دورية أكاديمية
Glycooligomer-Functionalized Catalytic Nanocompartments Co-Loaded with Enzymes Support Parallel Reactions and Promote Cell Internalization.
العنوان: | Glycooligomer-Functionalized Catalytic Nanocompartments Co-Loaded with Enzymes Support Parallel Reactions and Promote Cell Internalization. |
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المؤلفون: | Korpidou M; Department of Chemistry, University of Basel, Mattenstrasse 22, Basel 4002, Switzerland., Becker J; Department of Chemistry, University of Warwick, Coventry CV4 7AL, United Kingdom., Tarvirdipour S; Department of Chemistry, University of Basel, Mattenstrasse 22, Basel 4002, Switzerland., Dinu IA; Department of Chemistry, University of Basel, Mattenstrasse 22, Basel 4002, Switzerland., Becer CR; Department of Chemistry, University of Warwick, Coventry CV4 7AL, United Kingdom., Palivan CG; Department of Chemistry, University of Basel, Mattenstrasse 22, Basel 4002, Switzerland.; NCCR Molecular Systems Engineering, Mattenstrasse 22, Basel 4002, Switzerland. |
المصدر: | Biomacromolecules [Biomacromolecules] 2024 Jul 08; Vol. 25 (7), pp. 4492-4509. Date of Electronic Publication: 2024 Jun 23. |
نوع المنشور: | Journal Article |
اللغة: | English |
بيانات الدورية: | Publisher: American Chemical Society Country of Publication: United States NLM ID: 100892849 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1526-4602 (Electronic) Linking ISSN: 15257797 NLM ISO Abbreviation: Biomacromolecules Subsets: MEDLINE |
أسماء مطبوعة: | Original Publication: Washington, DC : American Chemical Society, c2000- |
مواضيع طبية MeSH: | Glucose Oxidase*/chemistry , Glucose Oxidase*/metabolism , Hydrogen Peroxide*/chemistry , Hydrogen Peroxide*/metabolism, Humans ; Hep G2 Cells ; Glucuronidase/metabolism ; Cell Survival/drug effects ; Catalysis ; Reactive Oxygen Species/metabolism ; Oligosaccharides/chemistry ; Oligosaccharides/metabolism |
مستخلص: | A major shortcoming associated with the application of enzymes in drug synergism originates from the lack of site-specific, multifunctional nanomedicine. This study introduces catalytic nanocompartments (CNCs) made of a mixture of PDMS- b -PMOXA diblock copolymers, decorated with glycooligomer tethers comprising eight mannose-containing repeating units and coencapsulating two enzymes, providing multifunctionality by their in situ parallel reactions. Beta-glucuronidase (GUS) serves for local reactivation of the drug hymecromone, while glucose oxidase (GOx) induces cell starvation through glucose depletion and generation of the cytotoxic H |
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المشرفين على المادة: | EC 1.1.3.4 (Glucose Oxidase) BBX060AN9V (Hydrogen Peroxide) EC 3.2.1.31 (Glucuronidase) 0 (Reactive Oxygen Species) 0 (Oligosaccharides) |
تواريخ الأحداث: | Date Created: 20240624 Date Completed: 20240708 Latest Revision: 20240714 |
رمز التحديث: | 20240714 |
مُعرف محوري في PubMed: | PMC11238334 |
DOI: | 10.1021/acs.biomac.4c00526 |
PMID: | 38910355 |
قاعدة البيانات: | MEDLINE |
تدمد: | 1526-4602 |
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DOI: | 10.1021/acs.biomac.4c00526 |