دورية أكاديمية
أعرض في EDS

Uncertainty of treatment efficacy moderates placebo effects on reinforcement learning.

التفاصيل البيبلوغرافية
العنوان: Uncertainty of treatment efficacy moderates placebo effects on reinforcement learning.
المؤلفون: Augustat N; Department of Psychology, University of Marburg, Marburg, Germany. nick.augustat@staff.uni-marburg.de., Endres D; Department of Psychology, University of Marburg, Marburg, Germany., Mueller EM; Department of Psychology, University of Marburg, Marburg, Germany.
المصدر: Scientific reports [Sci Rep] 2024 Jun 22; Vol. 14 (1), pp. 14421. Date of Electronic Publication: 2024 Jun 22.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE
أسماء مطبوعة: Original Publication: London : Nature Publishing Group, copyright 2011-
مواضيع طبية MeSH: Placebo Effect* , Reinforcement, Psychology* , Reward*, Humans ; Male ; Uncertainty ; Female ; Adult ; Young Adult ; Learning ; Treatment Outcome ; Dopamine/metabolism ; Adolescent
مستخلص: The placebo-reward hypothesis postulates that positive effects of treatment expectations on health (i.e., placebo effects) and reward processing share common neural underpinnings. Moreover, experiments in humans and animals indicate that reward uncertainty increases striatal dopamine, which is presumably involved in placebo responses and reward learning. Therefore, treatment uncertainty analogously to reward uncertainty may affect updating from rewards after placebo treatment. Here, we address whether different degrees of uncertainty regarding the efficacy of a sham treatment affect reward sensitivity. In an online between-subjects experiment with N = 141 participants, we systematically varied the provided efficacy instructions before participants first received a sham treatment that consisted of listening to binaural beats and then performed a probabilistic reinforcement learning task. We fitted a Q-learning model including two different learning rates for positive (gain) and negative (loss) reward prediction errors and an inverse gain parameter to behavioral decision data in the reinforcement learning task. Our results yielded an inverted-U-relationship between provided treatment efficacy probability and learning rates for gain, such that higher levels of treatment uncertainty, rather than of expected net efficacy, affect presumably dopamine-related reward learning. These findings support the placebo-reward hypothesis and suggest harnessing uncertainty in placebo treatment for recovering reward learning capabilities.
(© 2024. The Author(s).)
References: Eval Health Prof. 2002 Dec;25(4):410-20. (PMID: 12449084)
Curr Biol. 2022 Mar 14;32(5):1077-1087.e9. (PMID: 35114098)
Trends Neurosci. 2020 Oct;43(10):795-809. (PMID: 32736849)
Dev Cogn Neurosci. 2020 Feb;41:100732. (PMID: 31826837)
Behav Res Methods. 2015 Mar;47(1):1-12. (PMID: 24683129)
J Clin Psychiatry. 2010 Mar;71(3):270-9. (PMID: 20122371)
Nat Neurosci. 2007 Sep;10(9):1214-21. (PMID: 17676057)
Elife. 2019 Nov 26;8:. (PMID: 31769410)
Curr Opin Psychol. 2015 Aug 1;4:114-118. (PMID: 26258159)
Neuroimage. 2019 Feb 1;186:113-125. (PMID: 30381245)
Biol Psychiatry. 2021 Jan 15;89(2):134-143. (PMID: 32797941)
Comput Psychiatr. 2017;1(1):208-233. (PMID: 29400358)
Prog Neuropsychopharmacol Biol Psychiatry. 2018 Dec 20;87(Pt B):183-192. (PMID: 28797640)
Neuroimage. 2012 Aug 1;62(1):154-66. (PMID: 22548809)
Proc Natl Acad Sci U S A. 2011 Dec 6;108(49):19767-71. (PMID: 22106310)
Int J Psychophysiol. 2014 Dec;94(3):399-406. (PMID: 25448376)
Annu Rev Neurosci. 2015 Jul 8;38:1-23. (PMID: 25705929)
Trends Neurosci. 2007 May;30(5):203-10. (PMID: 17400301)
eNeuro. 2020 Mar 19;7(2):. (PMID: 32066611)
Psychiatry Res. 2012 Oct 30;204(1):55-60. (PMID: 22889563)
Int J Epidemiol. 2018 Oct 1;47(5):1454-1464. (PMID: 29878123)
Nature. 2006 Aug 31;442(7106):1042-5. (PMID: 16929307)
Clin Psychol Rev. 2019 Apr;69:51-66. (PMID: 29961601)
Psychother Psychosom. 2020;89(6):371-378. (PMID: 32492688)
Comput Psychiatr. 2017 Oct 01;1:24-57. (PMID: 29601060)
Proc Natl Acad Sci U S A. 2007 Oct 9;104(41):16311-6. (PMID: 17913879)
Biol Psychiatry Cogn Neurosci Neuroimaging. 2020 Feb;5(2):163-172. (PMID: 31784354)
Psychopharmacology (Berl). 2019 Aug;236(8):2425-2435. (PMID: 31346654)
Sci Rep. 2018 Nov 28;8(1):17443. (PMID: 30487547)
Curr Opin Behav Sci. 2018 Aug;22:128-135. (PMID: 29503842)
Nat Rev Neurosci. 2019 Oct;20(10):635-644. (PMID: 31147631)
Parkinsonism Relat Disord. 2009 Dec;15 Suppl 3:S72-4. (PMID: 20083013)
J Neurosci. 2017 Oct 4;37(40):9715-9723. (PMID: 28883019)
Nat Neurosci. 2011 Oct 09;14(11):1475-9. (PMID: 21983684)
Science. 2005 Mar 11;307(5715):1642-5. (PMID: 15761155)
Eur Neuropsychopharmacol. 2009 Jan;19(1):34-40. (PMID: 18823760)
Mol Psychiatry. 2015 Apr;20(4):416-23. (PMID: 25510510)
Front Hum Neurosci. 2010 Dec 02;4:215. (PMID: 21160551)
Sci Rep. 2021 Feb 16;11(1):3855. (PMID: 33594150)
Sci Rep. 2017 Jan 23;7:41028. (PMID: 28112207)
Health Psychol Rev. 2018 Dec;12(4):419-436. (PMID: 30205757)
Neuropsychopharmacology. 2014 Sep;39(10):2366-75. (PMID: 24713613)
Neuron. 2005 May 19;46(4):681-92. (PMID: 15944135)
Nat Neurosci. 2014 Dec;17(12):1793-7. (PMID: 25326691)
Neuron. 2006 Aug 3;51(3):381-90. (PMID: 16880132)
PLoS Comput Biol. 2016 Sep 02;12(9):e1005062. (PMID: 27589489)
Nature. 2020 Jan;577(7792):671-675. (PMID: 31942076)
PLoS One. 2018 Sep 7;13(9):e0203574. (PMID: 30192853)
Science. 2003 Mar 21;299(5614):1898-902. (PMID: 12649484)
Arch Gen Psychiatry. 2010 Aug;67(8):857-65. (PMID: 20679593)
Curr Opin Behav Sci. 2021 Oct;41:128-137. (PMID: 34984213)
Nature. 2019 Jun;570(7759):65-70. (PMID: 31118513)
Science. 2004 Dec 10;306(5703):1940-3. (PMID: 15528409)
Nat Hum Behav. 2019 Oct;3(10):1116-1123. (PMID: 31209369)
Psychiatry Res. 2018 Feb;260:138-143. (PMID: 29195165)
Neuron. 2017 Jan 18;93(2):451-463. (PMID: 28103483)
Open Mind (Camb). 2022 Nov 30;6:250-263. (PMID: 36891036)
PLoS Comput Biol. 2017 Aug 11;13(8):e1005684. (PMID: 28800597)
Int J Psychophysiol. 2014 Jul;93(1):134-9. (PMID: 23085086)
Behav Neurosci. 2023 Feb;137(1):78-88. (PMID: 36395020)
Science. 1997 Mar 14;275(5306):1593-9. (PMID: 9054347)
Brain Res. 2010 Nov 4;1359:137-41. (PMID: 20735999)
Front Psychol. 2021 Nov 11;12:726432. (PMID: 34858264)
PLoS Comput Biol. 2020 Sep 30;16(9):e1008276. (PMID: 32997659)
JAMA Psychiatry. 2022 Apr 01;79(4):313-322. (PMID: 35234834)
Annu Rev Psychol. 2019 Jan 4;70:599-625. (PMID: 30110575)
Nat Rev Neurosci. 2015 Jul;16(7):403-18. (PMID: 26087681)
Am J Psychiatry. 2017 Apr 1;174(4):378-386. (PMID: 27771973)
Psychon Bull Rev. 2007 Oct;14(5):779-804. (PMID: 18087943)
Trends Cogn Sci. 2019 Oct;23(10):865-875. (PMID: 31431340)
معلومات مُعتمدة: 422744262 Deutsche Forschungsgemeinschaft (DFG, German Research Foundation; project "TRR289 - Treatment Expectation"); 422744262 Deutsche Forschungsgemeinschaft (DFG, German Research Foundation; project "TRR289 - Treatment Expectation"); 422744262 Deutsche Forschungsgemeinschaft (DFG, German Research Foundation; project "TRR289 - Treatment Expectation"); 290878970-GRK 2271 Deutsche Forschungsgemeinschaft (DFG, German Research Foundation; project "GRK2271 - Breaking Expectations"); 290878970-GRK 2271 Deutsche Forschungsgemeinschaft (DFG, German Research Foundation; project "GRK2271 - Breaking Expectations"); 290878970-GRK 2271 Deutsche Forschungsgemeinschaft (DFG, German Research Foundation; project "GRK2271 - Breaking Expectations")
المشرفين على المادة: VTD58H1Z2X (Dopamine)
تواريخ الأحداث: Date Created: 20240622 Date Completed: 20240622 Latest Revision: 20240625
رمز التحديث: 20240625
مُعرف محوري في PubMed: PMC11193823
DOI: 10.1038/s41598-024-64240-z
PMID: 38909105
قاعدة البيانات: MEDLINE
الوصف
تدمد:2045-2322
DOI:10.1038/s41598-024-64240-z