دورية أكاديمية
أعرض في EDS

Determinants of neonatal seizure among neonates admitted to neonatal intensive care units in the Awi Zone hospitals, 2023: A multi-center unmatched case control study.

التفاصيل البيبلوغرافية
العنوان: Determinants of neonatal seizure among neonates admitted to neonatal intensive care units in the Awi Zone hospitals, 2023: A multi-center unmatched case control study.
المؤلفون: Alene T; Department of Pediatrics and Child Health Nursing, College of Medicine and Health Sciences, Injibara University, Injibara, Amhara, Ethiopia., Tsega TD; Departmrnt of Public Health, College of Medicine and Health Sciences, Injibara University, Injibara, Amhara, Ethiopia., Terefe TF; Department of Pediatrics and Child Health Nursing, College of Medicine and Health Sciences, Injibara University, Injibara, Amhara, Ethiopia., Dessalegn N; Department of Pediatrics and Child Health Nursing, College of Medicine and Health Sciences, Injibara University, Injibara, Amhara, Ethiopia., Alem ZA; Department of Clinical Nursing, Hossana Health Sciences College, southern Nation nationalities and people of Ethiopia, Ethiopia., Tamir W; Department of Medical Laboratory Science, College of Medicine and Health Sciences, Injibara University, Injibara, Amhara, Ethiopia., Tesfa AA; Department of Orthopedic Surgery, College of Medicine and Health Sciences, Injibara University, Injibara, Amhara, Ethiopia., Mitiku YA; Department of Internal Medicine, Injibara General Hospital, Injibara, Amhara, Ethiopia., Aynalem ZB; Department of Nursing, College of Medicine and Health Sciences, Injibara University, Injibara, Amhara, Ethiopia., Melaku WN; Department of Medicine, MSF Holland, Abdurafi Project, Ethiopia., Amare G; Deparment of Midwifery College of Medicine and Health Sciences, Injibara University, Injibara, Amhara, Ethiopia., Alemu BW; Department of Midwifery College of Medicine and Health Sciences, Injibara University, Injibara, Amhara, Ethiopia.
المصدر: Heliyon [Heliyon] 2024 Jun 07; Vol. 10 (11), pp. e32537. Date of Electronic Publication: 2024 Jun 07 (Print Publication: 2024).
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Elsevier Ltd Country of Publication: England NLM ID: 101672560 Publication Model: eCollection Cited Medium: Print ISSN: 2405-8440 (Print) Linking ISSN: 24058440 NLM ISO Abbreviation: Heliyon Subsets: PubMed not MEDLINE
أسماء مطبوعة: Original Publication: London : Elsevier Ltd, [2015]-
مستخلص: Background: Neonatal seizure is a common medical emergency that signals severe insult to the neonatal brain. It is a major risk factor for neonatal morbidity and mortality. It has a wide worldwide variation, ranging from 5 per 1000 live births in the United States of America to 39.5 per 1000 live births in Kenya. To decrease this significant figure, it is better to investigate its causes further. Therefore, this study aimed to assess its determinants since there was no prior evidence about it in the context of study area.
Objective: Aim to assess the determinants of neonatal seizures among neonates admitted to neonatal intensive care units in the Awi Zone Hospitals, 2023.
Methods: An institution based unmatched case-control study was conducted on 531 admitted eligible neonates from January 1, 2023, to May 30, 2023. A pretested tool was employed to collect data. The collected data were coded, edited, and entered into Epi-data version 3.1 and then exported to SPSS 26. Chi-square and odds ratios were used to assess the relationship between factors associated with the occurrence of neonatal seizure. Model goodness of fit was tested by Hosmer and Lemeshow. Bivariate and multivariate analysis was declared at P < 0.25 and P < 0.05 respectively to show a significant association with neonatal seizure at a 95 % level of significance.
Results: A total of 506 (130 cases and 376 controls) of admitted neonates were used in the final analysis model. Neonates admitted within 24 h of birth [AOR; 5.98 (95 %, CI: 2.18-16.43)], gestational age <32 weeks [AOR; 2.89 (95 %, CI: 1.29-6.53)], body temperature >37.5 °C [AOR; 4.82 (95 %, CI: 1.82-12.76)], blood glucose level <40 g/dl [AOR; 4.95 (95 %, CI: 2.06,11.88)], neonatal sepsis [AOR; 2.79 (95 %, CI: 1.46-5.35)] and perinatal asphyxia [AOR; 8.25 (95 %, CI: 4.23, 16.12)] were found to be determinants of neonatal seizure.
Conclusion: and recommendations: In this study, neonatal seizure was determined by the factors of neonatal age, gestational age<32 weeks, body temperature >37.5 °C, blood glucose level <40 g/dl, neonatal sepsis, and perinatal asphyxia. Therefore, the presence of such factors requires prompt recognition and treatment.
Competing Interests: The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(© 2024 Published by Elsevier Ltd.)
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فهرسة مساهمة: Keywords: Case control; Determinants; Ethiopia; Neonates; Seizure
تواريخ الأحداث: Date Created: 20240624 Latest Revision: 20240625
رمز التحديث: 20240625
مُعرف محوري في PubMed: PMC11193020
DOI: 10.1016/j.heliyon.2024.e32537
PMID: 38912494
قاعدة البيانات: MEDLINE
الوصف
تدمد:2405-8440
DOI:10.1016/j.heliyon.2024.e32537