دورية أكاديمية
The Effect of Exposure to Neighborhood Violence on Glucocorticoid Receptor Signaling in Lung Tumors.
| العنوان: | The Effect of Exposure to Neighborhood Violence on Glucocorticoid Receptor Signaling in Lung Tumors. |
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| المؤلفون: | Heath H; Department of Food Science and Human Nutrition, University of Illinois Urbana-Champaign, Urbana, Illinois., Yoo JY; Department of Food Science and Human Nutrition, University of Illinois Urbana-Champaign, Urbana, Illinois., Akter S; Department of Food Science and Human Nutrition, University of Illinois Urbana-Champaign, Urbana, Illinois., Jain A; National Center for Supercomputing Applications, University of Illinois Urbana-Champaign, Urbana, Illinois., Sharma V; School of Molecular and Cellular Biology, College of Liberal Arts and Sciences, University of Illinois Urbana-Champaign, Urbana, Illinois., McGee H; School of Molecular and Cellular Biology, College of Liberal Arts and Sciences, University of Illinois Urbana-Champaign, Urbana, Illinois., Soliman A; National Center for Supercomputing Applications, University of Illinois Urbana-Champaign, Urbana, Illinois., Mahmoud AM; Department of Medicine, University of Illinois Chicago, Chicago, Illinois.; Department of Kinesiology and Nutrition, University of Illinois Chicago, Chicago, Illinois., Matthews AK; School of Nursing, Columbia University, New York, New York., Winn RA; Massey Cancer Center, Virginia Commonwealth University, Richmond, Virginia., Madak-Erdogan Z; Department of Food Science and Human Nutrition, University of Illinois Urbana-Champaign, Urbana, Illinois.; National Center for Supercomputing Applications, University of Illinois Urbana-Champaign, Urbana, Illinois.; Cancer Center at Illinois, University of Illinois Urbana-Champaign, Urbana, Illinois.; Institute for Genomic Biology, University of Illinois Urbana-Champaign, Urbana, Illinois., Kim SJ; School of Public Health, University of Illinois Chicago, Chicago, Illinois.; University of Illinois Cancer Center, Chicago, Illinois. |
| المصدر: | Cancer research communications [Cancer Res Commun] 2024 Jul 01; Vol. 4 (7), pp. 1643-1654. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: American Association for Cancer Research Country of Publication: United States NLM ID: 9918281580506676 Publication Model: Print Cited Medium: Internet ISSN: 2767-9764 (Electronic) Linking ISSN: 27679764 NLM ISO Abbreviation: Cancer Res Commun Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: [Philadelphia, Pennsylvania] : American Association for Cancer Research, [2021]- |
| مواضيع طبية MeSH: | Receptors, Glucocorticoid*/genetics , Receptors, Glucocorticoid*/metabolism , Lung Neoplasms*/genetics , Lung Neoplasms*/epidemiology , Lung Neoplasms*/metabolism , Signal Transduction* , Residence Characteristics*/statistics & numerical data , Stress, Psychological*/genetics , Stress, Psychological*/epidemiology , Stress, Psychological*/metabolism , Violence*/statistics & numerical data , Violence*/ethnology, Humans ; Male ; Chicago/epidemiology ; Black or African American/genetics ; Black or African American/statistics & numerical data ; Gene Expression Regulation, Neoplastic ; Middle Aged |
| مستخلص: | Despite lower rates and intensity of smoking, Black men experience a higher incidence of lung cancer compared to white men. The racial disparity in lung cancer is particularly pronounced in Chicago, a highly segregated urban city. Neighborhood conditions, particularly social stress, may play a role in lung tumorigenesis. Preliminary studies indicate that Black men residing in neighborhoods with higher rates of violent crime have significantly higher levels of hair cortisol, an indicator of stress response. To examine the relationship between social stress exposure and gene expression in lung tumors, we investigated glucocorticoid receptor (GR) binding in 15 lung tumor samples in relation to GR target gene expression levels and zip code level residential violent crime rates. Spatial transcriptomics and a version of ChIP sequencing known as CUT&RUN were used. Heatmap of genes, pathway analysis, and motif analysis were conducted at the statistical significance of P < 0.05. GR recruitment to chromatin was correlated with zip code level residential violent crime rate and overall GR binding increased with higher violent crime rates. Our findings suggest that exposure to residential violent crime may influence tumor biology via reprogramming GR recruitment. Prioritizing lung cancer screening in neighborhoods with increased social stress, such as high levels of violent crime, may reduce racial disparities in lung cancer. Significance: Exposure to neighborhood violent crime is correlated with glucocorticoid signaling and lung tumor gene expression changes associated with increased tumor aggressiveness, suggesting social conditions have downstream biophysical consequences that contribute to lung cancer disparities. (©2024 The Authors; Published by the American Association for Cancer Research.) |
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| معلومات مُعتمدة: | R01 MD014839 United States MD NIMHD NIH HHS; T32EB019944 United States EB NIBIB NIH HHS; 5R01MD014839 United States MD NIMHD NIH HHS; Illinois Computes National Center for Supercomputing Applications; Distinguished Merit Fellowship UIUC Graduate College; T32 EB019944 United States EB NIBIB NIH HHS |
| المشرفين على المادة: | 0 (Receptors, Glucocorticoid) |
| تواريخ الأحداث: | Date Created: 20240624 Date Completed: 20240703 Latest Revision: 20240705 |
| رمز التحديث: | 20240705 |
| مُعرف محوري في PubMed: | PMC11221527 |
| DOI: | 10.1158/2767-9764.CRC-24-0032 |
| PMID: | 38912926 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 2767-9764 |
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| DOI: | 10.1158/2767-9764.CRC-24-0032 |