topic* , Cardiovascular Diseases*/drug therapy , Diabetes Mellitus, Type 2*/drug therapy, Humans ; Female ; Racial Groups/statistics & numerical data ; Male ; Ethnicity/statistics & numerical data ; Sex Factors ; Hypoglycemic Agents/therapeutic use ; Geography ; Glucagon-Like Peptide-1 Receptor Agonists
مستخلص: Background: Glucagon-like peptide-1 receptor agonists (GLP-1RAs) have been pivotal in the management of type 2 diabetes mellitus (T2DM) and in the reduction of major adverse cardiovascular events (MACE). Notably, large cardiovascular outcomes trials (CVOTs) demonstrate significant disparities in inclusion, based on sex, race, ethnicity, and geographical regions.
Objectives: We examined the impact of GLP-1RA on MACE in patients with or without T2DM, based on sex, race, ethnicity, and geography.
Methods: A literature search for placebo controlled randomized controlled trials on GLP-1RA treatment was conducted. Thorough data extraction and quality assessment were carried out, focusing on key outcome, and ensuring a robust statistical analysis using a random effects model to calculate log odds ratio (OR) with 95% confidence intervals (CIs).
Results: A total of 8 CVOTs comprising 71,616 patients were included. Compared with placebo, GLP-1RAs significantly reduced MACE in both sexes (females: logOR -0.19, (95% CI, -0.28 to -0.10), p < 0.01) versus (males: logOR -0.17, (95% CI, -0.23 to -0.10), p < 0.01), (p interaction NS), and among Asians (logOR -34 (95% CI, -0.53 to -0.15), p < 0.01), and Whites (logOR -17 (95% CI, -0.25 to -0.09), p < 0.01), with no difference in MACE among Blacks and Hispanics. Odds of MACE were also reduced in Asia (logOR -31 (95% CI, -0.50 to -0.11), p < 0.01), and Europe (logOR -27 (95% CI, -0.40 to -0.13), p < 0.01), but there was no statistical difference in MACE in North America and Latin America.
Conclusion: Significant reductions in MACE with GLP-1RA treatment were demonstrated between both sexes and across certain ethnicities and certain geographical regions.
Competing Interests: Declaration of competing interest The authors declare that they have no conflicts of interest relevant to the content of this manuscript.
(Copyright © 2024. Published by Elsevier Inc.)
فهرسة مساهمة: Keywords: Cardiovascular outcomes; Disparities; Ethnic; GLP-1RA; Geographic; Glucagon-like peptide 1 receptor agonists; MACE; Sex
المشرفين على المادة: 0 (Glucagon-Like Peptide-1 Receptor)
0 (Hypoglycemic Agents)
0 (Glucagon-Like Peptide-1 Receptor Agonists)
تواريخ الأحداث: Date Created: 20240621 Date Completed: 20240831 Latest Revision: 20240831
رمز التحديث: 20240901
DOI: 10.1016/j.jacl.2024.03.011
PMID: 38906751
قاعدة البيانات: MEDLINE
الوصف
تدمد:1933-2874
DOI:10.1016/j.jacl.2024.03.011