دورية أكاديمية
PIRCHE-II Risk and Acceptable Mismatch Profile Analysis in Solid Organ Transplantation.
| العنوان: | PIRCHE-II Risk and Acceptable Mismatch Profile Analysis in Solid Organ Transplantation. |
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| المؤلفون: | Niemann M; PIRCHE AG, Berlin, Germany. matthias.niemann@pirche.com., Matern BM; PIRCHE AG, Berlin, Germany.; Center for Translational Immunology, University Medical Center, Utrecht, Netherlands., Spierings E; Center for Translational Immunology, University Medical Center, Utrecht, Netherlands.; Central Diagnostic Laboratory, University Medical Center, Utrecht, Netherlands. |
| المصدر: | Methods in molecular biology (Clifton, N.J.) [Methods Mol Biol] 2024; Vol. 2809, pp. 171-192. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Humana Press Country of Publication: United States NLM ID: 9214969 Publication Model: Print Cited Medium: Internet ISSN: 1940-6029 (Electronic) Linking ISSN: 10643745 NLM ISO Abbreviation: Methods Mol Biol Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Totowa, NJ : Humana Press Original Publication: Clifton, N.J. : Humana Press, |
| مواضيع طبية MeSH: | Organ Transplantation*/adverse effects , Histocompatibility Testing*/methods , HLA Antigens*/genetics , HLA Antigens*/immunology , Algorithms* , Epitopes, T-Lymphocyte*/immunology , Epitopes, T-Lymphocyte*/genetics, Humans ; Graft Rejection/immunology ; Graft Rejection/genetics ; Alleles ; Tissue Donors |
| مستخلص: | To optimize outcomes in solid organ transplantation, the HLA genes are regularly compared and matched between the donor and recipient. However, in many cases a transplant cannot be fully matched, due to widespread variation across populations and the hyperpolymorphism of HLA alleles. Mismatches of the HLA molecules in transplanted tissue can be recognized by immune cells of the recipient, leading to immune response and possibly organ rejection. These adverse outcomes are reduced by analysis using epitope-focused models that consider the immune relevance of the mismatched HLA.PIRCHE, an acronym for Predicted Indirectly ReCognizable HLA Epitopes, aims to categorize and quantify HLA mismatches in a patient-donor pair by predicting HLA-derived T cell epitopes. Specifically, the algorithm predicts and counts the HLA-derived peptides that can be presented by the host HLA, known as indirectly-presented T cell epitopes. Looking at the immune-relevant epitopes within HLA allows a more biologically relevant understanding of immune response, and provides an expanded donor pool for a more refined matching strategy compared with allele-level matching. This PIRCHE algorithm is available for analysis of single transplantations, as well as bulk analysis for population studies and statistical analysis for comparison of probability of organ availability and risk profiles. (© 2024. The Author(s), under exclusive license to Springer Science+Business Media, LLC, part of Springer Nature.) |
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| فهرسة مساهمة: | Keywords: Compatibility; Epitope; HLA; Matching algorithm; Molecular mismatch; Solid organ transplantation |
| المشرفين على المادة: | 0 (HLA Antigens) 0 (Epitopes, T-Lymphocyte) |
| تواريخ الأحداث: | Date Created: 20240622 Date Completed: 20240622 Latest Revision: 20240622 |
| رمز التحديث: | 20240623 |
| DOI: | 10.1007/978-1-0716-3874-3_12 |
| PMID: | 38907898 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1940-6029 |
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| DOI: | 10.1007/978-1-0716-3874-3_12 |