دورية أكاديمية
Pathogenic roles of follicular helper T cells in IgG4-related disease and implications for potential therapy.
| العنوان: | Pathogenic roles of follicular helper T cells in IgG4-related disease and implications for potential therapy. |
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| المؤلفون: | Xu J; Department of Rheumatology and Immunology, Peking University Third Hospital, Beijing, China., Zhai J; Department of Rheumatology and Immunology, Peking University Third Hospital, Beijing, China.; Center for Rare Disease, Peking University Third Hospital, Beijing, China., Zhao J; Department of Rheumatology and Immunology, Peking University Third Hospital, Beijing, China.; Center for Rare Disease, Peking University Third Hospital, Beijing, China. |
| المصدر: | Frontiers in immunology [Front Immunol] 2024 Jun 07; Vol. 15, pp. 1413860. Date of Electronic Publication: 2024 Jun 07 (Print Publication: 2024). |
| نوع المنشور: | Journal Article; Review |
| اللغة: | English |
| بيانات الدورية: | Publisher: Frontiers Research Foundation] Country of Publication: Switzerland NLM ID: 101560960 Publication Model: eCollection Cited Medium: Internet ISSN: 1664-3224 (Electronic) Linking ISSN: 16643224 NLM ISO Abbreviation: Front Immunol Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: [Lausanne : Frontiers Research Foundation] |
| مواضيع طبية MeSH: | Immunoglobulin G4-Related Disease*/immunology , Immunoglobulin G4-Related Disease*/diagnosis , Immunoglobulin G4-Related Disease*/therapy , T Follicular Helper Cells*/immunology , Immunoglobulin G*/immunology , Germinal Center*/immunology, Humans ; Animals ; Plasma Cells/immunology ; T-Lymphocytes, Helper-Inducer/immunology ; Biomarkers |
| مستخلص: | IgG4-related disease (IgG4-RD) is a recently described autoimmune disorder characterized by elevated serum IgG4 levels and tissue infiltration of IgG4 + plasma cells in multiple organ systems. Recent advancements have significantly enhanced our understanding of the pathological mechanism underlying this immune-mediated disease. T cell immunity plays a crucial role in the pathogenesis of IgG4-RD, and follicular helper T cells (Tfh) are particularly important in germinal center (GC) formation, plasmablast differentiation, and IgG4 class-switching. Apart from serum IgG4 concentrations, the expansion of circulating Tfh2 cells and plasmablasts may also serve as novel biomarkers for disease diagnosis and activity monitoring in IgG4-RD. Further exploration into the pathogenic roles of Tfh in IgG4-RD could potentially lead to identifying new therapeutic targets that offer more effective alternatives for treating this condition. In this review, we will focus on the current knowledge regarding the pathogenic roles Tfh cells play in IgG4-RD and outline potential therapeutic targets for future clinical intervention. Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. (Copyright © 2024 Xu, Zhai and Zhao.) |
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| فهرسة مساهمة: | Keywords: IgG4-related disease; T lymphocyte; follicular helper T cells; pathogenesis; therapeutic targets |
| المشرفين على المادة: | 0 (Immunoglobulin G) 0 (Biomarkers) |
| تواريخ الأحداث: | Date Created: 20240624 Date Completed: 20240624 Latest Revision: 20240625 |
| رمز التحديث: | 20240625 |
| مُعرف محوري في PubMed: | PMC11190345 |
| DOI: | 10.3389/fimmu.2024.1413860 |
| PMID: | 38911857 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1664-3224 |
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| DOI: | 10.3389/fimmu.2024.1413860 |