دورية أكاديمية
أعرض في EDS

Utility of plasma anti-gSG6-P1 IgG levels in determining changes in Anopheles gambiae bite rates in a rural area of Cameroon.

التفاصيل البيبلوغرافية
العنوان: Utility of plasma anti-gSG6-P1 IgG levels in determining changes in Anopheles gambiae bite rates in a rural area of Cameroon.
المؤلفون: Nguetsa GC; Malaria Research Unit, Centre Pasteur Cameroon, P.O. Box 1274, Yaoundé, Cameroon. glwadys2011@gmail.com.; Department of Microbiology and Parasitology, Faculty of Sciences, The University of Buea, P.O. Box 63, Buea, Cameroon. glwadys2011@gmail.com., Elanga-Ndille E; Department of Animal Biology, Faculty of Sciences, The University of Dschang, P.O. Box 96, Dschang, Cameroon.; Department of Medical Entomology, Centre for Research in Infectious Diseases, P.O. Box 13591, Yaoundé, Cameroon., Essangui Same EG; Malaria Research Unit, Centre Pasteur Cameroon, P.O. Box 1274, Yaoundé, Cameroon.; Department of Biological Sciences, Faculty of Medicine and Pharmaceutical Sciences, The University of Douala, P.O. Box 2701, Douala, Cameroon., Nganso Keptchouang T; Malaria Research Unit, Centre Pasteur Cameroon, P.O. Box 1274, Yaoundé, Cameroon.; Department of Biological Sciences, Faculty of Medicine and Pharmaceutical Sciences, The University of Douala, P.O. Box 2701, Douala, Cameroon., Mandeng SE; Department of Animal Biology and Physiology, Faculty of Sciences, The University of Yaoundé, P.O. Box 337, Yaounde 1, Cameroon.; Laboratoire de Recherche sur le Paludisme, Organisation de Coordination pour la lutte Contre les Endémies en Afrique Centrale (OCEAC), P.O. Box 288, Yaoundé, Cameroon., Ekoko Eyisap W; Laboratoire de Recherche sur le Paludisme, Organisation de Coordination pour la lutte Contre les Endémies en Afrique Centrale (OCEAC), P.O. Box 288, Yaoundé, Cameroon., Binyang JA; Department of Medical Entomology, Centre for Research in Infectious Diseases, P.O. Box 13591, Yaoundé, Cameroon.; Department of Animal Biology and Physiology, Faculty of Sciences, The University of Yaoundé, P.O. Box 337, Yaounde 1, Cameroon., Fogang B; Malaria Research Unit, Centre Pasteur Cameroon, P.O. Box 1274, Yaoundé, Cameroon.; Department of Animal Biology and Physiology, Faculty of Sciences, The University of Yaoundé, P.O. Box 337, Yaounde 1, Cameroon., Nouage L; Department of Medical Entomology, Centre for Research in Infectious Diseases, P.O. Box 13591, Yaoundé, Cameroon.; Department of Animal Biology and Physiology, Faculty of Sciences, The University of Yaoundé, P.O. Box 337, Yaounde 1, Cameroon., Piameu M; Laboratoire de Recherche sur le Paludisme, Organisation de Coordination pour la lutte Contre les Endémies en Afrique Centrale (OCEAC), P.O. Box 288, Yaoundé, Cameroon.; Ecole des Sciences de La Santé, Université Catholique d'Afrique Centrale, P.O. Box 1110, Yaoundé, Cameroon., Ayong L; Malaria Research Unit, Centre Pasteur Cameroon, P.O. Box 1274, Yaoundé, Cameroon., Etang J; Department of Biological Sciences, Faculty of Medicine and Pharmaceutical Sciences, The University of Douala, P.O. Box 2701, Douala, Cameroon.; Laboratoire de Recherche sur le Paludisme, Organisation de Coordination pour la lutte Contre les Endémies en Afrique Centrale (OCEAC), P.O. Box 288, Yaoundé, Cameroon., Wanji S; Department of Microbiology and Parasitology, Faculty of Sciences, The University of Buea, P.O. Box 63, Buea, Cameroon., Eboumbou Moukoko CE; Malaria Research Unit, Centre Pasteur Cameroon, P.O. Box 1274, Yaoundé, Cameroon. elsecarole@yahoo.fr.; Department of Biological Sciences, Faculty of Medicine and Pharmaceutical Sciences, The University of Douala, P.O. Box 2701, Douala, Cameroon. elsecarole@yahoo.fr.; Laboratory of Parasitology, Mycology and Virology, Postgraduate Training Unit for Health Sciences, Postgraduate School for Pure and Applied Sciences, The University of Douala, P.O. Box 2701, Douala, Cameroon. elsecarole@yahoo.fr.
المصدر: Scientific reports [Sci Rep] 2024 Jun 21; Vol. 14 (1), pp. 14294. Date of Electronic Publication: 2024 Jun 21.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE
أسماء مطبوعة: Original Publication: London : Nature Publishing Group, copyright 2011-
مواضيع طبية MeSH: Anopheles*/parasitology , Anopheles*/immunology , Immunoglobulin G*/blood , Immunoglobulin G*/immunology , Insect Bites and Stings*/immunology , Insect Bites and Stings*/epidemiology , Insect Bites and Stings*/blood , Salivary Proteins and Peptides*/immunology, Adolescent ; Adult ; Animals ; Child ; Child, Preschool ; Female ; Humans ; Male ; Middle Aged ; Young Adult ; Cameroon/epidemiology ; Insect Proteins/immunology ; Malaria/epidemiology ; Malaria/immunology ; Malaria/blood ; Malaria/transmission ; Mosquito Vectors/parasitology ; Mosquito Vectors/immunology ; Rural Population ; Seasons
مستخلص: The applicability of the specific human IgG antibody response to Anopheles gambiae salivary Gland Protein-6 peptide 1 (gSG6-P1 salivary peptide) as a biomarker able to distinguish the level of exposure to mosquito bites according to seasonal variations has not yet been evaluated in Central African regions. The study aimed to provide the first reliable data on the IgG anti-gSG6-P1 response in rural area in Cameroon according to the dry- and rainy-season. Between May and December 2020, dry blood samples were collected from people living in the Bankeng village in the forest area of the Centre region of Cameroon. Malaria infection was determined by thick-blood smear microscopy and multiplex PCR. The level of IgG anti-gSG6-P1 response, was assessed by enzyme-linked immunosorbent assay. Anopheles density and aggressiveness were assessed using human landing catches. The prevalence of malaria infection remains significantly higher in the rainy season than in the dry season (77.57% vs 61.44%; p = 0.0001). The specific anti-gSG6-P1 IgG response could be detected in individuals exposed to few mosquito bites and showed inter-individual heterogeneity even when living in the same exposure area. In both seasons, the level of anti-gSG6-P1 IgG response was not significantly different between Plasmodium infected and non-infected individuals. Mosquito bites were more aggressive in the rainy season compared to the dry season (human biting rate-HBR of 15.05 b/p/n vs 1.5 b/p/n) where mosquito density was very low. Infected mosquitoes were found only during the rainy season (sporozoite rate = 10.63% and entomological inoculation rate-EIR = 1.42 ib/p/n). The level of IgG anti-gSG6-P1 response was significantly higher in the rainy season and correlated with HBR (p ˂ 0.0001). This study highlights the high heterogeneity of individual's exposure to the Anopheles gambiae s.l vector bites depending on the transmission season in the same area. These findings reinforce the usefulness of the anti-gSG6-P1 IgG response as an accurate immunological biomarker for detecting individual exposure to Anopheles gambiae s.l. bites during the low risk period of malaria transmission in rural areas and for the differentiating the level of exposure to mosquitoes.
(© 2024. The Author(s).)
References: Parasite. 2020;27:10. (PMID: 32048986)
PLoS One. 2016 Jul 21;11(7):e0159160. (PMID: 27441839)
Nat Rev Microbiol. 2005 Jan;3(1):81-90. (PMID: 15608702)
Am J Trop Med Hyg. 1987 Jul;37(1):37-41. (PMID: 2886070)
PLoS One. 2020 Dec 31;15(12):e0242510. (PMID: 33382730)
Int J Epidemiol. 2013 Feb;42(1):235-47. (PMID: 23396849)
Trans R Soc Trop Med Hyg. 1985;79(2):181-4. (PMID: 3890280)
Am J Trop Med Hyg. 1984 Sep;33(5):783-8. (PMID: 6385740)
PLoS One. 2013 Jun 20;8(6):e66354. (PMID: 23840448)
Am J Trop Med Hyg. 2018 May;98(5):1353-1359. (PMID: 29512479)
Malar J. 2010 Jun 16;9:169. (PMID: 20553604)
Malar J. 2012 Sep 10;11:318. (PMID: 22963464)
Malar J. 2011 Aug 31;10:253. (PMID: 21880138)
Sci Rep. 2021 Aug 4;11(1):15781. (PMID: 34349141)
PLoS One. 2010 Dec 14;5(12):e15596. (PMID: 21179476)
Am J Trop Med Hyg. 2018 Aug;99(2):350-356. (PMID: 29869601)
J Parasitol Res. 2021 Feb 02;2021:8848091. (PMID: 33623716)
Malar J. 2017 Jan 17;16(1):31. (PMID: 28095873)
Am J Trop Med Hyg. 2010 Jul;83(1):115-21. (PMID: 20595489)
Open Forum Infect Dis. 2020 Dec 30;8(2):ofaa635. (PMID: 33553475)
Insects. 2020 May 15;11(5):. (PMID: 32429075)
PLoS One. 2008 Jun 25;3(6):e2472. (PMID: 18575604)
Malar J. 2012 Mar 16;11:72. (PMID: 22424570)
Malar J. 2019 Mar 11;18(1):68. (PMID: 30857543)
Genes (Basel). 2019 Oct 11;10(10):. (PMID: 31614683)
Malar J. 2009 Aug 13;8:198. (PMID: 19674487)
Malar J. 2010 May 12;9:122. (PMID: 20459850)
Malar J. 2013 Aug 30;12:301. (PMID: 23988032)
J Infect Dis. 2017 Feb 1;215(3):396-404. (PMID: 27932615)
Trans R Soc Trop Med Hyg. 2000 Mar-Apr;94(2):113-27. (PMID: 10897348)
Am J Trop Med Hyg. 2004 Aug;71(2 Suppl):80-6. (PMID: 15331822)
PLoS One. 2022 Nov 10;17(11):e0276991. (PMID: 36355922)
Parasit Vectors. 2015 Oct 13;8:533. (PMID: 26464073)
PLoS Med. 2017 Feb 21;14(2):e1002234. (PMID: 28222094)
Med Vet Entomol. 2002 Dec;16(4):461-4. (PMID: 12510902)
Am J Epidemiol. 1990 Jul;132(1):58-66. (PMID: 2356814)
Lancet Planet Health. 2022 Mar;6(3):e257-e269. (PMID: 35278391)
Parasit Vectors. 2012 Apr 28;5:86. (PMID: 22541138)
Parasit Vectors. 2013 Mar 15;6:68. (PMID: 23497646)
Trop Med Int Health. 2010 Oct;15(10):1198-203. (PMID: 20723184)
Ann Trop Med Parasitol. 2003 Mar;97(2):131-7. (PMID: 12803868)
Asian Pac J Trop Med. 2017 Mar;10(3):299-304. (PMID: 28442114)
Mem Inst Oswaldo Cruz. 2014 Aug;109(5):685-705. (PMID: 25185008)
J Infect Dis. 2005 May 15;191(10):1589-98. (PMID: 15838785)
Am J Trop Med Hyg. 2003 Jun;68(6):734-42. (PMID: 12887036)
J Med Entomol. 2010 Nov;47(6):1156-63. (PMID: 21175067)
فهرسة مساهمة: Keywords: Anti-gSG6-P1 IgG response; Cameroon; Human biting rate; Mosquito density; Mosquito infection rates; Rural area; Seasonal transmission
المشرفين على المادة: 0 (gSG6-P1 peptide, Anopheles gambiae)
0 (Immunoglobulin G)
0 (Insect Proteins)
0 (Salivary Proteins and Peptides)
تواريخ الأحداث: Date Created: 20240621 Date Completed: 20240621 Latest Revision: 20240719
رمز التحديث: 20240719
مُعرف محوري في PubMed: PMC11192751
DOI: 10.1038/s41598-024-58337-8
PMID: 38906949
قاعدة البيانات: MEDLINE
الوصف
تدمد:2045-2322
DOI:10.1038/s41598-024-58337-8