دورية أكاديمية
Diagnosis of membranous nephropathy with Anti-GBM glomerulonephritis: a case series report.
| العنوان: | Diagnosis of membranous nephropathy with Anti-GBM glomerulonephritis: a case series report. |
|---|---|
| المؤلفون: | Liu G; Department of Nephrology, The Second Hospital, Dalian Medical University, 467 Zhongshan RoadLiao Ning, Dalian, 116000, China., Feng X; Department of Nephrology, The Second Hospital, Dalian Medical University, 467 Zhongshan RoadLiao Ning, Dalian, 116000, China., Yu S; Department of Nephrology, The Second Hospital, Dalian Medical University, 467 Zhongshan RoadLiao Ning, Dalian, 116000, China., Sheng J; Department of Nephrology, The Second Hospital, Dalian Medical University, 467 Zhongshan RoadLiao Ning, Dalian, 116000, China., Liu C; Department of Nephrology, The Second Hospital, Dalian Medical University, 467 Zhongshan RoadLiao Ning, Dalian, 116000, China., Wang L; Department of Nephrology, The Second Hospital, Dalian Medical University, 467 Zhongshan RoadLiao Ning, Dalian, 116000, China. isabella-lihuawang@163.com. |
| المصدر: | BMC nephrology [BMC Nephrol] 2024 Jun 21; Vol. 25 (1), pp. 204. Date of Electronic Publication: 2024 Jun 21. |
| نوع المنشور: | Journal Article; Case Reports |
| اللغة: | English |
| بيانات الدورية: | Publisher: BioMed Central Country of Publication: England NLM ID: 100967793 Publication Model: Electronic Cited Medium: Internet ISSN: 1471-2369 (Electronic) Linking ISSN: 14712369 NLM ISO Abbreviation: BMC Nephrol Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: London : BioMed Central, [2000- |
| مواضيع طبية MeSH: | Glomerulonephritis, Membranous*/diagnosis , Glomerulonephritis, Membranous*/complications , Glomerulonephritis, Membranous*/pathology , Glomerulonephritis, Membranous*/immunology , Anti-Glomerular Basement Membrane Disease*/diagnosis , Anti-Glomerular Basement Membrane Disease*/complications , Anti-Glomerular Basement Membrane Disease*/therapy , Receptors, Phospholipase A2*/immunology, Humans ; Male ; Female ; Middle Aged ; Adult ; Autoantibodies/blood ; Biopsy ; Glomerulonephritis/diagnosis ; Glomerulonephritis/complications |
| مستخلص: | Background: The concomitant occurrence of membranous nephropathy and anti-glomerular basement (anti-GBM) disease has been previously described but is extremely rare. However, delayed recognition or misdiagnosis leads to delayed treatment, resulting in worse renal and patient outcomes. Case Presentation: We present 3 patients with rapidly progressive glomerulonephritis (RPGN), anti-GBM and serum-positive M-type phospholipase A2 receptor (anti-PLA2R) antibody. Renal biopsies revealed PLA2R-associated membranous nephropathy with anti-GBM glomerulonephritis. We analyzed the clinical and pathological characteristics and discussed that the correct diagnosis of membranous nephropathy with anti-GBM should rely on a combination of renal biopsy findings and serological testing. Despite aggressive treatment, one patient received maintenance hemodialysis, one patient progressed to CKD 3 stage, and the other patient died of cerebral infarction. Conclusion: The simultaneous occurrence of membranous nephropathy and anti-GBM disease is extremely rare. The correct diagnosis of membranous nephropathy with anti-GBM relies on a combination of renal biopsy findings and serological testing. Early diagnosis is needed to improve the renal dysfunction. (© 2024. The Author(s).) |
| References: | Hum Pathol. 1981 Jul;12(7):597-604. (PMID: 7024099) Clin J Am Soc Nephrol. 2009 Feb;4(2):299-308. (PMID: 19158367) Clin Nephrol. 1976 Jul;6(1):319-25. (PMID: 782751) Pathology. 1995 Jul;27(3):233-6. (PMID: 8532389) Kidney Int. 2006 Mar;69(5):894-9. (PMID: 16518348) Am J Med. 1976 Sep;61(3):407-13. (PMID: 961704) Clin Immunol Immunopathol. 1981 Mar;18(3):402-14. (PMID: 7249415) Kidney Int. 2021 Oct;100(4S):S1-S276. (PMID: 34556256) Nephrol Dial Transplant. 2001 Oct;16(10):2082-5. (PMID: 11572902) Nephron. 1984;38(2):134-7. (PMID: 6236378) Am J Clin Pathol. 1982 Sep;78(3):381-6. (PMID: 6180630) N Engl J Med. 1974 Jun 13;290(24):1340-4. (PMID: 4275110) Kidney Int. 2020 Sep;98(3):780-781. (PMID: 32599088) Clin Nephrol. 2006 Aug;66(2):120-7. (PMID: 16939068) Clin Nephrol. 1978 Feb;9(2):77-85. (PMID: 147761) Int J Artif Organs. 1995 Dec;18(12):763-5. (PMID: 8964642) Am J Kidney Dis. 1989 Aug;14(2):145-53. (PMID: 2757019) Nat Rev Immunol. 2023 Nov;23(11):763-778. (PMID: 37095254) Kidney Int. 2014 Apr;85(4):945-52. (PMID: 24048374) Am J Kidney Dis. 2014 Jul;64(1):66-73. (PMID: 24709471) |
| فهرسة مساهمة: | Keywords: Anti-glomerular basement membrane disease; Membranous nephropathy; Rapidly progressive glomerulonephritis |
| المشرفين على المادة: | 0 (Receptors, Phospholipase A2) 0 (Autoantibodies) 0 (PLA2R1 protein, human) 0 (antiglomerular basement membrane antibody) |
| تواريخ الأحداث: | Date Created: 20240621 Date Completed: 20240621 Latest Revision: 20240624 |
| رمز التحديث: | 20240624 |
| مُعرف محوري في PubMed: | PMC11193197 |
| DOI: | 10.1186/s12882-024-03637-4 |
| PMID: | 38907217 |
| قاعدة البيانات: | MEDLINE |
Find this article in full text from Springer Verlag. 
Full Text Finder | تدمد: | 1471-2369 |
|---|---|
| DOI: | 10.1186/s12882-024-03637-4 |