دورية أكاديمية
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Glycooligomer-Functionalized Catalytic Nanocompartments Co-Loaded with Enzymes Support Parallel Reactions and Promote Cell Internalization.

التفاصيل البيبلوغرافية
العنوان: Glycooligomer-Functionalized Catalytic Nanocompartments Co-Loaded with Enzymes Support Parallel Reactions and Promote Cell Internalization.
المؤلفون: Korpidou M; Department of Chemistry, University of Basel, Mattenstrasse 22, Basel 4002, Switzerland., Becker J; Department of Chemistry, University of Warwick, Coventry CV4 7AL, United Kingdom., Tarvirdipour S; Department of Chemistry, University of Basel, Mattenstrasse 22, Basel 4002, Switzerland., Dinu IA; Department of Chemistry, University of Basel, Mattenstrasse 22, Basel 4002, Switzerland., Becer CR; Department of Chemistry, University of Warwick, Coventry CV4 7AL, United Kingdom., Palivan CG; Department of Chemistry, University of Basel, Mattenstrasse 22, Basel 4002, Switzerland.; NCCR Molecular Systems Engineering, Mattenstrasse 22, Basel 4002, Switzerland.
المصدر: Biomacromolecules [Biomacromolecules] 2024 Jul 08; Vol. 25 (7), pp. 4492-4509. Date of Electronic Publication: 2024 Jun 23.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: American Chemical Society Country of Publication: United States NLM ID: 100892849 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1526-4602 (Electronic) Linking ISSN: 15257797 NLM ISO Abbreviation: Biomacromolecules Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Washington, DC : American Chemical Society, c2000-
مواضيع طبية MeSH: Glucose Oxidase*/chemistry , Glucose Oxidase*/metabolism , Hydrogen Peroxide*/chemistry , Hydrogen Peroxide*/metabolism, Humans ; Hep G2 Cells ; Glucuronidase/metabolism ; Cell Survival/drug effects ; Catalysis ; Reactive Oxygen Species/metabolism ; Oligosaccharides/chemistry ; Oligosaccharides/metabolism
مستخلص: A major shortcoming associated with the application of enzymes in drug synergism originates from the lack of site-specific, multifunctional nanomedicine. This study introduces catalytic nanocompartments (CNCs) made of a mixture of PDMS- b -PMOXA diblock copolymers, decorated with glycooligomer tethers comprising eight mannose-containing repeating units and coencapsulating two enzymes, providing multifunctionality by their in situ parallel reactions. Beta-glucuronidase (GUS) serves for local reactivation of the drug hymecromone, while glucose oxidase (GOx) induces cell starvation through glucose depletion and generation of the cytotoxic H 2 O 2 . The insertion of the pore-forming peptide, melittin, facilitates diffusion of substrates and products through the membranes. Increased cell-specific internalization of the CNCs results in a substantial decrease in HepG2 cell viability after 24 h, attributed to simultaneous production of hymecromone and H 2 O 2 . Such parallel enzymatic reactions taking place in nanocompartments pave the way to achieve efficient combinatorial cancer therapy by enabling localized drug production along with reactive oxygen species (ROS) elevation.
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المشرفين على المادة: EC 1.1.3.4 (Glucose Oxidase)
BBX060AN9V (Hydrogen Peroxide)
EC 3.2.1.31 (Glucuronidase)
0 (Reactive Oxygen Species)
0 (Oligosaccharides)
تواريخ الأحداث: Date Created: 20240624 Date Completed: 20240708 Latest Revision: 20240714
رمز التحديث: 20240714
مُعرف محوري في PubMed: PMC11238334
DOI: 10.1021/acs.biomac.4c00526
PMID: 38910355
قاعدة البيانات: MEDLINE
الوصف
تدمد:1526-4602
DOI:10.1021/acs.biomac.4c00526