دورية أكاديمية
Tracing the footprints of MPXV in Asia: phylogenetic insights and lineage dynamics.
| العنوان: | Tracing the footprints of MPXV in Asia: phylogenetic insights and lineage dynamics. |
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| المؤلفون: | Chen YC; Division of Infectious Diseases, Taichung Veterans General Hospital, Taichung, Taiwan., Liao YC; Institute of Population Health Sciences, National Health Research Institutes, Miaoli, Taiwan., Mao YC; Division of Clinical Toxicology, Department of Emergency Medicine, Taichung Veterans General Hospital, Taichung, Taiwan.; School of Medicine, National Defense Medical Center, Taichung, Taiwan.; Department of Post-Baccalaureate Medicine, College of Medicine, National Chung Hsing University, Taichung, Taiwan., Yeh TK; Division of Infectious Diseases, Taichung Veterans General Hospital, Taichung, Taiwan., Liu PY; Division of Infectious Diseases, Taichung Veterans General Hospital, Taichung, Taiwan pyliu@vghtc.gov.tw.; Department of Post-Baccalaureate Medicine, College of Medicine, National Chung Hsing University, Taichung, Taiwan.; Ph.D. Program in Translational Medicine, National Chung Hsing University, Taichung, Taiwan.; Rong Hsing Research Center for Translational Medicine, National Chung Hsing University, Taichung, Taiwan. |
| المصدر: | Sexually transmitted infections [Sex Transm Infect] 2024 Aug 19; Vol. 100 (6), pp. 384-387. Date of Electronic Publication: 2024 Aug 19. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: BMJ Pub. Group Country of Publication: England NLM ID: 9805554 Publication Model: Electronic Cited Medium: Internet ISSN: 1472-3263 (Electronic) Linking ISSN: 13684973 NLM ISO Abbreviation: Sex Transm Infect Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: London : BMJ Pub. Group, c1998- |
| مواضيع طبية MeSH: | Phylogeny* , Mutation* , Genome, Viral* , Monkeypox virus*/genetics, Asia/epidemiology ; Humans ; Mpox (monkeypox)/epidemiology ; Mpox (monkeypox)/virology ; Disease Outbreaks ; Evolution, Molecular |
| مستخلص: | Objectives: The 2022 global outbreak of monkeypox virus (MPXV), previously confined to Central and West Africa, necessitates an enhanced understanding of its spread. Comprehensive genomic surveillance to understand the virus's evolution and spread is needed, particularly in Asia. Methods: Genomic data from 169 MPXV genome sequences in Asia were analysed. Through advanced genomic sequencing of clinical samples, we analysed the distribution and mutations of MPXV lineages in Asia. Results: Phylogenetic analysis revealed a distinct clustering of C.1 strains rise in Northeast Asia in 2023, while genomic examination identified specific consensus mutations like R84K, R665C and L16F in C.1 strains. The mutations, coupled with an increased rate of apolipoprotein B mRNA-editing catalytic polypeptide-like 3 motif G-to-A mutations in C.1 (OR 24.87±8.81), indicate a potential adaptation mechanism. Conclusions: Our findings underscore the need for ongoing surveillance and provide vital insights into MPXV's evolving dynamics, aiding in public health strategy formulation against this emerging infectious threat. Competing Interests: Competing interests: None declared. (© Author(s) (or their employer(s)) 2024. No commercial re-use. See rights and permissions. Published by BMJ.) |
| فهرسة مساهمة: | Keywords: Epidemiology; SEXUAL HEALTH; VIROLOGY |
| تواريخ الأحداث: | Date Created: 20240624 Date Completed: 20240819 Latest Revision: 20240819 |
| رمز التحديث: | 20240820 |
| DOI: | 10.1136/sextrans-2024-056119 |
| PMID: | 38914476 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1472-3263 |
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| DOI: | 10.1136/sextrans-2024-056119 |