دورية أكاديمية
Intertwining roles of R-loops and G-quadruplexes in DNA repair, transcription and genome organization.
| العنوان: | Intertwining roles of R-loops and G-quadruplexes in DNA repair, transcription and genome organization. |
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| المؤلفون: | Wulfridge P; Gene Expression and Regulation Program, The Wistar Institute, Philadelphia, PA, USA.; Penn Epigenetics Institute, University of Pennsylvania, Philadelphia, PA, USA., Sarma K; Gene Expression and Regulation Program, The Wistar Institute, Philadelphia, PA, USA. kavitha@sarmalab.com.; Penn Epigenetics Institute, University of Pennsylvania, Philadelphia, PA, USA. kavitha@sarmalab.com. |
| المصدر: | Nature cell biology [Nat Cell Biol] 2024 Jul; Vol. 26 (7), pp. 1025-1036. Date of Electronic Publication: 2024 Jun 24. |
| نوع المنشور: | Journal Article; Review |
| اللغة: | English |
| بيانات الدورية: | Publisher: Macmillan Magazines Ltd Country of Publication: England NLM ID: 100890575 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-4679 (Electronic) Linking ISSN: 14657392 NLM ISO Abbreviation: Nat Cell Biol Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: London : Macmillan Magazines Ltd., [1999- |
| مواضيع طبية MeSH: | G-Quadruplexes* , DNA Repair* , R-Loop Structures*/genetics , Transcription, Genetic*, Humans ; Animals ; DNA/metabolism ; DNA/genetics ; DNA/chemistry ; Genome/genetics ; Gene Regulatory Networks ; RNA/metabolism ; RNA/genetics ; RNA/chemistry ; Neoplasms/genetics ; Neoplasms/pathology ; Neoplasms/metabolism |
| مستخلص: | R-loops are three-stranded nucleic acid structures that are abundant and widespread across the genome and that have important physiological roles in many nuclear processes. Their accumulation is observed in cancers and neurodegenerative disorders. Recent studies have implicated a function for R-loops and G-quadruplex (G4) structures, which can form on the displaced single strand of R-loops, in three-dimensional genome organization in both physiological and pathological contexts. Here we discuss the interconnected functions of DNA:RNA hybrids and G4s within R-loops, their impact on DNA repair and gene regulatory networks, and their emerging roles in genome organization during development and disease. (© 2024. Springer Nature Limited.) |
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| معلومات مُعتمدة: | R01NS127828 U.S. Department of Health & Human Services | National Institutes of Health (NIH); R01GM143229 U.S. Department of Health & Human Services | National Institutes of Health (NIH); F32GM143832 U.S. Department of Health & Human Services | National Institutes of Health (NIH) |
| المشرفين على المادة: | 9007-49-2 (DNA) 63231-63-0 (RNA) |
| تواريخ الأحداث: | Date Created: 20240624 Date Completed: 20240716 Latest Revision: 20240724 |
| رمز التحديث: | 20240726 |
| DOI: | 10.1038/s41556-024-01437-4 |
| PMID: | 38914786 |
| قاعدة البيانات: | MEDLINE |
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| DOI: | 10.1038/s41556-024-01437-4 |