دورية أكاديمية
أعرض في EDS

Amplifications of EVX2 and HOXD9-HOXD13 on 2q31 in mature cystic teratomas of the ovary identified by array comparative genomic hybridization may explain teratoma characteristics in chondrogenesis and osteogenesis.

التفاصيل البيبلوغرافية
العنوان: Amplifications of EVX2 and HOXD9-HOXD13 on 2q31 in mature cystic teratomas of the ovary identified by array comparative genomic hybridization may explain teratoma characteristics in chondrogenesis and osteogenesis.
المؤلفون: Wang WC; Department of Obstetrics and Gynecology, Jen-Ai Hospital, Taichung, Taiwan., Hou TC; Department of Pathology, Jen-Ai Hospital, Taichung, Taiwan., Kuo CY; Department of Pathology, Jen-Ai Hospital, Taichung, Taiwan., Lai YC; Department of Medical Laboratory and Biotechnology, Chung Shan Medical University, No.110, Sec. 1, Chien Kuo N. Road, Taichung, 402, Taiwan, R.O.C.. yenchein@csmu.edu.tw.; Clinical Laboratory, Chung Shan Medical University Hospital, Taichung, Taiwan. yenchein@csmu.edu.tw.
المصدر: Journal of ovarian research [J Ovarian Res] 2024 Jun 21; Vol. 17 (1), pp. 129. Date of Electronic Publication: 2024 Jun 21.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: BioMed Central Country of Publication: England NLM ID: 101474849 Publication Model: Electronic Cited Medium: Internet ISSN: 1757-2215 (Electronic) Linking ISSN: 17572215 NLM ISO Abbreviation: J Ovarian Res Subsets: MEDLINE
أسماء مطبوعة: Original Publication: [London] : BioMed Central, c2008-
مواضيع طبية MeSH: Chondrogenesis*/genetics , Comparative Genomic Hybridization* , Homeodomain Proteins*/genetics , Osteogenesis*/genetics , Ovarian Neoplasms*/genetics , Ovarian Neoplasms*/pathology , Teratoma*/genetics , Teratoma*/pathology , Transcription Factors*/genetics , Transcription Factors*/metabolism, Adult ; Female ; Humans ; Middle Aged ; Neoplasm Proteins
مستخلص: Background: Teratomas are a common type of germ cell tumor. However, only a few reports on their genomic constitution have been published. The study of teratomas may provide a better understanding of their stepwise differentiation processes and molecular bases, which could prove useful for the development of tissue-engineering technologies.
Methods: In the present study, we analyzed the copy number aberrations of nine ovarian mature cystic teratomas using array comparative genomic hybridization in an attempt to reveal their genomic aberrations.
Results: The many chromosomal aberrations observed on array comparative genomic hybridization analysis reveal the complex genetics of this tumor. Amplifications and deletions of large DNA fragments were observed in some samples, while amplifications of EVX2 and HOXD9-HOXD13 on 2q31.1, NDUFV1 on 11q13.2, and RPL10, SNORA70, DNASE1L1, TAZ, ATP6AP1, and GDI1 on Xq28 were found in all nine mature cystic teratomas.
Conclusions: Our results indicated that amplifications of these genes may play an important etiological role in teratoma formation. Moreover, amplifications of EVX2 and HOXD9-HOXD13 on 2q31.1, found on array comparative genomic hybridization, may help to explain the characteristics of teratomas in chondrogenesis and osteogenesis.
(© 2024. The Author(s).)
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فهرسة مساهمة: Keywords: Array comparative genomic hybridization; Chondrogenesis; Mature cystic teratoma of the ovary; Osteogenesis
المشرفين على المادة: 0 (Homeodomain Proteins)
0 (HOXD13 protein, human)
0 (HOXD9 protein, human)
0 (Neoplasm Proteins)
0 (Transcription Factors)
0 (EVX2 protein, human)
SCR Disease Name: Teratoma, Ovarian
تواريخ الأحداث: Date Created: 20240621 Date Completed: 20240621 Latest Revision: 20240719
رمز التحديث: 20240719
مُعرف محوري في PubMed: PMC11193297
DOI: 10.1186/s13048-024-01458-5
PMID: 38907278
قاعدة البيانات: MEDLINE
الوصف
تدمد:1757-2215
DOI:10.1186/s13048-024-01458-5