دورية أكاديمية
Inhibitory Action of 1,3,5-Trihydroxybenzene on UVB-Induced NADPH Oxidase 4 through AMPK and JNK Signaling Pathways.
| العنوان: | Inhibitory Action of 1,3,5-Trihydroxybenzene on UVB-Induced NADPH Oxidase 4 through AMPK and JNK Signaling Pathways. |
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| المؤلفون: | Lim C; Department of Orthopedic Surgery, Jeju National University Hospital, College of Medicine, Jeju National University, Jeju 63241, Republic of Korea., Piao MJ; Department of Biochemistry, College of Medicine, and Jeju Research Center for Natural Medicine, Jeju National University, Jeju 63243, Republic of Korea., Kang KA; Department of Biochemistry, College of Medicine, and Jeju Research Center for Natural Medicine, Jeju National University, Jeju 63243, Republic of Korea., Fernando PDSM; Department of Biochemistry, College of Medicine, and Jeju Research Center for Natural Medicine, Jeju National University, Jeju 63243, Republic of Korea., Herath HMUL; Department of Biochemistry, College of Medicine, and Jeju Research Center for Natural Medicine, Jeju National University, Jeju 63243, Republic of Korea., Kim DW; Department of Orthopedic Surgery, Jeju National University Hospital, College of Medicine, Jeju National University, Jeju 63241, Republic of Korea., Yi JM; Department of Microbiology and Immunology, Inje University College of Medicine, Busan 47392, Republic of Korea., Choi YH; Department of Biochemistry, College of Oriental Medicine, Dongeui University, Busan 47340, Republic of Korea., Hyun JW; Department of Biochemistry, College of Medicine, and Jeju Research Center for Natural Medicine, Jeju National University, Jeju 63243, Republic of Korea. |
| المصدر: | Biomolecules & therapeutics [Biomol Ther (Seoul)] 2024 Jul 01; Vol. 32 (4), pp. 499-507. Date of Electronic Publication: 2024 Jun 25. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Korean Society of Applied Pharmacology Country of Publication: Korea (South) NLM ID: 101472832 Publication Model: Print-Electronic Cited Medium: Print ISSN: 1976-9148 (Print) Linking ISSN: 19769148 NLM ISO Abbreviation: Biomol Ther (Seoul) Subsets: PubMed not MEDLINE |
| أسماء مطبوعة: | Original Publication: Seoul : Korean Society of Applied Pharmacology |
| مستخلص: | Specific sensitivity of the skin to ultraviolet B (UVB) rays is one of the mechanisms responsible for widespread skin damage. This study tested whether 1,3,5-trihydroxybenzene (THB), a compound abundant in marine products, might inhibit UVB radiation-induced NADPH oxidase 4 (NOX4) in both human HaCaT keratinocytes and mouse dorsal skin and explore its cytoprotective mechanism. The mechanism of action was determined using western blotting, immunocytochemistry, NADP + /NADPH assay, reactive oxygen species (ROS) detection, and cell viability assay. THB attenuated UVB-induced NOX4 expression both in vitro and in vivo , and suppressed UVB-induced ROS generation via NADP + production, resulting in increased cell viability with decreased apoptosis. THB also reduced the expression of UVB-induced phosphorylated AMP-activated protein kinase (AMPK) and phosphorylated c-Jun N-terminal kinase (JNK). THB suppressed UVB-induced NOX4 expression and ROS generation by inhibiting AMPK and JNK signaling pathways, thereby inhibiting cellular damage. These results showed that THB could be developed as a UV protectant. |
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| فهرسة مساهمة: | Keywords: 1,3,5-Trihydroxybenzene; AMP-activated protein kinase; NADPH oxidase; Ultraviolet B; c-Jun N-terminal kinase |
| تواريخ الأحداث: | Date Created: 20240624 Latest Revision: 20240703 |
| رمز التحديث: | 20240703 |
| مُعرف محوري في PubMed: | PMC11214967 |
| DOI: | 10.4062/biomolther.2024.054 |
| PMID: | 38914480 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1976-9148 |
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| DOI: | 10.4062/biomolther.2024.054 |